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    Acute Neurologic Illness of Unknown Etiology in Children — Colorado, August–September 2014
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    “…During August 8, 2014–October 14, 2014, a total of 11 children with acute flaccid myelitis and distinctive neuroimaging changes were identified near Denver, Colorado, USA. A respiratory prodrome was experienced by 10, and nasopharyngeal specimens were positive for enterovirus D68 (EV-D68) for 4. …”
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    Enterovirus D68 Infection in Children with Acute Flaccid Myelitis, Colorado, USA, 2014
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    Notes from the Field: Enterovirus A71 Neurologic Disease in Children — Colorado, 2018
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    “…BACKGROUND: In May 2018, an outbreak of enterovirus A71 (EV-A71) neurologic disease was detected at Children’s Hospital Colorado (CHCO) prompting a public health investigation. …”
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    LB8. Outbreak of Enterovirus A71 Neurologic Disease in Children—Colorado, 2018
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    Duration of Enterovirus D68 RNA Shedding in the Upper Respiratory Tract and Transmission among Household Contacts, Colorado, USA
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    “…METHODS: EV-associated AFM was defined as any child presenting to Children’s Hospital Colorado in 2013–2018 who met the Council of State and Territorial Epidemiologists definition for confirmed AFM (flaccid limb weakness with longitudinal gray-matter-predominant spinal cord lesion on MRI) and had EV-A71 or EV-D68 identified in any biologic specimen (cerebrospinal fluid [CSF], nasopharyngeal [NP], oropharyngeal [OP], rectal) by VP1-specific RT-PCR and sequencing. …”
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    1889. Clinical Features Distinguishing Enterovirus A71 and Enterovirus D68-Associated Acute Flaccid Myelitis in Colorado, 2013–2018
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    “…METHODS: In 2010, Children’s Hospital Colorado instituted electronic medical record (EMR) decision support to recommend collection of 2 blood cultures before administration of antibiotics for suspected SBI. …”
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    Two Blood Cultures With Age-Appropriate Volume Enhance Suspected Sepsis Decision-Making
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    “…METHODS: We conducted a retrospective cohort/case control study of children with NMI at Children’s Hospital Colorado from Dec 2016-Apr 2017. We reviewed the medical records to identify children with NMI, and assessed clinical characteristics and outcomes. …”
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    Neurological Manifestations of Hospitalized Children with Influenza During the 2016–2017 Season
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    “…STUDY DESIGN: Respiratory specimens from hospitalized children submitted between January 1, 2009 and December 31, 2009 to Children's Hospital Colorado Virology Laboratory in Aurora, CO were tested by a commercial multiplex PCR for 16 respiratory viruses and subtypes. …”
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    Rhino/enteroviruses in hospitalized children: A comparison to influenza viruses
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    “…METHODS: We retrospectively compared CSF testing and acyclovir use in the pre-MEP era January 1, 2007–January 22, 2017 to post-implementation era of MEP January 23, 2017–December 31, 2017 amongst children >60 days with a CSF specimen sent to the Children’s Hospital Colorado microbiology laboratory. HSV singleplex PCR testing was available in both the pre-MEP and MEP eras. …”
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    652. Impact of FilmArray Meningitis Encephalitis Panel on HSV Testing and Acyclovir Use in Children Beyond the Neonatal Period
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    “…Table 1: FilmArray Meningitis Encephalitis Panel Test Characteristics [Image: see text] METHODS: A pre-post quasi-experimental cohort study to investigate the impact of implementing MEP using a rapid CSF diagnostic stewardship program was conducted at Children’s Hospital Colorado (CHCO). MEP was implemented with EMR indication selection to guide testing to children meeting approved use criteria: i. infants < 2mo, ii. immunocompromised, iii. encephalitis, iv. > 5 WBCs in CSF. …”
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    1019. Clinical Impact of a Rapid Cerebrospinal Fluid Diagnostic Stewardship Program for Suspected Central Nervous System Infections in Children
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