-
1por Yang, Ya-Ting, Zhong, Xiaomin, Fahmi, Ali, Watts, Simon, Ashcroft, Darren M., Massey, Jon, Fisher, Louis, MacKenna, Brian, Mehrkar, Amir, Bacon, Sebastian C. J., Goldacre, Ben, Hand, Kieran, van Staa, Tjeerd, Palin, Victoria“…METHODS: With the approval of NHS England, a retrospective cohort study using the OpenSAFELY platform analysed routinely collected electronic health data from GP practices in England between January 2019 and December 2021. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
2por Andrews, Colm, Schultze, Anna, Curtis, Helen, Hulme, William, Tazare, John, Evans, Stephen, Mehrkar, Amir, Bacon, Sebastian, Hickman, George, Bates, Christopher, Parry, John, Hester, Frank, Harper, Sam, Cockburn, Jonathan, Evans, David, Ward, Tom, Davy, Simon, Inglesby, Peter, Goldacre, Ben, MacKenna, Brian, Tomlinson, Laurie, Walker, Alex“…OpenSAFELY-TPP data is derived from practices in England using SystmOne software, and has been used for the majority of these studies. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3por Zhong, Xiaomin, Pate, Alexander, Yang, Ya-Ting, Fahmi, Ali, Ashcroft, Darren M., Goldacre, Ben, MacKenna, Brian, Mehrkar, Amir, Bacon, Sebastian C.J., Massey, Jon, Fisher, Louis, Inglesby, Peter, Hand, Kieran, van Staa, Tjeerd, Palin, Victoria“…METHODS: With the approval of NHS England, we used OpenSAFELY platform to access the TPP SystmOne electronic health record (EHR) system and selected patients prescribed antibiotics from 2019 to 2021. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4por Forbes, Harriet, Morton, Caroline E, Bacon, Seb, McDonald, Helen I, Minassian, Caroline, Brown, Jeremy P, Rentsch, Christopher T, Mathur, Rohini, Schultze, Anna, DeVito, Nicholas J, MacKenna, Brian, Hulme, William J, Croker, Richard, Walker, Alex J, Williamson, Elizabeth J, Bates, Chris, Mehrkar, Amir, Curtis, Helen J, Evans, David, Wing, Kevin, Inglesby, Peter, Drysdale, Henry, Wong, Angel Y S, Cockburn, Jonathan, McManus, Robert, Parry, John, Hester, Frank, Harper, Sam, Douglas, Ian J, Smeeth, Liam, Evans, Stephen J W, Bhaskaran, Krishnan, Eggo, Rosalind M, Goldacre, Ben, Tomlinson, Laurie A“…DESIGN: Population based cohort study, on behalf of NHS England. SETTING: Primary care data and pseudonymously linked hospital and intensive care admissions and death records from England, during wave 1 (1 February to 31 August 2020) and wave 2 (1 September to 18 December 2020). …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
5por Lemanska, Agnieszka, Andrews, Colm, Fisher, Louis, Butler-Cole, Ben, Mehrkar, Amir, Roberts, Keith J, Goldacre, Ben, Walker, Alex J, MacKenna, Brian“…DATA SOURCES: With the approval of NHS England, we conducted this study using 24 million electronic healthcare records of people within the OpenSAFELY-TPP research platform. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
6por Curtis, Helen J, MacKenna, Brian, Wiedemann, Milan, Fisher, Louis, Croker, Richard, Morton, Caroline E, Inglesby, Peter, Walker, Alex J, Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian CJ, Hickman, George, Evans, David, Ward, Tom, Davy, Simon, Hulme, William J, Macdonald, Orla, Conibere, Robin, Lewis, Tom, Myers, Martin, Wanninayake, Shamila, Collison, Kiren, Drury, Charles, Samuel, Miriam, Sood, Harpreet, Cipriani, Andrea, Fazel, Seena, Sharma, Manuj, Baqir, Wasim, Bates, Chris, Parry, John, Goldacre, Ben“…DESIGN AND SETTING: With the approval of NHS England, a cohort study was conducted of 23.8 million patient records in general practice, in situ using OpenSAFELY. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
