“…SIMPLE SUMMARY: As an indigenous animal living in the Tibetan plateau, the Tibetan sheep is well adapted to high-altitude hypoxia, and the lungs play an important role in overcoming the hypoxic environment. …”
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“…Altitude is the main external environmental pressure affecting the production performance of Tibetan sheep, and the adaptive evolution of many years has formed a certain response mechanism. …”
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“…The Tibetan sheep is an indigenous species on the Tibetan plateau with excellent adaptability to high-altitude hypoxia and is distributed at altitudes of 2500–5000 m. …”
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“…SIMPLE SUMMARY: This study intended to understand the variation in egg and clutch mass among coexisting bird species at high altitudes. We investigated several life-history or ecological factors that could explain this variation. …”
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“…SIMPLE SUMMARY: Hypoxia-inducible factors (HIFs) play an important role in the adaptation of animals to high-altitude hypoxia. In high-altitude indigenous species, variation in the hypoxia-inducible factor-1 alpha (HIF-1α) gene has been reported in Tibetans, yaks and Tibetan horses, but has not been investigated in Tibetan sheep, and is not known if it might affect high-altitude hypoxia adaptation in these sheep. …”
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“…By analyzing mitochondrial dynamics, mitochondrial fusion was shown to be significantly increased and fission significantly decreased in the heart with increasing altitude (p < 0.05). There was a significant increase in the density of the mitochondria, and a significant decrease in the average area, aspect ratio, number, and width of single mitochondrial cristae with increasing altitudes (p < 0.05). …”
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“…RT-qPCR results showed that EPAS1 was expressed in the six tissues of Hu sheep and Tibetan sheep at different altitudes. In addition, the expression of EPAS1 in four tissues (heart, liver, spleen, and longissimus dorsi muscle) of Hu sheep was lower than that in Tibetan sheep from three different altitudes, and the expression of EPAS1 was positively correlated with the altitude. …”
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“…This study was conducted to evaluate the differences of glycolysis and heat shock proteins (HSPs) in Gannan yaks (Bos grunniens), with the main goal of understanding how the response to hypoxia changes with altitude. Here, the genes and enzymes of glycolysis and HSPs were detected in heart, liver, lung, kidney, and longissimus dorsi from Gannan yaks at different altitude (2500 and 3500  [Formula: see text]) using qPCR, western blot, and enzyme kits. …”
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“…Therefore, the characteristics of the rumen microbiome and metabolome, transcriptome, and serum metabolome of Tibetan sheep at different altitudes (4500 m, 3500 m, and 2500 m) were analyzed. …”
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“…SIMPLE SUMMARY: The Qinghai-Tibet Plateau has a unique ecological environment, involving high altitude, low oxygen levels, strong ultraviolet rays, and severe imbalances in seasonal forage supply, which poses a serious threat to the livestock that feeds on natural pastures to maintain their survival. …”
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“…In this study, we conducted both conventional and phylogenetically controlled analyses to investigate whether nest concealment affected several reproductive traits across 21 sympatric bird species living on Tibet Plateau (3,400 m altitude). Qualitatively equivalent results were reached in analyses, regardless of phylogenetic controls. …”
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“…These data provide value for further studies on molecular evolution and conservation genetics on these poorly-known Leptopoecile species at high altitudes.…”
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“…SIMPLE SUMMARY: Mitochondria play a crucial role in the adaptation to high altitude hypoxia environment in Tibetan sheep, and the changes of its morphology and structure directly affect its function. …”
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“…In conclusion, the host genome and rumen microbiome of Tibetan sheep co-encoded a certain glycoside hydrolase (β-glucosidase) and coevolved efficient VFA transport functions and amino acid anabolic processes; thus, helping Tibetan sheep adapt to nutrient stress in the cold season in high-altitude areas.…”
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“…Cattle-yak, a hybrid offspring of yak (Bos grunniens) and cattle (Bos taurus), inhabit the Qinghai-Tibet Plateau at an altitude of more than 3,000 m and obtain nutrients predominantly through grazing on natural pastures. …”
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“…SIMPLE SUMMARY: The Tianzhu white yaks is a unique species living on the Qinghai–Tibet Plateau and has strong adaptability to high altitude and low oxygen. These yaks mainly rely on natural pasture as the source of nutrients. …”
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