-
1por Blum, Kenneth, Oscar-Berman, Marlene, Demetrovics, Zsolt, Barh, Debmalya, Gold, Mark S.“…Interestingly, albeit others, in one published study, we were able to describe lifetime RDS behaviors in a recovering addict (17 years sober) blindly by assessing resultant Genetic Addiction Risk Score (GARS™) data only. We hypothesize that genetic testing at an early age may be an effective preventive strategy to reduce or eliminate pathological substance and behavioral seeking activity. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
2por Blum, Kenneth, Kazmi, Shan, Modestino, Edward J., Downs, Bill William, Bagchi, Debasis, Baron, David, McLaughlin, Thomas, Green, Richard, Jalali, Rehan, Thanos, Panayotis K., Elman, Igor, Badgaiyan, Rajendra D., Bowirrat, Abdalla, Gold, Mark S.“…The formulations are based on the results of the addiction risk severity (GARS) test. Based on both neurogenetic and epigenetic evidence, the test evaluates the presence of reward genes and risk alleles. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3por Blum, Kenneth, Simpatico, Thomas, Badgaiyan, Rajendra D., Demetrovics, Zsolt, Fratantonio, James, Agan, Gozde, Febo, Marcelo, Gold, Mark S.“…We propose a Reward Deficiency System Solution that promotes early identification and stratification of risk alleles by utilizing GARS(Dx), allowing for customized nutrigenomic targeting of these risk alleles by altering KB220Z ingredients as an algorithmic function of carrying these polymorphic DNA–SNPS, potentially yielding the first ever nutrigenomic solution for addiction and pain.…”
Publicado 2015
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4por Moran, Mark, Blum, Kenneth, Ponce, Jessica Valdez, Lott, Lisa, Gondré–Lewis, Marjorie C., Badgaiyan, Sampada, Brewer, Raymond, Downs, B. William, Fynman, Philip, Weingarten, Alexander, Cadet, Jean Lud, Smith, David E., Baron, David, Thanos, Panayotis K., Modestino, Edward J., Badgaiyan, Rajendra D., Elman, Igor, Gold, Mark S.“…Evaluation of pain clinic patients with the Genetic Addiction Risk Score (GARS) test and the Addiction Severity Index (ASI- Media Version V) revealed that GARS scores equal to or greater than 4 and 7 alleles significantly predicted drug and alcohol severity, respectively. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5por Modestino, Edward Justin, Blum, Kenneth, Dennen, Catherine A., Downs, B. William, Bagchi, Debasis, Llanos-Gomez, Luis, Elman, Igor, Baron, David, Thanos, Panayotis K., Badgaiyan, Rajendra D., Braverman, Eric R., Gupta, Ashim, Gold, Mark S., Bowirrat, AbdallaEnlace del recurso
Publicado 2022
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
6por Blum, Kenneth, Han, David, Gupta, Ashim, Baron, David, Braverman, Eric R., Dennen, Catherine A., Kazmi, Shan, Llanos-Gomez, Luis, Badgaiyan, Rajendra D., Elman, Igor, Thanos, Panayotis K., Downs, Bill W., Bagchi, Debasis, Gondre-Lewis, Marjorie C., Gold, Mark S., Bowirrat, Abdalla“…While most of the research related to GARS is derived from our laboratory, we are encouraging more independent research to confirm our findings.…”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
7por Gupta, Ashim, Bowirrat, Abdalla, Gomez, Luis Llanos, Baron, David, Elman, Igor, Giordano, John, Jalali, Rehan, Badgaiyan, Rajendra D., Modestino, Edward J., Gold, Mark S., Braverman, Eric R., Bajaj, Anish, Blum, Kenneth“…The GARS test results identify high-risk for both drug and alcohol, and H-Wave can be initiated to treat pain instead of opioids. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
8por Blum, Kenneth, Brodie, Mark S., Pandey, Subhash C., Cadet, Jean Lud, Gupta, Ashim, Elman, Igor, Thanos, Panayotis K., Gondre-Lewis, Marjorie C., Baron, David, Kazmi, Shan, Bowirrat, Abdalla, Febo, Marcelo, Badgaiyan, Rajendra D., Braverman, Eric R., Dennen, Catherine A., Gold, Mark S.“…We present a hypothesis that identification of KCNK13 and RASGRF2 genes’ risk polymorphism, coupled with genetic addiction risk score (GARS)-guided precision pro-dopamine regulation, will mitigate binge alcohol drinking. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
