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2por Tong, Yexin, Sun, Mingjun, Chen, Lingli, Wang, Yunzhi, Li, Yan, Li, Lingling, Zhang, Xuan, Cai, Yumeng, Qie, Jingbo, Pang, Yanrui, Xu, Ziyan, Zhao, Jiangyan, Zhang, Xiaolei, Liu, Yang, Tian, Sha, Qin, Zhaoyu, Feng, Jinwen, Zhang, Fan, Zhu, Jiajun, Xu, Yifan, Lou, Wenhui, Ji, Yuan, Zhao, Jianyuan, He, Fuchu, Hou, Yingyong, Ding, Chen“…In vivo functional experiments were performed to further illustrate the biological events related to PDAC tumorigenesis and progression. …”
Publicado 2022
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3por Chen, Lilan, Zhu, Chunyan, Pan, Fan, Chen, Ying, Xiong, Lei, Li, Yan, Chu, Xiaoyuan, Huang, Guichun“…Their effects on tumor biology are gradually figured out. According to updated cancer hallmarks, we reviewed the biological effects of platelets on tumors, including regulating tumor proliferation and growth, promoting cancer invasion and metastasis, inducing vasculature, avoiding immune destruction, and mediating tumor metabolism and inflammation.…”
Publicado 2023
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4“…To comprehensively demonstrate the biosynthetic process and molecular features of MUC2 and to provide new directions for the development of PMP mucolytic strategies, this review systematically summarizes the molecular biology of MUC2, including MUC2 gene structure, transcription, translation, post-translational modification, tertiary structure, and factors regulating mucus viscoelasticity. …”
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5“…The findings presented here demonstrate the utility of the zebrafish models for the further investigation of cancer biology and the development of novel and improved therapies. …”
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6por Li, Yan, Han, Li-Rong, Zhang, Yuanyuan, Fu, Xuechi, Chen, Xinyi, Zhang, Lixia, Mei, Ruhong, Wang, QiEnlace del recurso
Publicado 2013
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7“…Thus, multiple changes commonly occur in biological sequences and play crucial roles in maintaining conformational and functional stability. …”
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8“…CONCLUSION: GNAS mutation is one of the most important molecular biological features in PMP, with major functions to promote mucin hypersecretion.…”
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9por Geng, Shuangshuang, Chen, Haijiao, Li, Yan, Li, Ying, Pang, Jingxiang, Zhang, Feipeng, Qu, Zhiqiang, Li, Mengjun, Liu, Na, Yao, Qingqiang, Mu, Yanling, Liu, BoEnlace del recurso
Publicado 2022
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12“…Genome-scale CRISPR-Cas9 knockout (KO) screen study also facilitates the identification of novel genes in which loss alters drug permeability across biological membranes and thus modulates the efficacy and safety of drugs. …”
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13“…BACKGROUND: This review systematically summarizes gene biology features and protein structure of nucleoplasmin2 (NPM2) and the relationship between NPM2 and malignant peritoneal mesothelioma (MPM), in order to explore the molecular pathological mechanism of MPM and explore new therapeutic targets. …”
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14por Zheng, Jiahui, Wu, Min, Wang, Haiyan, Li, Shasha, Wang, Xin, Li, Yan, Wang, Dong, Li, Shao“…However, the commonness in the biological basis of health-strengthening herbs remains to be holistically elucidated. …”
Publicado 2018
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15por Zi, Cheng-Ting, Gao, Ying-Sheng, Yang, Liu, Feng, Shu-Yun, Huang, Yue, Sun, Li, Jin, Yi, Xu, Feng-Qing, Dong, Fa-Wu, Li, Yan, Ding, Zhong-Tao, Zhou, Jun, Jiang, Zi-Hua, Yuan, Sheng-Tao, Hu, Jiang-MiaoEnlace del recurso
Publicado 2019
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16“…Here, we propose a network pharmacology strategy integrating computational, clinical, and experimental investigation to study the biological basis of SQD syndrome. From computational aspects, we used a powerful disease gene prediction algorithm to predict the SQD syndrome biomolecular network which is significantly enriched in biological functions including immune regulation, oxidative stress, and lipid metabolism. …”
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18“…In this perspective, this paper represents the first review to provide a comprehensive description of α-carbolines including natural products, updated literature of synthesis, and their diverse biological activities. Their biological activities including antitumor, anti-microbial, anti-Alzheimer’s disease, anti-atherosclerosis, and antioxidant activities were hilighted. …”
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20“…To address this question, a novel systems biology model integrating oral bioavailability and drug-likeness screening, target identification, and network pharmacology method has been constructed and applied to four clinically widely used herbs Radix Astragali Mongolici, Radix Puerariae Lobatae, Radix Ophiopogonis Japonici, and Radix Salviae Miltiorrhiza which exert synergistic effects of combined treatment of cardiovascular disease (CVD). …”
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