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1por Ali, Talib Hassan, Pisanti, Simona, Ciaglia, Elena, Mortarini, Roberta, Anichini, Andrea, Garofalo, Cinzia, Tallerico, Rossana, Santinami, Mario, Gulletta, Elio, Ietto, Caterina, Galgani, Mario, Matarese, Giuseppe, Bifulco, Maurizio, Ferrone, Soldano, Colucci, Francesco, Moretta, Alessandro, Kärre, Klas, Carbone, Ennio“…We show an expansion of CD56(dim)CD57(dim)CD69+CCR7+KIR+ NK cells in TILN. TILN NK cells display robust cytotoxic activity against autologous melanoma cells. …”
Publicado 2014
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2por Pesce, Silvia, Squillario, Margherita, Greppi, Marco, Loiacono, Fabrizio, Moretta, Lorenzo, Moretta, Alessandro, Sivori, Simona, Castagnola, Patrizio, Barla, Annalisa, Candiani, Simona, Marcenaro, Emanuela“…In particular, the two main NK cell subsets are represented by the CD56(bright)/CD16(−/dim) and the CD56(dim)/CD16(bright) NK cells. Experimental evidences indicate that CD56(bright) and CD56(dim) NK cells represent different maturative stages of the NK cell developmental pathway. …”
Publicado 2018
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3por Della Chiesa, Mariella, Pesce, Silvia, Muccio, Letizia, Carlomagno, Simona, Sivori, Simona, Moretta, Alessandro, Marcenaro, Emanuela“…Human NK cells are distinguished into CD56(bright)CD16(−) cells and CD56(dim)CD16(+) cells. These two subsets are conventionally associated with differential functional outcomes and are heterogeneous with respect to the expression of KIR and CD94/NKG2 heterodimers that represent the two major types of HLA-class I-specific receptors. …”
Publicado 2016
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4“…Only recently, a key role for CCR7 in promoting CD56(dim) NK cell migration toward lymphoid tissues has been described. …”
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5por Muccio, Letizia, Falco, Michela, Bertaina, Alice, Locatelli, Franco, Frassoni, Francesco, Sivori, Simona, Moretta, Lorenzo, Moretta, Alessandro, Della Chiesa, Mariella“…This feature characterized only a minor fraction of the HCMV-imprinted NKG2C(+)CD57(+) CD56(dim) NK cell subset, while it was detectable in higher proportions of CD57(+) NK cells lacking NKG2C. …”
Publicado 2018
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6por Gondois-Rey, Françoise, Chéret, Antoine, Granjeaud, Samuel, Mallet, Françoise, Bidaut, Ghislain, Lécuroux, Camille, Ploquin, Mickaël, Müller-Trutwin, Michaela, Rouzioux, Christine, Avettand-Fenoël, Véronique, Moretta, Alessandro, Pialoux, Gilles, Goujard, Cécile, Meyer, Laurence, Olive, Daniel“…NK(bright) NKG2C(+) progenitor, NK(dim) NKG2C(+) effector and NK(dim) NKG2C(+)CD57(+) memory-like populations were identified. …”
Publicado 2017
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7por Mariotti, Francesca R., Petrini, Stefania, Ingegnere, Tiziano, Tumino, Nicola, Besi, Francesca, Scordamaglia, Francesca, Munari, Enrico, Pesce, Silvia, Marcenaro, Emanuela, Moretta, Alessandro, Vacca, Paola, Moretta, Lorenzo“…PD-1 mRNA and protein were higher in CD56(dim) than in CD56(bright) NK cells. Confocal microscopy analyses revealed that PD-1 protein is present in virtually all NK cells analyzed. …”
Publicado 2018
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8por Zimmer, Jacques, Bausinger, Huguette, Andrès, Emmanuel, Donato, Lionel, Hanau, Daniel, Hentges, François, Moretta, Alessandro, de la Salle, Henri“…The patients also displayed a higher percentage of CD56(dim)CD16(−) NK cells than controls. Interestingly, this unusual NK cell subtype distribution was not found in the two asymptomatic TAP-deficient cases, but was instead present in several of the other patients. …”
Publicado 2007
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