“…Focusing on the close interplay between experimental investigation of pathways and the mathematical representations of cellular dynamics, we discuss challenges and perspectives that emerge in studies of signaling systems.…”
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“…BACKGROUND: Translating a known metabolic network into a dynamic model requires rate laws for all chemical reactions. …”
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“…Such detailed investigations opened up many new areas of research in the study of spatial, complex and dynamic cellular systems. One of the crucial challenges for the study of such systems is the design of a well stuctured and optimized workflow to provide a systematic and efficient hypothesis verification. …”
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“…SensA can contribute to the analysis, adjustment and understanding of mathematical models for dynamic systems. Availability and implementation: SensA is available at http://gofid.biologie.hu-berlin.de/ and can be used with any modern browser. …”
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“…In this study, we aim at using systems biology approach to provide dynamic analysis on this pathway. …”
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“…With a view to understanding the relevance of this response to infection we have explored the dynamic regulation of thermal adaptation using an integrative systems biology approach. …”
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“…Lipid metabolism is essential for all major cell functions and has recently gained increasing attention in research and health studies. However, mathematical modeling by means of classical approaches such as stoichiometric networks and ordinary differential equation systems has not yet provided satisfactory insights, due to the complexity of lipid metabolism characterized by many different species with only slight differences and by promiscuous multifunctional enzymes. …”
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“…The complex and integrative behavior is difficult to grasp and requires mathematical modeling to fully understand the quantitative interplay of the single components within the entire system. …”
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