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1por Lawn, Stephen D, Meintjes, Graeme, McIlleron, Helen, Harries, Anthony D, Wood, Robin“…Outcomes of rifampicin-based TB treatment are greatly enhanced by concurrent co-trimoxazole prophylaxis and antiretroviral therapy (ART). ART reduces mortality across a spectrum of CD4 counts and randomized controlled trials have defined the optimum time to start ART. …”
Publicado 2013
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2por Longley, Nicky, Jarvis, Joseph Nicholas, Meintjes, Graeme, Boulle, Andrew, Cross, Anna, Kelly, Nicola, Govender, Nelesh P., Bekker, Linda-Gail, Wood, Robin, Harrison, Thomas S.“…Patients were started on ART between 2 and 4 weeks and followed up for 1 year. …”
Publicado 2016
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3por Scriven, James E., Rhein, Joshua, Hullsiek, Katherine Huppler, von Hohenberg, Maximilian, Linder, Grace, Rolfes, Melissa A., Williams, Darlisha A., Taseera, Kabanda, Meya, David B., Meintjes, Graeme, Boulware, David R.“…Earlier antiretroviral therapy (ART) initiation in cryptococcal meningitis resulted in higher mortality compared with deferred ART initiation (1–2 weeks vs 5 weeks postmeningitis diagnosis). …”
Publicado 2015
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4por Daniels, Johnny Flippie, Khogali, Mohammed, Mohr, Erika, Cox, Vivian, Moyo, Sizulu, Edginton, Mary, Hinderaker, Sven Gudmund, Meintjes, Graeme, Hughes, Jennifer, De Azevedo, Virginia, van Cutsem, Gilles, Cox, Helen Suzanne“…OBJECTIVE: To describe time to antiretroviral treatment (ART) initiation among HIV-infected RR-TB patients initiating RR-TB treatment and to assess the association between time to ART initiation and treatment outcomes. …”
Publicado 2015
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5por Stek, Cari, Schutz, Charlotte, Blumenthal, Lisette, Thienemann, Friedrich, Buyze, Jozefien, Nöstlinger, Christiana, Ravinetto, Raffaella, Wouters, Edwin, Colebunders, Robert, Maartens, Gary, Wilkinson, Robert J, Lynen, Lutgarde, Meintjes, Graeme“…BACKGROUND: Early antiretroviral therapy (ART) initiation in patients diagnosed with HIV-associated tuberculosis (TB) reduces mortality among those with the lowest CD4 counts. …”
Publicado 2016
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6por Pepper, Dominique J., Marais, Suzaan, Wilkinson, Robert J., Bhaijee, Feriyl, De Azevedo, Virginia, Meintjes, Graeme“…The initiation of antiretroviral therapy (ART) during TB therapy significantly improves survival, however it is not known which barriers prevent eligible TB patients from initiating life-saving ART. …”
Publicado 2011
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7por Ford, Nathan, Migone, Chantal, Calmy, Alexandra, Kerschberger, Bernhard, Kanters, Steve, Nsanzimana, Sabin, Mills, Edward J., Meintjes, Graeme, Vitoria, Marco, Doherty, Meg, Shubber, Zara“…BACKGROUND: Recent attention has focused on the question of how quickly antiretroviral therapy (ART) should be started once HIV diagnosis is confirmed. …”
Publicado 2018
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8por Pepper, Dominique J., Marais, Suzaan, Bhaijee, Feriyl, Wilkinson, Robert J., De Azevedo, Virginia, Meintjes, Graeme“…All TB patients lost to follow-up did not initiate ART. Of 85 TB patients in follow-up, 62 (73%) initiated ART 56 days after TB diagnosis (median, IQR 33–77 days) and 31 days after initial assessment at an ART clinic (median, IQR: 18–55 days). …”
Publicado 2012
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9por Osler, Meg, Hilderbrand, Katherine, Goemaere, Eric, Ford, Nathan, Smith, Mariette, Meintjes, Graeme, Kruger, James, Govender, Nelesh P, Boulle, Andrew“…BACKGROUND: Antiretroviral treatment (ART) has been massively scaled up to decrease human immunodeficiency virus (HIV)–related morbidity, mortality, and HIV transmission. …”
Publicado 2018
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10por Meintjes, Graeme, Black, John, Conradie, Francesca, Dlamini, Sipho, Maartens, Gary, Manzini, Thandekile C., Mathe, Moeketsi, Moorhouse, Michelle, Moosa, Yunus, Nash, Jennifer, Orrell, Catherine, Venter, Francois, Wilson, Douglas“…The most recent version of the Southern African HIV Clinicians Society’s adult antiretroviral therapy (ART) guidelines was published in December 2014. …”
Publicado 2015
