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1por Özsoy, Ergi D, Yılmaz, Murat, Patlar, Bahar, Emecen, Güzin, Durmaz, Esra, Magwire, Michael M, Zhou, Shanshan, Huang, Wen, Anholt, Robert R H, Mackay, Trudy F C“…Here, we use the Drosophila melanogaster Genetic Reference Panel of sequenced inbred lines to evaluate the magnitude of naturally occurring epistasis modifying the effects of mutations in jing and inv, two transcription factors that have subtle quantitative effects on head morphology as homozygotes. …”
Publicado 2021
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2por Dembeck, Lauren M., Huang, Wen, Magwire, Michael M., Lawrence, Faye, Lyman, Richard F., Mackay, Trudy F. C.“…The amount of pigmentation on the abdomen of Drosophila melanogaster is a relatively simple morphological trait, which serves as a model for mapping the genetic basis of variation in complex phenotypes. …”
Publicado 2015
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3por Garlapow, Megan E., Huang, Wen, Yarboro, Michael T., Peterson, Kara R., Mackay, Trudy F. C.“…To gain insights in evolutionarily conserved genetic principles that regulate food intake, we took advantage of a model system, Drosophila melanogaster, in which food intake, environmental conditions and genetic background can be controlled precisely. …”
Publicado 2015
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4por Carnes, Megan Ulmer, Campbell, Terry, Huang, Wen, Butler, Daniel G., Carbone, Mary Anna, Duncan, Laura H., Harbajan, Sasha V., King, Edward M., Peterson, Kara R., Weitzel, Alexander, Zhou, Shanshan, Mackay, Trudy F. C.“…Here, we assessed the genetic divergence between five Drosophila melanogaster lines selected for postponed senescence for over 170 generations (O lines) and five lines from the same base population maintained at a two week generation interval for over 850 generations (B lines). …”
Publicado 2015
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5por Arya, Gunjan H., Magwire, Michael M., Huang, Wen, Serrano-Negron, Yazmin L., Mackay, Trudy F.C., Anholt, Robert R.H.“…To explore the genetic basis of variation in olfactory perception, we measured behavioral responses to 14 chemically diverse naturally occurring odorants in 260400 flies from 186 lines of the Drosophila melanogaster Genetic Reference Panel, a population of inbred wild-derived lines with sequenced genomes. …”
Publicado 2015
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6por Huang, Wen, Carbone, Mary Anna, Lyman, Richard F., Anholt, Robert R. H., Mackay, Trudy F. C.“…Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). …”
Publicado 2020
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7“…Here, we exploit natural variation in the inbred, sequenced lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) to map genetic variants affecting recombination rate. …”
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9por Parker, Grace A., Kohn, Nathan, Spirina, Ally, McMillen, Anna, Huang, Wen, Mackay, Trudy F. C.“…Here, we analyzed the pattern of genetic divergence between long-lived (O) Drosophila melanogaster lines selected for postponed reproductive senescence and unselected control (B) lines. …”
Publicado 2020
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10por Yanagawa, Aya, Huang, Wen, Yamamoto, Akihiko, Wada-Katsumata, Ayako, Schal, Coby, Mackay, Trudy F. C.“…We quantified spontaneous grooming behavior in 201 sequenced lines of the Drosophila melanogaster Genetic Reference Panel and observed significant genetic variation in spontaneous grooming, with broad-sense heritabilities of 0.25 and 0.24 in females and males, respectively. …”
Publicado 2020
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11por Dembeck, Lauren M, Böröczky, Katalin, Huang, Wen, Schal, Coby, Anholt, Robert R H, Mackay, Trudy F C“…Insect cuticular hydrocarbons (CHCs) prevent desiccation and serve as chemical signals that mediate social interactions. Drosophila melanogaster CHCs have been studied extensively, but the genetic basis for individual variation in CHC composition is largely unknown. …”
Publicado 2015
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12por Baker, Brandon M., Carbone, Mary Anna, Huang, Wen, Anholt, Robert R. H., Mackay, Trudy F. C.“…We used Drosophila melanogaster to map the genetic basis of naturally occurring variation in voluntary consumption of cocaine and methamphetamine. …”
