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  1. 1
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    The Need for Predictive, Prognostic, Objective and Complementary Blood-Based Biomarkers in Osteoarthritis (OA)
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    por Mobasheri, Ali, Henrotin, Yves
    Publicado 2015
    “…Arthritic diseases are a major cause of disability and morbidity, and cause an enormous burden for health and social care systems globally. Osteoarthritis (OA) is the most common form of arthritis. The key risk factors for the development of OA are age, obesity, joint trauma or instability. …”
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    Biomarkers of (osteo)arthritis
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    “…Since the role of SDF-1 in OA has not been explored, this study aimed to examine the effect of SDF-1 on NLRP3 inflammasome and pyroptosis in synoviocytes from OA joints. …”
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    Exogenous stromal cell-derived factor-1 (SDF-1) suppresses the NLRP3 inflammasome and inhibits pyroptosis in synoviocytes from osteoarthritic joints via activation of the AMPK signaling pathway
  4. 4
    “…Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide endowed with a range of trophic effects in several cell types; including chondrocytes. However; its role in OA has not been studied. To address this issue, we investigated whether PACAP expression is affected in OA cartilage obtained from experimentally-induced OA rat models, and then studied the effects of PACAP in isolated chondrocytes exposed to IL-1β in vitro to mimic the inflammatory milieu of OA cartilage. …”
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    Ameliorative Effects of PACAP against Cartilage Degeneration. Morphological, Immunohistochemical and Biochemical Evidence from in Vivo and in Vitro Models of Rat Osteoarthritis
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    “…As current treatment options in OA are very limited, OA patients would benefit greatly from some ability to self-manage their condition. …”
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    What is the evidence for a role for diet and nutrition in osteoarthritis?
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    “…Cell death with morphological and molecular features of apoptosis has been detected in osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the pathogenesis of OA. …”
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    Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis
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    “…Osteoarthritis (OA) is a degenerative disease of the articular cartilage, resulting in pain and total joint disability. …”
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    A correlation between intestinal microbiota dysbiosis and osteoarthritis
  8. 8
    “…Arterial hypertension is a common comorbidity in OA patients, and antihypertensive drugs, such as nifedipine (NIF), may affect the course of OA progression. …”
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    Evaluation of Cartilage Integrity Following Administration of Oral and Intraarticular Nifedipine in a Murine Model of Osteoarthritis
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    “…Osteoarthritis (OA) is the most common form of musculoskeletal disease with significant healthcare costs and unmet needs in terms of early diagnosis and treatment. …”
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    The future of deep phenotyping in osteoarthritis: How can high throughput omics technologies advance our understanding of the cellular and molecular taxonomy of the disease?
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    “…Exposure to high glucose (30 mM) for 18 or 48 hours decreased those parameters in normal but not in OA chondrocytes. GLUT-1 mRNA levels were unaffected by high glucose, either in normal or OA chondrocytes. …”
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    Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage
  11. 11
    “…In this study, we developed a gray level co‐occurrence matrix‐based 3D texture analysis method for dual‐echo steady‐state (DESS) magnetic resonance (MR) images to be used for knee cartilage analysis in osteoarthritis (OA) studies and use it to study changes in articular cartilage between different subpopulations based on their rate of progression into radiographically confirmed OA. …”
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    Predicting osteoarthritis onset and progression with 3D texture analysis of cartilage MRI DESS: 6‐Year data from osteoarthritis initiative
  12. 12
    “…OA represents one of the most common causes of physical disability in the world. …”
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    Post-operative rehabilitation and nutrition in osteoarthritis
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    “…Recent research in the field of osteoarthritis (OA) has focused on understanding the underlying molecular and clinical phenotypes of the disease. …”
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    Recent advances in understanding the phenotypes of osteoarthritis
  14. 14
    “…Osteoarthritis (OA) is the most common form of arthritis, characterized by cartilage destruction, pain and inflammation in the joints. …”
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    TissueGene-C promotes an anti-inflammatory micro-environment in a rat monoiodoacetate model of osteoarthritis via polarization of M2 macrophages leading to pain relief and structural improvement
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    “…Osteoarthritis (OA) is a growing public health problem across the globe, affecting more than half of the over 65 population. …”
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    Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression
  16. 16
    “…OBJECTIVES: Osteoarthritis (OA) patients with a neuropathic pain (NP) component may represent a specific phenotype. …”
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    Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort: prevalence and phenotyping
  17. 17
    por Mobasheri, Ali
    Publicado 2011
    “…Aging is a major contributor to musculoskeletal degeneration and the development of osteoarthritis (OA). OA is a degenerative disease that involves structural changes to joint tissues including synovial inflammation, catabolic destruction of articular cartilage and alterations in subchondral bone. …”
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    Applications of Proteomics to Osteoarthritis, a Musculoskeletal Disease Characterized by Aging
  18. 18
    “…Knee osteoarthritis (OA) is one of the most prevalent chronic conditions affecting the adult population. …”
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    Molecular-Morphological Relationships of the Scaffold Protein FKBP51 and Inflammatory Processes in Knee Osteoarthritis
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    “…An imaging modality for DMOAD trials should be able to depict soft tissue and osseous pathologies that are relevant to OA disease progression and clinical manifestations of OA. …”
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    Strategic application of imaging in DMOAD clinical trials: focus on eligibility, drug delivery, and semiquantitative assessment of structural progression
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    “…Given the significant potential of clusterin as a biomarker of osteoarthritis (OA), a more detailed analysis of its complex network in an inflammatory environment, specifically in the context of OA, is required. …”
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    The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis
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