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11Antiretroviral Treatment Outcomes amongst Older Adults in a Large Multicentre Cohort in South Africa“…INTRODUCTION: Increasing numbers of patients are starting antiretroviral treatment (ART) at advanced age or reaching advanced age while on ART. …”
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12por Kaplan, Samantha R., Oosthuizen, Christa, Stinson, Kathryn, Little, Francesca, Euvrard, Jonathan, Schomaker, Michael, Osler, Meg, Hilderbrand, Katherine, Boulle, Andrew, Meintjes, Graeme“…METHODS AND FINDINGS: We conducted a retrospective cohort study of all patients ≥10 years of age who visited 1 of the 13 Khayelitsha ART clinics from 2013–2014 regardless of the date they initiated ART. …”
Publicado 2017
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13por Conesa-Botella, Anali, Meintjes, Graeme, Coussens, Anna K., van der Plas, Helen, Goliath, Rene, Schutz, Charlotte, Moreno-Reyes, Rodrigo, Mehta, Meera, Martineau, Adrian R., Wilkinson, Robert J., Colebunders, Robert, Wilkinson, Katalin A.“…Plasma from 39 TB-IRIS and 42 non-IRIS patients was collected during a prospective study of HIV-associated tuberculosis patients starting ART. In total, 26% of patients received corticosteroid (CTC) therapy pre-ART for severe tuberculosis. …”
Publicado 2012
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14por Meintjes, Graeme, Dunn, Liezl, Coetsee, Marla, Hislop, Michael, Leisegang, Rory, Regensberg, Leon, Maartens, Gary“…BACKGROUND: An increasing number of patients in Africa are experiencing virologic failure on second-line antiretroviral therapy (ART) and those who develop resistance to protease inhibitors (PI) will require third-line ART, but no data on the outcomes of third-line are available from the region. …”
Publicado 2015
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15por Marais, Suzaan, Meintjes, Graeme, Lesosky, Maia, Wilkinson, Katalin A., Wilkinson, Robert J.“…METHODS: A prospective study of HIV-1-infected adults who presented with either TBM [antiretroviral therapy (ART)-naive] or cryptococcal meningitis (regardless of ART prescription). …”
Publicado 2016
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16por Marais, Suzaan, Meintjes, Graeme, Pepper, Dominique J., Dodd, Lori E., Schutz, Charlotte, Ismail, Zahiera, Wilkinson, Katalin A., Wilkinson, Robert J.“…Tuberculosis immune reconstitution inflammatory syndrome (IRIS) is a common cause of deterioration in human immunodeficiency virus (HIV)–infected patients receiving tuberculosis treatment after starting antiretroviral therapy (ART). Potentially life-threatening neurological involvement occurs frequently and has been suggested as a reason to defer ART. …”
Publicado 2013
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17por Peterson, Tess E., Baker, Jason V., Wong, Lye‐Yeng, Rupert, Adam, Ntusi, Ntobeko A. B., Esmail, Hanif, Wilkinson, Robert, Sereti, Irini, Meintjes, Graeme, Ntsekhe, Mpiko, Thienemann, Friedrich“…AIMS: Efforts to improve access to antiretroviral therapy (ART) have shifted morbidity and mortality among persons living with HIV (PLWH) from AIDS to non‐communicable diseases, such as cardiovascular disease (CVD). …”
Publicado 2020
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18por Mbandi, Stanley Kimbung, Painter, Hannah, Penn‐Nicholson, Adam, Toefy, Asma, Erasmus, Mzwandile, Hanekom, Willem A., Scriba, Thomas J., Lai, Rachel P.J., Marais, Suzaan, Fletcher, Helen A., Meintjes, Graeme, Wilkinson, Robert J., Cotton, Mark F., Pahwa, Savita, Cameron, Mark J., Nemes, Elisa“…Immune reconstitution inflammatory syndrome (IRIS) can be a complication of antiretroviral therapy (ART) in patients with advanced HIV, but its pathogenesis is uncertain. …”
Publicado 2022
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19por Cohe, Karen, Stewart, Annemie, Kengne, Andre P., Leisegang, Rory, Coetsee, Marla, Maharaj, Shavani, Dunn, Liezl, Hislop, Michael, van Zyl, Gert, Meintjes, Graeme, Maartens, Gary“…SETTING: A private sector ART cohort, South Africa. METHODS: We identified adults with virologic failure on ritonavirboosted lopinavir/atazanavir-based ART and GART. …”
Publicado 2019
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20“…Access to antiretroviral therapy (ART) is improving worldwide. Immune reconstitution inflammatory syndrome (IRIS) is a common complication of ART initiation. …”
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