Mostrando 1 - 20 Resultados de 53 Para Buscar '"Leishmaniasis"', tiempo de consulta: 0.28s Limitar resultados
  1. 1
    por Kamhawi, Shaden
    Publicado 2017
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    The yin and yang of leishmaniasis control
  2. 2
    “…In Latin America, zoonotic visceral leishmaniasis (ZVL) arising from infection by L. infantum is primarily transmitted by Lutzomyia longipalpis sand flies. …”
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    Biomarkers for Zoonotic Visceral Leishmaniasis in Latin America
  3. 3
    “…Yet very little is known about the molecular characteristics of salivary proteins from different sandflies, particularly from vectors transmitting visceral leishmaniasis, the fatal form of the disease. Further knowledge of the repertoire of these salivary proteins will give us insights into the molecular evolution of these proteins and will help us select relevant antigens for the development of a vector based anti-Leishmania vaccine. …”
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    Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis
  4. 4
    “…BACKGROUND: Over the last 15 years, visceral leishmaniasis (VL) has emerged as a public health concern in Tbilisi, the capital of Georgia. …”
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    Epidemiologic Aspects of an Emerging Focus of Visceral Leishmaniasis in Tbilisi, Georgia
  5. 5
    “…Historically the western sahelian dry regions of Mali are known to be highly endemic for cutaneous leishmaniasis (CL) caused by Leishmania major, while cases are rarely reported from the Southern savanna forest of the country. …”
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    Prevalence of Cutaneous Leishmaniasis in Districts of High and Low Endemicity in Mali
  6. 6
    “…Here, we determined the outcome of a chronic infection with Trypanosoma brucei brucei on cutaneous leishmaniasis (CL) caused by L. major. C57BL/6 mice infected with T. b. brucei were given a sub-curative treatment with diminazene aceturate then coinfected with L. major by vector bites. …”
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    Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis
  7. 7
    “…Transmission modelling is required to identify the vectors that are a public health priority, the ones that must be controlled as part of the integrated control of leishmaniasis. Effective modelling of transmission will require the use of entomological indices more precise than those usually reported in the leishmaniasis literature.…”
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    Recent advances in phlebotomine sand fly research related to leishmaniasis control
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    Correction: Prevalence of Cutaneous Leishmaniasis in Districts of High and Low Endemicity in Mali
  9. 9
    “…Visceral leishmaniasis (VL) is a vector-borne disease transmitted by phlebotomine sand flies and remains the most serious form of the disease with no available human vaccine. …”
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    Vector Saliva in Vaccines for Visceral Leishmaniasis: A Brief Encounter of High Consequence?
  10. 10
    “…This is an important demonstration of vaccine protection against visceral leishmaniasis using a natural challenge model.…”
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    A defined subunit vaccine that protects against vector-borne visceral leishmaniasis
  11. 11
    “…Nevertheless, to date there is no vaccine available for human leishmaniasis. We optimized and assessed in vivo the safety and immunogenicity of an innovative vaccine candidate against human visceral leishmaniasis (VL), consisting of Virus-Like Particles (VLP) loaded with three different recombinant proteins (LJL143 from Lutzomyia longipalpis saliva as the vector-derived (VD) component, and KMP11 and LeishF3+, as parasite-derived (PD) antigens) and adjuvanted with GLA-SE, a TLR4 agonist. …”
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    Pre-clinical antigenicity studies of an innovative multivalent vaccine for human visceral leishmaniasis
  12. 12
    “…Because of the importance of SALO as a potential component of a leishmaniasis vaccine, a plan to produce this recombinant protein for future scale manufacturing as well as knowledge of its structural characteristics are needed to move SALO forward for the clinical path. …”
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    Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis
  13. 13
    “…A possible etiological link between the onset of endemic pemphigus in Tunisia and bites of Phlebotomus papatasi, the vector of zoonotic cutaneous leishmaniasis, has been previously suggested. We hypothesized that the immunodominant P. papatasi salivary protein PpSP32 binds to desmogleins 1 and 3 (Dsg1 and Dsg3), triggering loss of tolerance to these pemphigus target autoantigens. …”
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    Implicating bites from a leishmaniasis sand fly vector in the loss of tolerance in pemphigus
  14. 14
    “…Leishmaniasis is one of the top neglected tropical diseases with significant morbidity and mortality in low and middle-income countries (LMIC). …”
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    Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis
  15. 15
    “…Clinical manifestations in canine visceral leishmaniasis (CVL) have not been clearly associated with immunological status or disease progression. …”
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    Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis
  16. 16
    “…Visceral Leishmaniasis (VL), a potentially fatal disease is caused by Leishmania donovani parasites with no vaccine available. …”
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    Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis
  17. 17
    “…BACKGROUND: Reports have shown correlations between the immune response to vector saliva and Leishmaniasis outcome. We followed dogs in an endemic area for two years characterizing resistance or susceptibility to canine visceral leishmaniasis (CVL) according to Leishmania infantum diagnosis and clinical development criteria. …”
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    Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort
  18. 18
    “…Immunity to a sand fly salivary protein protects against visceral leishmaniasis (VL) in hamsters. This protection was associated with the development of cellular immunity in the form of a delayed-type hypersensitivity response and the presence of IFN-γ at the site of sand fly bites. …”
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    Sand Fly Salivary Proteins Induce Strong Cellular Immunity in a Natural Reservoir of Visceral Leishmaniasis with Adverse Consequences for Leishmania
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    Building Research and Development Capacity for Neglected Tropical Diseases Impacting Leishmaniasis in the Middle East and North Africa: A Case Study
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    “…BACKGROUND: Sand fly saliva exposure plays an important role in immunity against leishmaniasis where it has mostly been associated with protection. …”
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    The human immune response to saliva of Phlebotomus alexandri, the vector of visceral leishmaniasis in Iraq, and its relationship to sand fly exposure and infection
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