7por Tazare, John, Walker, Alex J., Tomlinson, Laurie A., Hickman, George, Rentsch, Christopher T., Williamson, Elizabeth J., Bhaskaran, Krishnan, Evans, David, Wing, Kevin, Mathur, Rohini, Wong, Angel YS., Schultze, Anna, Bacon, Seb, Bates, Chris, Morton, Caroline E., Curtis, Helen J., Nightingale, Emily, McDonald, Helen I., Mehrkar, Amir, Inglesby, Peter, Davy, Simon, MacKenna, Brian, Cockburn, Jonathan, Hulme, William J., Warren-Gash, Charlotte, Bhate, Ketaki, Nitsch, Dorothea, Powell, Emma, Mulick, Amy, Forbes, Harriet, Minassian, Caroline, Croker, Richard, Parry, John, Hester, Frank, Harper, Sam, Eggo, Rosalind M., Evans, Stephen JW., Smeeth, Liam, Douglas, Ian J, Goldacre, Ben“…Methods: Working on behalf of NHS England, we used linked primary care records, death certificate and hospital data from the OpenSAFELY platform. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
8por Lemanska, Agnieszka, Andrews, Colm, Fisher, Louis, Bacon, Seb, Frampton, Adam E, Mehrkar, Amir, Inglesby, Peter, Davy, Simon, Roberts, Keith, Patalay, Praveetha, Goldacre, Ben, MacKenna, Brian, Walker, Alex J“…METHODS: With the approval of NHS England, and drawing from a nationally representative OpenSAFELY-TPP dataset of 24 million patients (over 40% of the English population), we undertook a cohort study of people diagnosed with pancreatic cancer. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
9por Curtis, Helen J, MacKenna, Brian, Croker, Richard, Inglesby, Peter, Walker, Alex J, Morley, Jessica, Mehrkar, Amir, Morton, Caroline E, Bacon, Seb, Hickman, George, Bates, Chris, Evans, David, Ward, Tom, Cockburn, Jonathan, Davy, Simon, Bhaskaran, Krishnan, Schultze, Anna, Rentsch, Christopher T, Williamson, Elizabeth J, Hulme, William J, McDonald, Helen I, Tomlinson, Laurie, Mathur, Rohini, Drysdale, Henry, Eggo, Rosalind M, Wing, Kevin, Wong, Angel YS, Forbes, Harriet, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen JW, Douglas, Ian J, Smeeth, Liam, Goldacre, Ben“…DESIGN AND SETTING: Working on behalf of NHS England, a cohort study was conducted of 23.8 million patient records in general practice, in situ using OpenSAFELY. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
10por Walker, Jemma L, Schultze, Anna, Tazare, John, Tamborska, Arina, Singh, Bhagteshwar, Donegan, Katherine, Stowe, Julia, Morton, Caroline E, Hulme, William J, Curtis, Helen J, Williamson, Elizabeth J, Mehrkar, Amir, Eggo, Rosalind M, Rentsch, Christopher T, Mathur, Rohini, Bacon, Sebastian, Walker, Alex J, Davy, Simon, Evans, David, Inglesby, Peter, Hickman, George, MacKenna, Brian, Tomlinson, Laurie, CA Green, Amelia, Fisher, Louis, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Bates, Christopher, Evans, Stephen JW, Solomon, Tom, Andrews, Nick J, Douglas, Ian J, Goldacre, Ben, Smeeth, Liam, McDonald, Helen I“…METHODS: With the approval of NHS England we analysed primary care data from >17 million patients in England linked to emergency care, hospital admission and mortality records in the OpenSAFELY platform. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
11por Green, Amelia, Curtis, Helen, Hulme, William, Williamson, Elizabeth, McDonald, Helen, Bhaskaran, Krishnan, Rentsch, Christopher, Schultze, Anna, MacKenna, Brian, Mahalingasivam, Viyaasan, Tomlinson, Laurie, Walker, Alex, Fisher, Louis, Massey, Jon, Andrews, Colm, Hopcroft, Lisa, Morton, Caroline, Croker, Richard, Morley, Jessica, Mehrkar, Amir, Bacon, Seb, Evans, David, Inglesby, Peter, Hickman, George, Ward, Tom, Davy, Simon, Mathur, Rohini, Tazare, John, Eggo, Rosalind, Wing, Kevin, Wong, Angel, Forbes, Harriet, Bates, Chris, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Douglas, Ian, Evans, Stephen, Smeeth, Liam, Goldacre, Ben“…CONCLUSIONS: While the majority of COVID-19 vaccine breakthrough cases in England were mild, some differences in rates of breakthrough cases have been identified in several clinical groups. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