Publicado 2021
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13por Lyman, Richard F., Lyman, Rachel A., Yamamoto, Akihiko, Huang, Wen, Harbison, Susan T., Zhou, Shanshan, Anholt, Robert R. H., Mackay, Trudy F. C.Enlace del recurso
Publicado 2023
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14por Huang, Wen, Massouras, Andreas, Inoue, Yutaka, Peiffer, Jason, Ràmia, Miquel, Tarone, Aaron M., Turlapati, Lavanya, Zichner, Thomas, Zhu, Dianhui, Lyman, Richard F., Magwire, Michael M., Blankenburg, Kerstin, Carbone, Mary Anna, Chang, Kyle, Ellis, Lisa L., Fernandez, Sonia, Han, Yi, Highnam, Gareth, Hjelmen, Carl E., Jack, John R., Javaid, Mehwish, Jayaseelan, Joy, Kalra, Divya, Lee, Sandy, Lewis, Lora, Munidasa, Mala, Ongeri, Fiona, Patel, Shohba, Perales, Lora, Perez, Agapito, Pu, LingLing, Rollmann, Stephanie M., Ruth, Robert, Saada, Nehad, Warner, Crystal, Williams, Aneisa, Wu, Yuan-Qing, Yamamoto, Akihiko, Zhang, Yiqing, Zhu, Yiming, Anholt, Robert R.H., Korbel, Jan O., Mittelman, David, Muzny, Donna M., Gibbs, Richard A., Barbadilla, Antonio, Johnston, J. Spencer, Stone, Eric A., Richards, Stephen, Deplancke, Bart, Mackay, Trudy F.C.“…The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic variation on molecular and organismal phenotypes. …”
Publicado 2014
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15por Ellis, Lisa L., Huang, Wen, Quinn, Andrew M., Ahuja, Astha, Alfrejd, Ben, Gomez, Francisco E., Hjelmen, Carl E., Moore, Kristi L., Mackay, Trudy F. C., Johnston, J. Spencer, Tarone, Aaron M.“…We determined female genome sizes using flow cytometry for 211 Drosophila melanogaster sequenced inbred strains from the Drosophila Genetic Reference Panel, and found significant conspecific and intrapopulation variation in genome size. …”
Publicado 2014
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16por Gabrawy, Mariann M., Khosravian, Nick, Morcos, George S., Morozova, Tatiana V., Jezek, Meagan, Walston, Jeremy D., Huang, Wen, Abadir, Peter M., Leips, Jeff“…Here, using 126 genetically distinct lines of Drosophila melanogaster, we tested the effects of Lisinopril on age-specific climbing speed and endurance. …”
Publicado 2022
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17por Huang, Wen, Campbell, Terry, Carbone, Mary Anna, Jones, W. Elizabeth, Unselt, Desiree, Anholt, Robert R. H., Mackay, Trudy F. C.“…Here, we quantified variation in life span in males and females reared in 3 thermal environments for the sequenced, inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) and an advanced intercross outbred population derived from a subset of DGRP lines. …”
Publicado 2020
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18por Montgomery, Sara L., Vorojeikina, Daria, Huang, Wen, Mackay, Trudy F. C., Anholt, Robert R. H., Rand, Matthew D.“…To examine how genetic variation impacts MeHg tolerance, we assessed developmental tolerance to MeHg using the sequenced, inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP). We found significant genetic variation in the effects of MeHg on development, measured by eclosion rate, giving a broad sense heritability of 0.86. …”
Publicado 2014
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19por Morgante, Fabio, Huang, Wen, Sørensen, Peter, Maltecca, Christian, Mackay, Trudy F. C.“…Here, we used data on whole genome sequences, deep RNA sequencing, and high quality phenotypes for three quantitative traits in the ∼200 inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) to compare the prediction accuracies of gene expression and genotypes for three complex traits. …”
Publicado 2020
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20por Morozova, Tatiana V., Huang, Wen, Pray, Victoria A., Whitham, Thomas, Anholt, Robert R. H., Mackay, Trudy F. C.“…BACKGROUND: Alcohol abuse and alcoholism are significant public health problems, but the genetic basis for individual variation in alcohol sensitivity remains poorly understood. Drosophila melanogaster presents a powerful model system for dissecting the genetic underpinnings that determine individual variation in alcohol-related phenotypes. …”
Publicado 2015
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