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1“…We finally integrate this plasticity into a new model of GCC pathogenesis, allowing for an alternative view on the dynamics of GCC development and progression.…”
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2por Nettersheim, Daniel, Jostes, Sina, Fabry, Martin, Honecker, Friedemann, Schumacher, Valerie, Kirfel, Jutta, Kristiansen, Glen, Schorle, Hubert“…In Western countries, the incidence of testicular germ cell cancers (GCC) is steadily rising over the last decades. Mostly, men between 20 and 40 years of age are affected. …”
Publicado 2016
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3por Nettersheim, Daniel, Heimsoeth, Alena, Jostes, Sina, Schneider, Simon, Fellermeyer, Martin, Hofmann, Andrea, Schorle, Hubert“…Type II germ cell cancers (GCC) are divided into seminomas, which are highly similar to primordial germ cells and embryonal carcinomas (EC), often described as malignant counterparts to embryonic stem cells. …”
Publicado 2016
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4por Nettersheim, Daniel, Jostes, Sina, Sharma, Rakesh, Schneider, Simon, Hofmann, Andrea, Ferreira, Humberto J., Hoffmann, Per, Kristiansen, Glen, Esteller, Manel B., Schorle, Hubert“…Type II germ cell cancers (GCC) can be subdivided into seminomas and non-seminomas. …”
Publicado 2015
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5por Nettersheim, Daniel, Arndt, Isabell, Sharma, Rakesh, Riesenberg, Stefanie, Jostes, Sina, Schneider, Simon, Hölzel, Michael, Kristiansen, Glen, Schorle, Hubert“…METHODS: We analysed the molecular function of the CTA PRAME in primordial germ cells (PGC) and testicular germ cell cancers (GCC). GCCs arise from a common precursor lesion termed germ cell neoplasia in situ (GCNIS), which itself is thought to originate from a defective PGC. …”
Publicado 2016
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