12por Grint, Daniel J, Wing, Kevin, Williamson, Elizabeth, McDonald, Helen I, Bhaskaran, Krishnan, Evans, David, Evans, Stephen JW, Walker, Alex J, Hickman, George, Nightingale, Emily, Schultze, Anna, Rentsch, Christopher T, Bates, Chris, Cockburn, Jonathan, Curtis, Helen J, Morton, Caroline E, Bacon, Sebastian, Davy, Simon, Wong, Angel YS, Mehrkar, Amir, Tomlinson, Laurie, Douglas, Ian J, Mathur, Rohini, Blomquist, Paula, MacKenna, Brian, Ingelsby, Peter, Croker, Richard, Parry, John, Hester, Frank, Harper, Sam, DeVito, Nicholas J, Hulme, Will, Tazare, John, Goldacre, Ben, Smeeth, Liam, Eggo, Rosalind M“…We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34–2.09; p < 0.0001). …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
13por Grint, Daniel J, Wing, Kevin, Houlihan, Catherine, Gibbs, Hamish P, Evans, Stephen J W, Williamson, Elizabeth, McDonald, Helen I, Bhaskaran, Krishnan, Evans, David, Walker, Alex J, Hickman, George, Nightingale, Emily, Schultze, Anna, Rentsch, Christopher T, Bates, Chris, Cockburn, Jonathan, Curtis, Helen J, Morton, Caroline E, Bacon, Sebastian, Davy, Simon, Wong, Angel Y S, Mehrkar, Amir, Tomlinson, Laurie, Douglas, Ian J, Mathur, Rohini, MacKenna, Brian, Ingelsby, Peter, Croker, Richard, Parry, John, Hester, Frank, Harper, Sam, DeVito, Nicholas J, Hulme, Will, Tazare, John, Smeeth, Liam, Goldacre, Ben, Eggo, Rosalind M“…METHODS: With the approval of NHS England, we linked individual-level data from primary care with SARS-CoV-2 community testing, hospital admission, and Office for National Statistics all-cause death data. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
14por Russell, Mark D, Galloway, James B, Andrews, Colm D, MacKenna, Brian, Goldacre, Ben, Mehrkar, Amir, Curtis, Helen J, Butler-Cole, Ben, O'Dwyer, Thomas, Qureshi, Sumera, Ledingham, Joanna M, Mahto, Arti, Rutherford, Andrew I, Adas, Maryam A, Alveyn, Edward, Norton, Sam, Cope, Andrew P, Bechman, Katie“…Our objective was to use OpenSAFELY to assess the effects of the pandemic on diagnostic incidence and care delivery for inflammatory arthritis in England and to replicate key metrics from the National Early Inflammatory Arthritis Audit. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
15por Hulme, William J, Horne, Elsie M F, Parker, Edward P K, Keogh, Ruth H, Williamson, Elizabeth J, Walker, Venexia, Palmer, Tom M, Curtis, Helen J, Walker, Alex J, Andrews, Colm D, Mehrkar, Amir, Morley, Jessica, MacKenna, Brian, Bacon, Sebastian C J, Goldacre, Ben, Hernán, Miguel A, Sterne, Jonathan A C“…OBJECTIVE: To compare the effectiveness of the BNT162b2 mRNA (Pfizer-BioNTech) and mRNA-1273 (Moderna) covid-19 vaccines during the booster programme in England. DESIGN: Matched cohort study, emulating a comparative effectiveness trial. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
