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  1. 1
    “…In recent years, an increasing number of people have migrated to high-altitude areas for work and study. Headache, sleep disturbance, and cognitive impairment from HH, severely challenges the physical and mental health and affects their quality of life and work efficiency. …”
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    Mechanism, prevention and treatment of cognitive impairment caused by high altitude exposure
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    “…Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. …”
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    Convergent genomic signatures of high-altitude adaptation among domestic mammals
  3. 3
    “…The high-altitude hypoxic environment represents one of the most extreme challenges for mammals. …”
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    Genetic Convergence in the Adaptation of Dogs and Humans to the High-Altitude Environment of the Tibetan Plateau
  4. 4
    “…Due to the influence of altitude change on a driver’s heart rate, it is difficult to estimate driving fatigue using heart rate variability (HRV) at a road segment with frequent and rapid altitude change. …”
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    Estimating Driving Fatigue at a Plateau Area with Frequent and Rapid Altitude Change
  5. 5
    “…High-altitude acclimatization is a representative example of vertebrates’ acclimatization to harsh and extreme environments. …”
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    Comparative microRNA Transcriptomes in Domestic Goats Reveal Acclimatization to High Altitude
  6. 6
    “…OBJECTIVE: The primary objective of this study is to investigate the prevalence and risk factors of stroke in high-altitude areas through a comprehensive systematic review and meta-analysis. …”
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    Prevalence and risk factors of stroke in high-altitude areas: a systematic review and meta-analysis
  7. 7
    “…The slopes increased significantly with altitude, it varied from less than 1 at low altitude to more than 1 at high altitude. …”
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    The Scaling Relationships between Leaf Mass and Leaf Area of Vascular Plant Species Change with Altitude
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    “…It is well known that humans physiologically or pathologically respond to high altitude, with these responses accompanied by alterations in the gut microbiome. …”
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    Gut Microbiome-Targeted Modulations Regulate Metabolic Profiles and Alleviate Altitude-Related Cardiac Hypertrophy in Rats
  9. 9
    “…Goat is one of the first domesticated species and has evolved rapidly to adapt to diverse environments, including harsh high-altitude conditions with low temperature and poor oxygen supply but strong ultraviolet radiation. …”
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    Markhor-derived Introgression of a Genomic Region Encompassing PAPSS2 Confers High-altitude Adaptability in Tibetan Goats
  10. 10
    “…Cold and hypoxia are critical drivers of adaptation to high altitudes. Organisms at high altitudes have adapted to maximize the efficiency of oxygen utilization and are less prone to obesity and diabetes than those at low altitudes. …”
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    Adipose-derived exosomal miR-210/92a cluster inhibits adipose browning via the FGFR-1 signaling pathway in high-altitude hypoxia
  11. 11
    “…BACKGROUND: Weather change in high-altitude areas subjects mature tobacco (Nicotiana tabacum L.) to cold stress, which damages tobacco leaf yield and quality. …”
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    Cold stress in the harvest period: effects on tobacco leaf quality and curing characteristics
  12. 12
    “…We further identified strong signatures of selection affecting genomic regions that harbor genes underlying economic traits (typically related to feathers, skin color, growth, reproduction and aggressiveness) and local adaptation (to high altitude). By comparing the genomes of the Tibetan and lowland fowls, we identified genes associated with high-altitude adaptation in Tibetan chickens were mainly involved in energy metabolism, body size maintenance and available food sources. …”
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    Population genomics identifies patterns of genetic diversity and selection in chicken
  13. 13
    “…OBJECTIVE: This study aims to investigate the effects of TRPV4 on acute hypoxic exercise-induced central fatigue, in order to explore the mechanism in central for exercise capacity decline of athletes in the early stage of altitude training. METHODS: 120 male Wistar rats were randomly divided into 12 groups: 4 normoxia groups (quiet group, 5-level group, 8-level group, exhausted group), 4 groups at simulated 2500 m altitude (grouping as before), 4 groups at simulated 4500 m altitude (grouping as before), 10 in each group. …”
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    TRPV4 plays an important role in rat prefrontal cortex changes induced by acute hypoxic exercise
  14. 14
    “…Population genomics analysis of 147 T. urartu accessions from across the Fertile Crescent showed clustering of three groups, with differences in altitude and biostress, such as powdery mildew disease. …”
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    Genome sequence of the progenitor of wheat A subgenome Triticum urartu
  15. 15
    “…These findings demonstrate that compared with P. jezoensis, B. ermanii has a higher soluble sugars/starch ratio, and its shoots, stems and fine roots actively store NSC to adapt to the harsh environment, which is one of the reasons that B. ermanii can be distributed at higher altitudes.…”
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    Non-Structural Carbohydrate Storage Strategy Explains the Spatial Distribution of Treeline Species
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    “…By combining two approaches, ZH(p) and di values, we identified 22 genomic regions that may have contributed to the phenotypes in coat color patterns, body size, cashmere traits, as well as high altitude adaptation in goat populations. Candidate genes underlying strong selection signatures including coloration (ASIP, KITLG, HTT, GNA11, and OSTM1), body size (TBX15, DGCR8, CDC25A, and RDH16), cashmere traits (LHX2, FGF9, and WNT2), and hypoxia adaptation (CDK2, SOCS2, NOXA1, and ENPEP) were identified. …”
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    Whole-genome sequencing of eight goat populations for the detection of selection signatures underlying production and adaptive traits
  17. 17
    “…The increased food intake of the giant pandas might be a strategy to compensate for the gut microbiome functions, highlighting a strong need of conservation of the native bamboo forest both in high- and low-altitude ranges to meet the great demand of bamboo diet of giant pandas.…”
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    Metagenomic Study Suggests That the Gut Microbiota of the Giant Panda (Ailuropoda melanoleuca) May Not Be Specialized for Fiber Fermentation
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    “…The evaluation outcomes of the MaxEnt model revealed that the total and highly suitable areas of PWD will expand substantially by both 2050 and 2070, and the potential distribution of PWD will have a tendency to spread towards high altitudes and latitudes.…”
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    Predicting the Potential Distribution of Pine Wilt Disease in China under Climate Change
  19. 19
    “…BACKGROUND: The plateau pika (Ochotona curzoniae) is a small rabbit-like mammal that lives at high altitudes in the Qinghai-Tibet plateau and is in close contact with birds. …”
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    Distribution of sialic acid receptors and experimental infections with different subtypes of influenza A viruses in Qinghai-Tibet plateau wild pika
  20. 20
    “…SIMPLE SUMMARY: The yak is a unique species found on the Tibetan plateau, adapted to the high-altitude, low-oxygen environment, providing meat, milk, and other resources to local herders, and is an indispensable means of production and livelihood for herders on the Tibetan plateau and a major source of economic income for Tibetan herders. …”
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    Ruminal Fluid Transplantation Accelerates Rumen Microbial Remodeling and Improves Feed Efficiency in Yaks
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