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1“…Using systemic bacterial infection in Drosophila melanogaster, we characterize chronic infection by three bacterial species from different genera - Providencia rettgeri, Serratia marcescens, and Enterococcus faecalis–following inoculation with a range of doses. …”
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2“…In this work, we tested for trans-generational immune priming in adult offspring of the fruit fly, Drosophila melanogaster, after maternal challenge with 10 different bacterial pathogens. …”
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3“…In the present study, we have conducted genome-wide association mapping in Drosophila melanogaster to identify the genetic basis for individual variation in resistance, and for variation in immunological sensitivity to diet (genotype-by-environment interaction, or GxE). …”
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4por Webster, Claire L., Waldron, Fergal M., Robertson, Shaun, Crowson, Daisy, Ferrari, Giada, Quintana, Juan F., Brouqui, Jean-Michel, Bayne, Elizabeth H., Longdon, Ben, Buck, Amy H., Lazzaro, Brian P., Akorli, Jewelna, Haddrill, Penelope R., Obbard, Darren J.“…Drosophila melanogaster is a valuable invertebrate model for viral infection and antiviral immunity, and is a focus for studies of insect-virus coevolution. …”
Publicado 2015
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5“…The fruit fly Drosophila melanogaster is one of the premier model organisms for studying the function and evolution of immune defense. …”
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6“…Multiple studies have shown that infection with the endosymbiotic bacterium Wolbachia pipientis confers Drosophila melanogaster and other insects with resistance to infection by RNA viruses. …”
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7“…Mating and consequent reproduction significantly reduce the ability of female Drosophila melanogaster to defend against systemic bacterial infection. …”
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8“…We performed population genetic analyses on phagocytosis and autophagy genes in Drosophila melanogaster and D. simulans to test for molecular evolutionary signatures of immune adaptation. …”
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9“…In this study, we test Drosophila melanogaster genotypes sampled from tropical Africa, temperate northeastern North America, and semi-tropical southeastern North America for resistance to bacterial infection and fecundity at three different environmental temperatures. …”
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10por Dobson, Adam J., Chaston, John M., Newell, Peter D., Donahue, Leanne, Hermann, Sara L., Sannino, David R., Westmiller, Stephanie, Wong, Adam C.-N., Clark, Andrew G., Lazzaro, Brian P., Douglas, Angela E.Enlace del recurso
Publicado 2015
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11por Shahrestani, Parvin, Chambers, Moria, Vandenberg, John, Garcia, Kelly, Malaret, Glen, Chowdhury, Pratik, Estrella, Yonathan, Zhu, Ming, Lazzaro, Brian P.“…Here we show that Drosophila melanogaster females are more likely than males to die from infection with several strains of the fungal entomopathogen Beauveria bassiana. …”
Publicado 2018
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12por Lazzaro, Brian P.“…Previous studies have shown that antiviral RNAi genes evolve extraordinarily quickly in the fruit fly Drosophila melanogaster, suggesting that they may adaptively coevolve with viruses and transposable elements. …”
Publicado 2018
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13Interactions between innate immunity and insulin signaling affect resistance to infection in insects“…In this review, we share findings that demonstrate interactions between innate immune activity and insulin signaling primarily in the insect model Drosophila melanogaster as well as other insects like Bombyx mori and Anopheles mosquitos. …”
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14por Lazzaro, Brian P.“…In the current issue of PLOS Biology, Bajgar and colleagues elegantly demonstrate the energetic and life history cost of the immune response that Drosophila melanogaster larvae induce after infection by the parasitoid wasp Leptopilina boulardi. …”
Publicado 2015
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15“…As a model, we infected the host Drosophila melanogaster with a horizontally transmitted, extracellular bacterial pathogen, Providencia rettgeri. …”
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16“…It is now well established that natural populations of Drosophila melanogaster harbor substantial genetic variation associated with physiological measures of immune function. …”
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17“…The response to bacterial infection in Drosophila melanogaster has been classically described in studies that focused on the immune response elicited by a small set of largely avirulent microbes. …”
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18por Rombaut, Antoine, Gallet, Romain, Qitout, Kenza, Samy, Mukherjy, Guilhot, Robin, Ghirardini, Pauline, Lazzaro, Brian P., Becher, Paul G., Xuéreb, Anne, Gibert, Patricia, Fellous, Simon“…We studied competition between two insect species, the invasive pest Drosophila suzukii and the model Drosophila melanogaster, whose larval ecological niches overlap in ripe, but not rotten, fruit. …”
Publicado 2023
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19por Duneau, David F., Kondolf, Hannah C., Im, Joo Hyun, Ortiz, Gerardo A., Chow, Christopher, Fox, Michael A., Eugénio, Ana T., Revah, J., Buchon, Nicolas, Lazzaro, Brian P.“…Here, we used Drosophila melanogaster to assess and dissect sexual dimorphism in the innate response to systemic bacterial infection. …”
Publicado 2017
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20“…RESULTS: Using single-nucleus sequencing, we determined that the Drosophila melanogaster fat body executes diverse basal functions with heterogenous cellular subpopulations. …”
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