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    “…In particular, the two main NK cell subsets are represented by the CD56(bright)/CD16(−/dim) and the CD56(dim)/CD16(bright) NK cells. Experimental evidences indicate that CD56(bright) and CD56(dim) NK cells represent different maturative stages of the NK cell developmental pathway. …”
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    “…Human NK cells are distinguished into CD56(bright)CD16(−) cells and CD56(dim)CD16(+) cells. These two subsets are conventionally associated with differential functional outcomes and are heterogeneous with respect to the expression of KIR and CD94/NKG2 heterodimers that represent the two major types of HLA-class I-specific receptors. …”
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    “…Only recently, a key role for CCR7 in promoting CD56(dim) NK cell migration toward lymphoid tissues has been described. …”
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    “…This feature characterized only a minor fraction of the HCMV-imprinted NKG2C(+)CD57(+) CD56(dim) NK cell subset, while it was detectable in higher proportions of CD57(+) NK cells lacking NKG2C. …”
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    “…PD-1 mRNA and protein were higher in CD56(dim) than in CD56(bright) NK cells. Confocal microscopy analyses revealed that PD-1 protein is present in virtually all NK cells analyzed. …”
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    “…The patients also displayed a higher percentage of CD56(dim)CD16(−) NK cells than controls. Interestingly, this unusual NK cell subtype distribution was not found in the two asymptomatic TAP-deficient cases, but was instead present in several of the other patients. …”
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