9por Ceccanti, Mauro, Blum, Kenneth, Bowirrat, Abdalla, Dennen, Catherine A., Braverman, Eric R., Baron, David, Mclaughlin, Thomas, Giordano, John, Gupta, Ashim, Downs, Bernard W., Bagchi, Debasis, Barh, Debmalya, Elman, Igor, Thanos, Panayotis K., Badgaiyan, Rajendra D., Edwards, Drew, Gold, Mark S.“…Therefore, based on this extensive literature and additional research, this team of coauthors suggests that, in the future, in addition to the current nonpharmacological therapies, patients with opioid-induced NAS should undergo genetic assessment (i.e., the genetic addiction risk severity (GARS) test), which can subsequently be used to guide DNA-directed precision amino-acid enkephalinase inhibition (KB220) therapy as a frontline modality instead of potent opioids.…”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
10por Dennen, Catherine A., Blum, Kenneth, Bowirrat, Abdalla, Thanos, Panayotis K., Elman, Igor, Ceccanti, Mauro, Badgaiyan, Rajendra D., McLaughlin, Thomas, Gupta, Ashim, Bajaj, Anish, Baron, David, Downs, B. William, Bagchi, Debasis, Gold, Mark S.“…This case series presents the novel genetic addiction risk score (GARS), which shows a high prevalence of polymorphic risk alleles of reward genes in a nuclear family with multiple reward deficiency syndrome (RDS) behavioral issues expressing a hypodopaminergic antecedent. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
11por Blum, Kenneth, Han, David, Bowirrat, Abdalla, Downs, Bernard William, Bagchi, Debasis, Thanos, Panayotis K., Baron, David, Braverman, Eric R., Dennen, Catherine A., Gupta, Ashim, Elman, Igor, Badgaiyan, Rajendra D., Llanos-Gomez, Luis, Khalsa, Jag, Barh, Debmalya, McLaughlin, Thomas, Gold, Mark S.“…To develop an accurate test to help identify those at risk for at least alcohol use disorder (AUD), a subset of reward deficiency syndrome (RDS), Blum’s group developed the genetic addiction risk severity (GARS) test, consisting of ten genes and eleven associated risk alleles. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
12por Blum, Kenneth, Badgaiyan, Rajendra D., Agan, Gozde, Fratantonio, James, Simpatico, Thomas, Febo, Marcelo, Haberstick, Brett C., Smolen, Andrew, Gold, Mark S.“…CONCLUSION: Albeit our bias, this Clinical Pearl discusses the facts and fictions behind molecular genetic testing in RDS and the significance behind the development of the Genetic Addiction Risk Score (GARS(PREDX)™), the first test to accurately predict one’s genetic risk for RDS.…”
Publicado 2015
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
13Reward Deficiency Syndrome (RDS): A Cytoarchitectural Common Neurobiological Trait of All Addictionspor Blum, Kenneth, Bowirrat, Abdalla, Braverman, Eric R., Baron, David, Cadet, Jean Lud, Kazmi, Shan, Elman, Igor, Thanos, Panyotis K., Badgaiyan, Rajendra D., Downs, William B., Bagchi, Debasis, Llanos-Gomez, Luis, Gold, Mark S.“…Taking a Genetic Addiction Risk Severity (GARS) test combined with a the KB220Z semi-customized nutrigenomic supplement effectively restores dopamine homeostasis (WC 199).…”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
14por Blum, Kenneth, Dennen, Catherine A., Elman, Igor, Bowirrat, Abdalla, Thanos, Panayotis K., Badgaiyan, Rajendra D., Downs, B. William, Bagchi, Debasis, Baron, David, Braverman, Eric R., Gupta, Ashim, Green, Richard, McLaughlin, Thomas, Barh, Debmalya, Gold, Mark S.“…Epigenetic repair of hypodopaminergia, the causative basis of addictive behaviors, may involve precision DNA-guided therapy achieved by combining the Genetic Addiction Risk Severity (GARS) test with a researched neutraceutical having a number of variant names, including KB220Z. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto