“…The model predicted the emergence of a delayed phase shift between the pulsing activity of the different sporulation genes, as well as the existence of a stable state, with elevated Spo0A activity but no sporulation, embedded within the dynamical structure of the system. To test the model, we used time-lapse fluorescence microscopy to measure dynamics of single cells initiating sporulation. …”
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“…Multiple Sclerosis (MS) is an autoimmune disease driving inflammatory and degenerative processes that damage the central nervous system (CNS). However, it is not well understood how these events interact and evolve to evoke such a highly dynamic and heterogeneous disease. …”
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“…Pairwise analysis revealed that two sigma factors rarely pulse simultaneously and that some pairs are anti-correlated, indicating that RNAP utilization alternates among different sigma factors. Mathematical modeling revealed how stochastic time-sharing dynamics can emerge from pulse-generating sigma factor regulatory circuits actively competing for RNAP. …”
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“…Together, these results provide a framework for analysis of more complex Notch-dependent developmental systems.…”
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“…How cells reconcile these seemingly contradictory requirements through the dynamics of cellular decision-making is poorly understood. …”
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“…By controlling both cis- and trans-Delta levels, and monitoring the dynamics of a Notch reporter, we measured the combined cis-trans input-output relationship for the Notch-Delta system. …”
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