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1Hypoxia-altitude simulation test to predict altitude-related adverse health effects in COPD patientspor Bauer, Meret, Müller, Julian, Schneider, Simon R., Buenzli, Simone, Furian, Michael, Ulrich, Tanja, Carta, Arcangelo F., Bader, Patrick R., Lichtblau, Mona, Taalaibekova, Ajian, Raimberdiev, Madiiar, Champigneulle, Benoit, Sooronbaev, Talant, Bloch, Konrad E., Ulrich, Silvia“…BACKGROUND/AIMS: Amongst numerous travellers to high altitude (HA) are many with the highly prevalent COPD, who are at particular risk for altitude-related adverse health effects (ARAHE). …”
Publicado 2023
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2por Schwarz, Esther I, Latshang, Tsogyal D, Furian, Michael, Flück, Deborah, Segitz, Sebastian, Müller-Mottet, Severine, Ulrich, Silvia, Bloch, Konrad E, Kohler, Malcolm“…MATERIALS AND METHODS: Continuous morning beat-to-beat BP was noninvasively measured with a Finometer(®) device for 10 minutes at low altitude (490 m, Zurich, Switzerland) and for 2 days at moderate altitude (2,590 m, Davos Jakobshorn, Switzerland) – the order of altitude exposure was randomized. …”
Publicado 2019
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3por Bloch, Konrad E., Sooronbaev, Talant M., Ulrich, Silvia, Lichtblau, Mona, Furian, Michael“…In addition, hypobaric hypoxia may impair postural control, psycho-motor, and cognitive performance in patients with COPD during altitude sojourns. Randomized, placebo-controlled trials have shown that preventive treatment with oxygen at night or with acetazolamide reduces the risk of ARAHE in patients with COPD while preventive dexamethasone treatment improves oxygenation and altitude-induced excessive sleep apnea, and lowers systemic and pulmonary artery pressure. …”
Publicado 2023
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4por Pun, Matiram, Guadagni, Veronica, Bettauer, Kaitlyn M., Drogos, Lauren L., Aitken, Julie, Hartmann, Sara E., Furian, Michael, Muralt, Lara, Lichtblau, Mona, Bader, Patrick R., Rawling, Jean M., Protzner, Andrea B., Ulrich, Silvia, Bloch, Konrad E., Giesbrecht, Barry, Poulin, Marc J.“…Objective: Neurocognitive functions are affected by high altitude, however the altitude effects of acclimatization and repeated exposures are unclear. …”
Publicado 2018
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5por Furian, Michael, Bitos, Konstantinos, Hartmann, Sara E., Muralt, Lara, Lichtblau, Mona, Bader, Patrick R., Rawling, Jean M., Ulrich, Silvia, Poulin, Marc J., Bloch, Konrad E.“…We hypothesized that prolonged and repeated high-altitude exposure will improve altitude-induced deoxygenation and breathing instability. …”
Publicado 2022
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6por Furian, Michael, Flueck, Deborah, Latshang, Tsogyal D, Scheiwiller, Philipp M, Segitz, Sebastian Daniel, Mueller-Mottet, Séverine, Murer, Christian, Steiner, Adrian, Ulrich, Silvia, Rothe, Thomas, Kohler, Malcolm, Bloch, Konrad E“…OBJECTIVE: To evaluate the effects of altitude travel on exercise performance and symptoms in lowlanders with COPD. …”
Publicado 2018
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7por Saxer, Stéphanie, Schneider, Simon R., Appenzeller, Paula, Bader, Patrick R., Lichtblau, Mona, Furian, Michael, Sheraliev, Ulan, Estebesova, Bermet, Emilov, Berik, Sooronbaev, Talant, Bloch, Konrad E., Ulrich, Silvia“…BACKGROUND: To investigate the effect of asthma rehabilitation at high altitude (3100 m, HA) compared to low altitude (760 m, LA). …”
Publicado 2019
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8por Pun, Matiram, Hartmann, Sara E., Furian, Michael, Dyck, Adrienna M., Muralt, Lara, Lichtblau, Mona, Bader, Patrick R., Rawling, Jean M., Ulrich, Silvia, Bloch, Konrad E., Poulin, Marc J.“…Aim: High altitude (HA) hypoxia may affect cognitive performance and sleep quality. …”
Publicado 2018
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9por Li, Taomei, Tan, Lu, Furian, Michael, Zhang, Yanyan, Luo, Lian, Lei, Fei, Xue, Xiaofang, He, Jiaming, Tang, Xiangdong“…Importance: To date, there is no established evidence of sex-specific differences in altitude-induced sleep-disordered breathing (SDB) during polysomnography-confirmed sleep. …”
Publicado 2022
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10por Lichtblau, Mona, Saxer, Stéphanie, Latshang, Tsogyal D., Aeschbacher, Sayaka S., Huber, Fabienne, Scheiwiller, Philipp M., Herzig, Joël J., Schneider, Simon R., Hasler, Elisabeth D., Furian, Michael, Bloch, Konrad E., Ulrich, Silvia“…Introduction: Stable patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension (PH) wish to undergo altitude sojourns or air travel but fear disease worsening. …”
Publicado 2020
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11Validation of a Portable Blood Gas Analyzer for Use in Challenging Field Conditions at High Altitudepor Nawrocki, Janek, Furian, Michael, Buergin, Aline, Mayer, Laura, Schneider, Simon, Mademilov, Maamed, Bloch, Madeleine S., Sooronbaev, Talant M., Ulrich, Silvia, Bloch, Konrad E.“…METHODS: In healthy individuals and patients with chronic obstructive pulmonary disease participating in clinical field studies at different altitudes, arterial blood samples were obtained at rest and during exercise in a hospital at 760 m and in a high altitude clinic at 3100 m. …”
