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1por Chu-Tan, Joshua A., Cioanca, Adrian V., Wooff, Yvette, Kirkby, Max, Ellis, Marissa, Gulati, Pranay, Karl, Tim, Boatright, Jeffrey H., Bales, Katie, Nickerson, John, Natoli, Riccardo“…In response to voluntary exercise, inflammatory and extracellular matrix integrity pathways were significantly modulated, with the gene expression profile of exercised mice more closely trending towards that of a healthy dim-reared retina. Conclusion: We suggest that voluntary exercise may mediate retinal protection by influencing key pathways involved in regulating retinal health and shifting the transcriptomic profile to a healthy phenotype.…”
Publicado 2023
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2por Natoli, Riccardo, Zhu, Yuan, Valter, Krisztina, Bisti, Silvia, Eells, Janis, Stone, Jonathan“…METHODS: We used a previously published assay of photoreceptor damage, in which albino Sprague Dawley rats raised in dim cyclic illumination (12 h 5 lux, 12 h darkness) were challenged by 24 h exposure to bright (1,000 lux) light. …”
Publicado 2010
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3por Rutar, Matt, Natoli, Riccardo, Albarracin, Rizalyn, Valter, Krisztina, Provis, Jan“…Animals were exposed to white light (1,000 lux) for 24 h, after which animals were kept in dim light (5 lux) for 7 days. Expression of complement genes was assessed by quantitative polymerase chain reaction (qPCR), and immunohistochemistry. …”
Publicado 2012
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4por Aggio-Bruce, Riemke, Chu-Tan, Joshua A., Wooff, Yvette, Cioanca, Adrian V., Schumann, Ulrike, Natoli, Riccardo“…Inhibition of miR-155 showed increased function from negative controls and a less pathological pattern of IBA1(+) cell localisation and morphology at 5 days photo-oxidative damage. While neither dim-reared nor damaged miR-155 KO animals showed retinal histological difference from controls, following photo-oxidative damage, miR-155 KO mice showed increased a-wave relative to controls. …”
Publicado 2020
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5“…METHODS: Young adult C57BL/6J mice raised in dim cyclic illumination (12 h at 5 lx and 12 h in darkness) were exposed to hyperoxia (75% oxygen for two weeks). …”
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6por Wooff, Yvette, Cioanca, Adrian V., Wills, Elly, Chu-Tan, Joshua A., Sekar, Rakshanya, Natoli, Riccardo“…METHODS: C57BL/6J mice were exposed to 1, 3, 6, 12, or 24h photo-oxidative damage (PD) using 100k lux bright white light. Mice were compared to dim-reared (DR) healthy controls as well as mice which had undergone long periods of photo-oxidative damage (3d and 5d-PD) as known timepoints for inducing late-stage retinal degeneration pathologies. …”
Publicado 2023
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