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1por Maeso-Alonso, Laura, López-Ferreras, Lorena, Marques, Margarita M., Marin, Maria C.“…In this work, we will review the current understanding of p73 role as a neurogenic niche architect through the regulation of cell adhesion, cytoskeleton dynamics and Planar Cell Polarity, and give a general overview of TAp73 as a hub modulator of these functions, whose alteration could impinge in many of the Trp73(–/–) phenotypes.…”
Publicado 2021
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2por Maeso-Alonso, Laura, Alonso-Olivares, Hugo, Martínez-García, Nicole, López-Ferreras, Lorena, Villoch-Fernández, Javier, Puente-Santamaría, Laura, Colas-Algora, Natalia, Fernández-Corona, Alfonso, Lorenzo-Marcos, María Elena, Jiménez, Benilde, Holmgren, Lars, Wilhelm, Margareta, Millan, Jaime, del Peso, Luis, Claesson-Welsh, Lena, Marques, Margarita M., Marin, Maria C.“…Here, we uncover TAp73 transcription factor as a vascular architect that orchestrates transcriptional programs involved in cell junction establishment and developmental blood vessel morphogenesis and identify Angiomotin (AMOT) as a TAp73 direct transcriptional target. …”
Publicado 2022
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3por Marques, Margarita M., Villoch-Fernandez, Javier, Maeso-Alonso, Laura, Fuertes-Alvarez, Sandra, Marin, Maria C.“…Thus, loss of ciliary biogenesis and epithelial organization might be a common underlying cause of the diverse p73KO-phenotypes, highlighting Trp73 role as an architect of the epithelial tissue. In this review we would like to discuss the data regarding p73 role as regulator of ependymal cell ciliogenesis and PCP, supporting the view of the Trp73-mutant mice as a model that uncouples ciliogenesis from PCP and a possible model of human congenital hydrocephalus.…”
Publicado 2019
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4por Fuertes-Alvarez, Sandra, Maeso-Alonso, Laura, Villoch-Fernandez, Javier, Wildung, Merit, Martin-Lopez, Marta, Marshall, Clayton, Villena-Cortes, Alberto J., Diez-Prieto, Inmaculada, Pietenpol, Jennifer A., Tissir, Fadel, Lizé, Muriel, Marques, Margarita M., Marin, Maria C.“…These results shed light into the mechanism of ependymal cell planar polarization and reveal p73 as an epithelial architect during development regulating the cellular cytoskeleton.…”
Publicado 2018
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