Publicado 2021
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12por Schneider, Simon R., Lichtblau, Mona, Furian, Michael, Mayer, Laura C., Berlier, Charlotte, Müller, Julian, Saxer, Stéphanie, Schwarz, Esther I., Bloch, Konrad E., Ulrich, Silvia“…Prediction of adverse health effects at altitude or during air travel is relevant, particularly in pre-existing cardiopulmonary disease such as pulmonary arterial or chronic thromboembolic pulmonary hypertension (PAH/CTEPH, PH). …”
Publicado 2022
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13por Forrer, Aglaia, Gaisl, Thomas, Sevik, Ahmet, Meyer, Michelle, Senteler, Luzi, Lichtblau, Mona, Bloch, Konrad Ernst, Ulrich, Silvia, Furian, Michael“…IMPORTANCE: With increasing altitude, the partial pressure of inspired oxygen decreases and, consequently, the Pao(2) decreases. …”
Publicado 2023
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14“…Maximal values of aerobic power (VO(2)max) and peripheral oxygen saturation (SpO(2)max) decline in parallel with gain in altitude. Whereas this relationship has been well investigated when acutely exposed to high altitude, potential benefits of acclimatization on SpO(2) and related VO(2)max in healthy and diseased individuals have been much less considered. …”
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15por Reiser, Aurelia E., Furian, Michael, Lichtblau, Mona, Buergin, Aline, Schneider, Simon R., Appenzeller, Paula, Mayer, Laura, Muralt, Lara, Mademilov, Maamed, Abdyraeva, Ainura, Aidaralieva, Shoira, Muratbekova, Aibermet, Akylbekov, Azamat, Sheraliev, Ulan, Shabykeeva, Saltanat, Sooronbaev, Talant M., Ulrich, Silvia, Bloch, Konrad E.“…OBJECTIVE: Altitude travel is increasingly popular also for middle-aged and older tourists and professionals. …”
Publicado 2023
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16por Schneider, Simon R., Mayer, Laura C., Lichtblau, Mona, Berlier, Charlotte, Schwarz, Esther I., Saxer, Stéphanie, Tan, Lu, Furian, Michael, Bloch, Konrad E., Ulrich, Silvia“…For safety, patients with sustained hypoxaemia at altitude (peripheral oxygen saturation <80% for >30 min or <75% for >15 min) received oxygen therapy. …”
Publicado 2021
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17por Lichtblau, Mona, Saxer, Stéphanie, Mayer, Laura, Sheraliev, Ulan, Mademilov, Maamed, Furian, Michael, Buergin, Aline, Schweiwiller, Philipp M., Schneider, Simon R., Tanner, Felix C., Sooronbaev, Talant, Bloch, Konrad E., Ulrich, Silvia“…BACKGROUND: COPD may predispose to symptomatic pulmonary hypertension at high altitude. We investigated haemodynamic changes in lowlanders with COPD ascending to 3100 m and evaluated whether preventive acetazolamide treatment would attenuate the altitude-induced increase in pulmonary artery pressure (PAP). …”
Publicado 2023
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18por Champigneulle, Benoit, Reinhard, Lukas, Mademilov, Maamed, Marillier, Mathieu, Ulrich, Tanja, Carta, Arcangelo F., Scheiwiller, Philipp, Shabykeeva, Saltanat B., Sheraliev, Ulan U., Abdraeva, Ainura K., Magdieva, Kamila M., Mirzalieva, Gulzada, Taalaibekova, Aijan T., Ozonova, Aigul K., Erkinbaeva, Aidai O., Shakiev, Nurdin U., Azizbekov, Syimyk A., Ainslie, Philip N., Sooronbaev, Talant M., Ulrich, Silvia, Bloch, Konrad E., Verges, Samuel, Furian, Michael“…Concurrent measurements of cPaO(2) (AGM100) and mPaO(2) (EPOC, portable aBGA device) were performed in 131 moderate-to-severe COPD patients (mean ±SD FEV(1): 60 ± 10% of predicted value) and low-altitude residents, becoming hypoxemic (i.e., SpO(2) < 94%) during a short stay at 3100 m (Too-Ashu, Kyrgyzstan). …”
Publicado 2023
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19por Lichtblau, Mona, Latshang, Tsogyal D., Aeschbacher, Sayaka S., Huber, Fabienne, Scheiwiller, Philipp M., Ulrich, Stefanie, Schneider, Simon R., Hasler, Elisabeth D., Furian, Michael, Bloch, Konrad E., Saxer, Stéphanie, Ulrich, Silvia“…INTRODUCTION: We investigated whether nocturnal oxygen therapy (NOT) mitigates the increase of pulmonary artery pressure in patients during daytime with chronic obstructive pulmonary disease (COPD) traveling to altitude. METHODS: Patients with COPD living below 800 m underwent examinations at 490 m and during two sojourns at 2,048 m (with a washout period of 2 weeks < 800 m between altitude sojourns). …”
Publicado 2021
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20por Meszaros, Martina, Latshang, Tsogyal D, Aeschbacher, Sayaka S, Huber, Fabienne, Flueck, Deborah, Lichtblau, Mona, Ulrich, Stefanie, Hasler, Elisabeth D, Scheiwiller, Philipp M, Reinhard, Lukas, Ulrich, Silvia, Bloch, Konrad E, Furian, Michael, Schwarz, Esther I“…Hypoxemia is marked during sleep. In COPD, altitude exposure is associated with an increase in blood pressure (BP) and a decrease in baroreflex-sensitivity (BRS). …”
Publicado 2021
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