Mostrando 1 - 19 Resultados de 19 Para Buscar '"The Messengers"', tiempo de consulta: 1.55s Limitar resultados
  1. 1
    “…Analogues of the potent Ca(2+) releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. …”
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    ‘Click cyclic ADP-ribose’: a neutral second messenger mimic
  2. 2
    “…Cyclic ADP-ribose is an important Ca(2+)-mobilizing cytosolic messenger synthesized from β-NAD(+) by ADP-ribosyl cyclases (ARCs). …”
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    Ca(2+) Signaling Occurs via Second Messenger Release from Intraorganelle Synthesis Sites
  3. 3
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    The Calcium-mobilizing Messenger Nicotinic Acid Adenine Dinucleotide Phosphate Participates in Sperm Activation by Mediating the Acrosome Reaction
  4. 4
    “…Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR) are Ca(2+)-mobilizing messengers important for modulating cardiac excitation–contraction coupling and pathophysiology. …”
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    Synthesis of the Ca(2+)-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling
  5. 5
    “…Using permeabilized guinea pig detrusor and taenia caecum, we show that all three Ca(2+)-mobilizing messengers cause contractions in both types of smooth muscle. …”
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    TPC2 Proteins Mediate Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)- and Agonist-evoked Contractions of Smooth Muscle
  6. 6
    “…Gated by the second messengers, NAADP and PI(3,5)P(2), TPCs are an integral part of fundamental signal-transduction pathways, but their array and plasticity of cation conductances (Na(+), Ca(2+), H(+)) allow them to variously signal electrically, osmotically or chemically. …”
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    Two-pore channels: going with the flows
  7. 7
    “…The endoplasmic reticulum (ER) and acidic organelles (endo-lysosomes) act as separate Ca(2+) stores that release Ca(2+) in response to the second messengers IP(3) and cADPR (ER) or NAADP (acidic organelles). …”
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    Bidirectional Ca(2+) signaling occurs between the endoplasmic reticulum and acidic organelles
  8. 8
    “…Of the three major Ca(2+) mobilizing messengers described, the most potent, nicotinic acid adenine dinucleotide phosphate (NAADP) is the least well understood in terms of its molecular targets [1]. …”
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    Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca(2+) Signaling and Endolysosomal Trafficking
  9. 9
    “…Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5′-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational analysis investigated by (1)H NMR spectroscopy revealed that a C2′ endo/syn conformation of the “southern” ribose is crucial for agonist or antagonist activity at the SUH-, but not at the T cell-cADPR receptor.…”
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    Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn “southern” ribose conformation underlies activity at the sea urchin cADPR receptor
  10. 10
    por Davis, Lianne C., Galione, Antony
    Publicado 2013
    “…However, not all sources of Ca(2+) stimulate exocytosis: we have recently demonstrated that it is the cytolytic granules themselves that are the source of the Ca(2+) that most efficiently drives their own exocytosis; release of Ca(2+) from the granules is only activated by the Ca(2+)-mobilizing messenger NAADP (nicotinic acid adenine dinucleotide phosphate) that acts upon target two-pore channels (TPCs) present on the granules. …”
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    Cytolytic granules supply Ca(2+) for their own exocytosis via NAADP and resident two-pore channels
  11. 11
    “…Research into the biological role of the Ca(2+)-releasing second messenger NAADP (nicotinic acid adenine dinucleotide phosphate) has been hampered by a lack of chemical probes. …”
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    Identification of a chemical probe for NAADP by virtual screening
  12. 12
    “…Here, we reveal that endo‐lysosomes act as platforms for a new phagocytic signalling pathway in which FcγR activation recruits the second messenger NAADP and thereby promotes the opening of Ca(2+)‐permeable two‐pore channels (TPCs). …”
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    NAADP‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca(2+) nanodomains, calcineurin and dynamin
  13. 13
    “…The measurement of changes in nicotinic acid adenine dinucleotide phosphate (NAADP) levels in cells has been, and remains, key to the investigation of the functions of NAADP as a Ca(2+)-releasing second messenger. Here we provide details of how to isolate NAADP from cells by extraction with perchloric acid and then measure the NAADP using a radioreceptor assay. …”
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    Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate
  14. 14
    “…The second messenger NAADP triggers Ca(2+) release from endo-lysosomes. …”
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    Expression of Ca(2+)-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells
  15. 15
    “…Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) stimulates calcium release from acidic stores such as lysosomes and is a highly potent calcium-mobilising second messenger. NAADP plays an important role in calcium signalling in the heart under basal conditions and following β-adrenergic stress. …”
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    High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart
  16. 16
    “…Here we identify the Ca(2+)-mobilizing messenger nicotinic acid adenine dinucleotide phosphate (NAADP) and its recently identified molecular target, two-pore channels (TPCs) [5–7], as being important for T cell receptor signaling in CTLs. …”
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    NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing
  17. 17
    “…The priming effect could be mimicked by a direct application of nicotinic acid adenine dinucleotide phosphate, the endogenous messenger regulating TPCs, or a selective TPC2 agonist, TPC2-A1-N, or blocked by the antagonist Ned-19. …”
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    Endolysosomal TPCs regulate social behavior by controlling oxytocin secretion
  18. 18
    “…Nicotinic acid adenine dinucleotide phosphate (NAADP) is a messenger that regulates calcium release from intracellular acidic stores. …”
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    Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg
  19. 19
    “…Here we show using total internal reflection fluorescence (TIRF) microscopy that glucose as well as the Ca(2+) mobilising messenger nicotinic acid adenine dinucleotide phosphate (NAADP), known to operate in β-cells, lead to highly localised elementary intracellular Ca(2+) signals. …”
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    Glucose and NAADP trigger elementary intracellular β-cell Ca(2+) signals
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