Mostrando 1 - 17 Resultados de 17 Para Buscar '"The Messengers"', tiempo de consulta: 0.29s Limitar resultados
  1. 1
    “…Receptor-mediated formation, metabolism, and mode of action of these novel second messengers in T-lymphocytes will be reviewed.…”
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    Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling
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    Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR)
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    por Guse, Andreas H.
    Publicado 2023
    “…Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated cousin NADP are precursors for the enzymatic formation of the Ca(2+)-mobilizing second messengers adenosine diphosphoribose (ADPR), 2′-deoxy-ADPR, cyclic ADPR, and nicotinic acid adenine dinucleotide phosphate (NAADP). …”
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    Enzymology of Ca(2+)-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases
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    por Guse, Andreas H.
    Publicado 2020
    “…Ca(2+)-mobilizing adenine nucleotide second messengers cyclic adenosine diphosphoribose, (cADPR), nicotinic acid adenine dinucleotide phosphate (NAADP), adenosine diphosphoribose (ADPR), and 2′deoxy-ADPR were discovered since the late 1980s. …”
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    25 Years of Collaboration with A Genius: Deciphering Adenine Nucleotide Ca(2+) Mobilizing Second Messengers Together with Professor Barry Potter
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    “…Adenine nucleotide (AN) 2nd messengers, such as 3′,5′-cyclic adenosine monophosphate (cAMP), are central elements of intracellular signaling, but many details of their underlying processes remain elusive. …”
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    Membrane-Permeable Octanoyloxybenzyl-Masked cNMPs As Novel Tools for Non-Invasive Cell Assays
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    “…T cell activation starts with formation of second messengers that release Ca(2+) from the endoplasmic reticulum (ER) and thereby activate store-operated Ca(2+) entry (SOCE), one of the essential signals for T cell activation. …”
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    2-Methoxyestradiol and its derivatives inhibit store-operated Ca(2+) entry in T cells: Identification of a new and potent inhibitor
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    “…Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-releasing second messenger known to date, but the precise NAADP/Ca(2+) signalling mechanisms are still controversial. …”
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    Small Molecule Antagonists of NAADP-Induced Ca(2+) Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease
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    “…Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5′-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational analysis investigated by (1)H NMR spectroscopy revealed that a C2′ endo/syn conformation of the “southern” ribose is crucial for agonist or antagonist activity at the SUH-, but not at the T cell-cADPR receptor.…”
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    Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn “southern” ribose conformation underlies activity at the sea urchin cADPR receptor
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    por Wolf, Insa M. A., Guse, Andreas H.
    Publicado 2017
    “…Apparently, the second messenger nicotinic acid adenine dinucleotide phosphate is the first second messenger involved in initiation of Ca(2+) microdomains. …”
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    Ca(2+) Microdomains in T-Lymphocytes
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    “…Among these enzymes, CD38 can be seen under two perspectives: as the enzyme synthesizing Ca(2+)-mobilizing second messenger, starting from NAD(+), and as the major NAD(+)-consumer, to be inhibited to increase NAD(+) levels. …”
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    Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?
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    por Guse, Andreas H.
    Publicado 2022
    “…Nicotinic acid adenine dinucleotide phosphate (NAADP) is a universal Ca(2+) mobilizing second messenger essential for initiation of Ca(2+) signaling. …”
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    NAADP Signaling: New Kids on the Block
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    “…Over the years it has been controversially discussed whether the Ca(2+) mobilizing second messenger cyclic ADP ribose (cADPR) might also directly activate Ca(2+) entry via TRPM2. …”
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    Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?
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    “…Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that evokes calcium release from intracellular organelles by the engagement of calcium release channels, including members of the Transient Receptor Potential (TRP) family, such as TRPML1, the (structurally) related Two Pore Channel type 1 (TPC1) and TPC2 channels as well as Ryanodine Receptors type 1 (RYR1; Guse, 2012). …”
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    Contribution of NAADP to Glutamate-Evoked Changes in Ca(2+) Homeostasis in Mouse Hippocampal Neurons
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    “…Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-releasing second messenger known to date. Here, we report a new role for NAADP in arrhythmogenic Ca(2+) release in cardiac myocytes evoked by β-adrenergic stimulation. …”
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    Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation
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    “…cADPR is a second messenger that releases Ca(2+) from intracellular stores via the ryanodine receptor. …”
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    cADPR Does Not Activate TRPM2
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    “…Nicotinic acid adenine dinucleotide phosphate represents a newly identified second messenger in T cells involved in antigen receptor-mediated calcium signalling. …”
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    Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system
  17. 17
    “…We measured levels of Il22bp messenger RNA in colon tissues from wild-type, Tnf(–/–), Lta(–/–), and Ltb(–/–) mice. …”
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    IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans
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