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1por Travers, Timothy, Kanagy, William K., Mansbach, Rachael A., Jhamba, Elton, Cleyrat, Cedric, Goldstein, Byron, Lidke, Diane S., Wilson, Bridget S., Gnanakaran, S.“…Experiments in reconstituted γ-KO cells, whose γ subunits are linked by disulfide bonds, as well as in cells expressing monomeric ITAM or hemITAM γ-chimeras, support model predictions that short distances between γ ITAM pairs are required for trans docking. …”
Publicado 2019
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2Antigen Geometry Tunes Mast Cell Signaling Through Distinct FcεRI Aggregation and Structural Changespor Rinaldi, Derek A., Kanagy, William K., Kaye, Hannah C., Grattan, Rachel M., Lucero, Shayna R., Pérez, Marelessis Palomino, Wester, Michael J., Lidke, Keith A., Wilson, Bridget S., Lidke, Diane S.“…Immunoreceptor tyrosine-based activation motif (ITAM)-containing Fc receptors are critical components of the innate and adaptive immune systems. …”
Publicado 2023
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3por Kanagy, William K., Cleyrat, Cédric, Fazel, Mohamadreza, Lucero, Shayna R., Bruchez, Marcel P., Lidke, Keith A., Wilson, Bridget S., Lidke, Diane S.“…Using Lyn-deficient RBL-2H3 mast cells, we found that another SFK can weakly monophosphorylate the γ-subunit, yet Syk still binds the incompletely phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs). Once recruited, Syk further enhances γ-phosphorylation to propagate signaling. …”
Publicado 2022
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