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1por Chambers, James K., Tokuda, Takahiko, Uchida, Kazuyuki, Ishii, Ryotaro, Tatebe, Harutsugu, Takahashi, Erika, Tomiyama, Takami, Une, Yumi, Nakayama, Hiroyuki“…Although many animal species develop senile plaques (SP) composed of amyloid-β (Aβ) proteins that are identical to those found in humans, none of them exhibit neurofibrillary tangles (NFT) and subsequent neurodegeneration, which are integral parts of the pathology of AD. …”
Publicado 2015
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2por Chambers, James K., Uchida, Kazuyuki, Harada, Tomoyuki, Tsuboi, Masaya, Sato, Masumi, Kubo, Masahito, Kawaguchi, Hiroaki, Miyoshi, Noriaki, Tsujimoto, Hajime, Nakayama, Hiroyuki“…Sequence analysis of the amyloid precursor protein revealed an amino acid substitution at the 7th residue of the Aβ peptide. In a comparison with other mammalian animals that do develop argyrophilic senile plaques, we concluded that the alternative Aβ amino acid sequence displayed by leopard cats is likely to be related to its distinctive deposition pattern. …”
Publicado 2012
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3por Takaichi, Yuta, Chambers, James K., Takahashi, Kei, Soeda, Yoshiyuki, Koike, Riki, Katsumata, Etsuko, Kita, Chiaki, Matsuda, Fuko, Haritani, Makoto, Takashima, Akihiko, Nakayama, Hiroyuki, Uchida, Kazuyuki“…The AD-related pathology has been reported in several non-human animals, and most animals develop only the Aβ or tau pathology. …”
Publicado 2021
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