“…Here we demonstrate that c-di-GMP also intervenes later in development to control differentiation of the reproductive hyphae into spores by arming a novel anti-σ (RsiG) to bind and sequester a sporulation-specific σ factor (σ(WhiG)). We present the structure of the RsiG-(c-di-GMP)(2)-σ(WhiG) complex, revealing an unusual, partially intercalated c-di-GMP dimer bound at the RsiG-σ(WhiG) interface. …”
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“…We recently showed c-di-GMP controls this transition by arming a unique anti-σ, RsiG, to bind the sporulation-specific σ, WhiG. The Streptomyces venezuelae RsiG–(c-di-GMP)(2)–WhiG structure revealed that a monomeric RsiG binds c-di-GMP via two E(X)(3)S(X)(2)R(X)(3)Q(X)(3)D repeat motifs, one on each helix of an antiparallel coiled-coil. …”
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