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1por Consolino, Lorena, Anemone, Annasofia, Capozza, Martina, Carella, Antonella, Irrera, Pietro, Corrado, Alessia, Dhakan, Chetan, Bracesco, Martina, Longo, Dario Livio“…This mini-review describes CEST-based methods to non-invasively investigate tumor metabolism and important metabolites involved, such as glucose and lactate, as well as measurement of tumor acidosis. …”
Publicado 2020
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2por Villano, Daisy, Romdhane, Feriel, Irrera, Pietro, Consolino, Lorena, Anemone, Annasofia, Zaiss, Moritz, Dastrù, Walter, Longo, Dario Livio“…To overcome these limitations, we propose a fast multislice CEST‐MRI sequence with high pH accuracy and spatial resolution. …”
Publicado 2020
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3por Jardim-Perassi, Bruna Victorasso, Irrera, Pietro, Lau, Justin Y. C., Budzevich, Mikalai, Whelan, Christopher J., Abrahams, Dominique, Ruiz, Epifanio, Ibrahim-Hashim, Arig, Damgaci Erturk, Sultan, Longo, Dario Livio, Pilon-Thomas, Shari A., Gillies, Robert J.“…Chemical exchange saturation transfer-magnetic resonance imaging (CEST-MRI) is a noninvasive technique that can measure pH in vivo using pH-sensitive contrast agents. …”
Publicado 2023
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4por Anemone, Annasofia, Consolino, Lorena, Conti, Laura, Irrera, Pietro, Hsu, Myriam Y., Villano, Daisy, Dastrù, Walter, Porporato, Paolo E., Cavallo, Federica, Longo, Dario Livio“…MRI-CEST pH imaging successfully discriminated the more aggressive 4T1 and TS/A tumours that displayed a more acidic pH. …”
Publicado 2020
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5por Zaiss, Moritz, Anemone, Annasofia, Goerke, Steffen, Longo, Dario Livio, Herz, Kai, Pohmann, Rolf, Aime, Silvio, Rivlin, Michal, Navon, Gil, Golay, Xavier, Scheffler, Klaus“…AIMS: To determine individual glucose hydroxyl exchange rates at physiological conditions and use this information for numerical optimization of glucoCEST/CESL preparation. To give guidelines for in vivo glucoCEST/CESL measurement parameters at clinical and ultra‐high field strengths. …”
Publicado 2019
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6por Irrera, Pietro, Consolino, Lorena, Roberto, Miriam, Capozza, Martina, Dhakan, Chetan, Carella, Antonella, Corrado, Alessia, Villano, Daisy, Anemone, Annasofia, Navarro-Tableros, Victor, Bracesco, Martina, Dastrù, Walter, Aime, Silvio, Longo, Dario Livio“…In conclusion, this work shows that MRI-CEST tumor pH imaging is a valuable tool for assessing the in vivo treatment response to PPIs.…”
Publicado 2022
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7por Irrera, Pietro, Roberto, Miriam, Consolino, Lorena, Anemone, Annasofia, Villano, Daisy, Navarro-Tableros, Victor, Carella, Antonella, Dastrù, Walter, Aime, Silvio, Longo, Dario Livio“…Overall, this study highlights MRI-CEST tumor pH imaging as a valid approach to monitoring treatment response to PPIs.…”
Publicado 2022
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8por Anemone, Annasofia, Capozza, Martina, Arena, Francesca, Zullino, Sara, Bardini, Paola, Terreno, Enzo, Longo, Dario Livio, Aime, Silvio“…The current study deals with the assessment of the effect of pH, saturation power level (B(1)) and magnetic field strength (B(0)) on the MRI‐CEST contrast with the aim of comparing the in vivo CEST contrast detectability of these two agents in the glucoCEST procedure. …”
Publicado 2021
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9por Dhakan, Chetan, Anemone, Annasofia, Ventura, Vittoria, Carella, Antonella, Corrado, Alessia, Pirotta, Elisa, Villano, Daisy, Romdhane, Feriel, Gammaraccio, Francesco, Aime, Silvio, Longo, Dario Livio“…Our results suggested that MRI-CEST tumor pH imaging can monitor the therapeutic efficacy of PPIs in breast cancer murine models.…”
Publicado 2023
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10por Kim, Mina, Eleftheriou, Afroditi, Ravotto, Luca, Weber, Bruno, Rivlin, Michal, Navon, Gil, Capozza, Martina, Anemone, Annasofia, Longo, Dario Livio, Aime, Silvio, Zaiss, Moritz, Herz, Kai, Deshmane, Anagha, Lindig, Tobias, Bender, Benjamin, Golay, Xavier“…To date, dynamic glucose-enhanced (DGE) MRI using glucose-based chemical exchange saturation transfer (glucoCEST) has demonstrated the sensitivity to detect both d-glucose and glucose analogs, such as 3-oxy-methyl-d-glucose (3OMG) uptake in tumors. …”
Publicado 2022
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11por Avnet, Sofia, Lemma, Silvia, Cortini, Margherita, Di Pompo, Gemma, Perut, Francesca, Lipreri, Maria Veronica, Roncuzzi, Laura, Columbaro, Marta, Errani, Costantino, Longhi, Alessandra, Zini, Nicoletta, Heymann, Dominique, Dominici, Massimo, Grisendi, Giulia, Golinelli, Giulia, Consolino, Lorena, Longo, Dario Livio, Nanni, Cristina, Righi, Alberto, Baldini, Nicola“…In vivo subcutaneous and orthotopic models, co-injected with mesenchymal stromal (MSC) and osteosarcoma cells, formed an acidic tumour microenvironment (mean pH 6.86, as assessed by in vivo MRI-CEST pH imaging). In these xenografts, we enlightened the expression of both IL6 and the NF-kB complex subunit in stromal cells infiltrating the tumour acidic area. …”
Publicado 2021
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