16por Nab, Linda, Parker, Edward P K, Andrews, Colm D, Hulme, William J, Fisher, Louis, Morley, Jessica, Mehrkar, Amir, MacKenna, Brian, Inglesby, Peter, Morton, Caroline E, Bacon, Sebastian C J, Hickman, George, Evans, David, Ward, Tom, Smith, Rebecca M, Davy, Simon, Dillingham, Iain, Maude, Steven, Butler-Cole, Ben F C, O’Dwyer, Thomas, Stables, Catherine L, Bridges, Lucy, Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Zheng, Bang, Williamson, Elizabeth J, Eggo, Rosalind M, Evans, Stephen J W, Goldacre, Ben, Tomlinson, Laurie A, Walker, Alex J“…METHODS: We did a retrospective cohort study in England using the OpenSAFELY platform with the approval of National Health Service England, covering the first five SARS-CoV-2 pandemic waves (wave one [wild-type] from March 23 to May 30, 2020; wave two [alpha (B.1.1.7)] from Sept 7, 2020, to April 24, 2021; wave three [delta (B.1.617.2)] from May 28 to Dec 14, 2021; wave four [omicron (B.1.1.529)] from Dec 15, 2021, to April 29, 2022; and wave five [omicron] from June 24 to Aug 3, 2022). …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
17por Hopcroft, Lisa E., Curtis, Helen J., Brown, Andrew D., Hulme, William J., Andrews, Colm D., Morton, Caroline E., Inglesby, Peter, Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian C., Eggo, Rosalind M., Mahalingasivam, Viyaasan, Parker, Edward P. K., Tomlinson, Laurie A., Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Goldacre, Ben, Walker, Alex J., MacKenna, Brian“…Background: The coronavirus disease 2019 (COVID-19) vaccination programme in England was extended to include all adolescents and children by April 2022. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
18por Schultze, Anna, Nightingale, Emily, Evans, David, Hulme, William, Rosello, Alicia, Bates, Chris, Cockburn, Jonathan, MacKenna, Brian, Curtis, Helen J, Morton, Caroline E, Croker, Richard, Bacon, Seb, McDonald, Helen I, Rentsch, Christopher T, Bhaskaran, Krishnan, Mathur, Rohini, Tomlinson, Laurie A, Williamson, Elizabeth J, Forbes, Harriet, Tazare, John, Grint, Daniel, Walker, Alex J, Inglesby, Peter, DeVito, Nicholas J, Mehrkar, Amir, Hickman, George, Davy, Simon, Ward, Tom, Fisher, Louis, Green, Amelia CA, Wing, Kevin, Wong, Angel YS, McManus, Robert, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen JW, Douglas, Ian J, Smeeth, Liam, Eggo, Rosalind M, Goldacre, Ben, Leon, David A“…METHODS: On behalf of NHS England we used OpenSAFELY-TPP to calculate monthly age-standardised risks of death due to all causes and COVID-19 among adults aged >=65 years between 1/2/2019 and 31/03/2021. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
19por Zhong, Xiaomin, Pate, Alexander, Yang, Ya-Ting, Fahmi, Ali, Ashcroft, Darren M., Goldacre, Ben, MacKenna, Brian, Mehrkar, Amir, Bacon, Sebastian CJ., Massey, Jon, Fisher, Louis, Inglesby, Peter, Hand, Kieran, van Staa, Tjeerd, Palin, Victoria“…METHODS: With the approval of NHS England, we used the OpenSAFELY platform to access the TPP SystmOne electronic health record (EHR) system in primary care and selected patients prescribed antibiotics from 2019 to 2021. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
20por Fisher, Louis, Hopcroft, Lisa EM, Rodgers, Sarah, Barrett, James, Oliver, Kerry, Avery, Anthony J, Evans, Dai, Curtis, Helen, Croker, Richard, Macdonald, Orla, Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian, Davy, Simon, Dillingham, Iain, Evans, David, Hickman, George, Inglesby, Peter, Morton, Caroline E, Smith, Becky, Ward, Tom, Hulme, William, Green, Amelia, Massey, Jon, Walker, Alex J, Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, O’Hanlon, Shaun, Eavis, Alex, Jarvis, Richard, Avramov, Dima, Griffiths, Paul, Fowles, Aaron, Parkes, Nasreen, Goldacre, Ben, MacKenna, Brian“…Potentially hazardous prescribing was largely unaffected by the covid-19 pandemic in primary care health records in England.…”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto