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1por Romano, Camila Malta, de Carvalho-Mello, Isabel M. V. Guedes, Jamal, Leda F., de Melo, Fernando Lucas, Iamarino, Atila, Motoki, Marco, Pinho, João Renato Rebello, Holmes, Edward C., Zanotto, Paolo Marinho de Andrade“…Hepatitis C virus (HCV) infects 170 million people worldwide, and is a major public health problem in Brazil, where over 1% of the population may be infected and where multiple viral genotypes co-circulate. …”
Publicado 2010
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2por Wagner, Caroline E., Saad-Roy, Chadi M., Morris, Sinead E., Baker, Rachel E., Mina, Michael J., Farrar, Jeremy, Holmes, Edward C., Pybus, Oliver G., Graham, Andrea L., Emanuel, Ezekiel J., Levin, Simon A., Metcalf, C. Jessica E., Grenfell, Bryan T.Enlace del recurso
Publicado 2021
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3“…Under both scenarios, population bottlenecks at inter-host transmission act as a major barrier to host adaptation, greatly limiting the number of adaptive mutations that are able to cross the species barrier. …”
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4por Nelson, Martha I., Lemey, Philippe, Tan, Yi, Vincent, Amy, Lam, Tommy Tsan-Yuk, Detmer, Susan, Viboud, Cécile, Suchard, Marc A., Rambaut, Andrew, Holmes, Edward C., Gramer, MarieEnlace del recurso
Publicado 2011
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5por Geoghegan, Jemma L., Ren, Xiaoyun, Storey, Matthew, Hadfield, James, Jelley, Lauren, Jefferies, Sarah, Sherwood, Jill, Paine, Shevaun, Huang, Sue, Douglas, Jordan, Mendes, Fábio K., Sporle, Andrew, Baker, Michael G., Murdoch, David R., French, Nigel, Simpson, Colin R., Welch, David, Drummond, Alexei J., Holmes, Edward C., Duchêne, Sebastián, de Ligt, JoepEnlace del recurso
Publicado 2020
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6por Rogers, Matthew B., Song, Timothy, Sebra, Robert, Greenbaum, Benjamin D., Hamelin, Marie-Eve, Fitch, Adam, Twaddle, Alan, Cui, Lijia, Holmes, Edward C., Boivin, Guy, Ghedin, Elodie“…In this unique natural experiment, we were able to document the complex dynamics underlying the evolution of antiviral resistance. …”
Publicado 2015
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7por Romano, Camila M., de Melo, Fernando L., Corsini, Marco Aurelio B., Holmes, Edward C., Zanotto, Paolo M. de A.“…By excluding those ERV-K sequences generated by chromosomal duplication, we used 63 of the 106 elements to compare the population dynamics of ERV-K among species. This analysis indicated that both HERV-K and RhERV-K had similar demographic histories, including markedly smaller effective population sizes, compared to CERV-K. …”
Publicado 2007
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8por Dalziel, Benjamin D., Huang, Kai, Geoghegan, Jemma L., Arinaminpathy, Nimalan, Dubovi, Edward J., Grenfell, Bryan T., Ellner, Stephen P., Holmes, Edward C., Parrish, Colin R.“…Corresponding phylogenetic analyses show strong geographic clustering in three US regions, and that the effective reproductive number of the virus (R(e)) in the general dog population is close to 1.0. Our results highlight the critical role of host contact structure in CIV dynamics, and show how host contact networks could shape the evolution of pathogen transmission efficiency. …”
Publicado 2014
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9por Bourhy, Hervé, Nakouné, Emmanuel, Hall, Matthew, Nouvellet, Pierre, Lepelletier, Anthony, Talbi, Chiraz, Watier, Laurence, Holmes, Edward C., Cauchemez, Simon, Lemey, Philippe, Donnelly, Christl A., Rambaut, Andrew“…The development of novel approaches that combine epidemiological and genomic data provides new opportunities to reveal the spatiotemporal dynamics of infectious diseases and determine the processes responsible for their spread and maintenance. …”
Publicado 2016
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10por Rabaa, Maia A., Ty Hang, Vu Thi, Wills, Bridget, Farrar, Jeremy, Simmons, Cameron P., Holmes, Edward C.“…However, the processes that shape DENV transmission patterns at the scale of local populations are not well understood, particularly the impact of such factors as human population movement and urbanization. …”
Publicado 2010
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11por Saad-Roy, Chadi M., Morris, Sinead E., Metcalf, C. Jessica E., Mina, Michael J., Baker, Rachel E., Farrar, Jeremy, Holmes, Edward C., Pybus, Oliver G., Graham, Andrea L., Levin, Simon A., Grenfell, Bryan T., Wagner, Caroline E.“…Given vaccine dose shortages and logistical challenges, various deployment strategies are being proposed to increase population immunity levels to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). …”
Publicado 2021
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12por Geoghegan, Jemma L., Saavedra, Aldo F., Duchêne, Sebastián, Sullivan, Sheena, Barr, Ian, Holmes, Edward C.“…Although recent work suggests that influenza epidemics in the United States exhibit a strong geographical correlation, the spatiotemporal dynamics of influenza in Australia, a country and continent of approximately similar size and climate complexity but with a far smaller population, are not known. …”
Publicado 2018
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13por Nelson, Martha I., Lloyd-Smith, James O., Simonsen, Lone, Rambaut, Andrew, Holmes, Edward C., Chowell, Gerardo, Miller, Mark A., Spiro, David J., Grenfell, Bryan, Viboud, Cécile“…The Multinational Influenza Seasonal Mortality Study (MISMS) has strengthened global capacity to study the epidemiology and evolutionary dynamics of influenza viruses in 80 countries by organizing international research activities and training workshops. …”
Publicado 2019
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14por Eden, John-Sebastian, Chisholm, Rebecca H., Bull, Rowena A., White, Peter A., Holmes, Edward C., Tanaka, Mark M.“…Here, we develop a mathematical model that combines epidemiological dynamics with within-host evolution to quantify the relative contribution of immunocompromised hosts to the overall rate of pathogen evolution. …”
Publicado 2017
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15por Raghwani, Jayna, Rambaut, Andrew, Holmes, Edward C., Hang, Vu Ty, Hien, Tran Tinh, Farrar, Jeremy, Wills, Bridget, Lennon, Niall J., Birren, Bruce W., Henn, Matthew R., Simmons, Cameron P.“…We also observed an important relationship between the density of the human host population and the dispersion rate of dengue, such that DENV-1 tends to move from urban to rural populations, and that densely populated regions within Ho Chi Minh City act as major transmission foci. …”
Publicado 2011
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16“…Models of host-microbe dynamics typically assume a single-host population infected by a single pathogen. …”
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17por Talbi, Chiraz, Lemey, Philippe, Suchard, Marc A., Abdelatif, Elbia, Elharrak, Mehdi, Jalal, Nourlil, Faouzi, Abdellah, Echevarría, Juan E., Vazquez Morón, Sonia, Rambaut, Andrew, Campiz, Nicholas, Tatem, Andrew J., Holmes, Edward C., Bourhy, Hervé“…We used newly developed Bayesian phylogeographic methods to unravel the dynamics and determinants of the spread of dog rabies virus (RABV) in North Africa. …”
Publicado 2010
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18por Tan, Le Van, Tuyen, Nguyen Thi Kim, Thanh, Tran Tan, Ngan, Tran Thuy, Van, Hoang Minh Tu, Sabanathan, Saraswathy, Van, Tran Thi My, Thanh, Le Thi My, Nguyet, Lam Anh, Geoghegan, Jemma L., Ong, Kien Chai, Perera, David, Hang, Vu Thi Ty, Ny, Nguyen Thi Han, Anh, Nguyen To, Ha, Do Quang, Qui, Phan Tu, Viet, Do Chau, Tuan, Ha Manh, Wong, Kum Thong, Holmes, Edward C., Chau, Nguyen Van Vinh, Thwaites, Guy, van Doorn, H. Rogier“…Understanding EV-A71 population dynamics is therefore essential for understanding this emerging infection, and may provide pivotal information for vaccine development. …”
Publicado 2015
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19por Murcia, Pablo R., Hughes, Joseph, Battista, Patrizia, Lloyd, Lucy, Baillie, Gregory J., Ramirez-Gonzalez, Ricardo H., Ormond, Doug, Oliver, Karen, Elton, Debra, Mumford, Jennifer A., Caccamo, Mario, Kellam, Paul, Grenfell, Bryan T., Holmes, Edward C., Wood, James L. N.“…Hence, the mutational spectrum of intra-host EA-SIV populations is highly dynamic and allele fixation can occur with extreme rapidity. …”
Publicado 2012
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20por Kerr, Peter J., Liu, June, Cattadori, Isabella, Ghedin, Elodie, Read, Andrew F., Holmes, Edward C.“…This evolution of the virus was accompanied by selection for genetic resistance in the wild rabbit population, which may have created an ongoing co-evolutionary dynamic between resistance and virulence for efficient transmission. …”
Publicado 2015
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