“…Identifying climate drivers is essential to understand and predict epidemics of mosquito-borne infections whose population dynamics typically exhibit seasonality and multiannual cycles. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The influence of transmission intensity on the evolution of drug resistance has been addressed in theoretical studies from a population genetics' perspective; less is known however on how epidemiological dynamics at the population level modulates this influence. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The model explicitly considers the extensive diversity of multi-copy genes that undergo antigenic variation via sequential, mutually exclusive expression. It tracks the dynamics of all unique var repertoires in a population of hosts, and shows that even under high levels of sexual recombination, strain competition mediated through cross-immunity structures the parasite population into a subset of coexisting dominant repertoires of var genes whose degree of antigenic overlap depends on transmission intensity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Models that account for climate factors, socioeconomic level and population size show the highest predictive skill. A comparison to the transmission dynamics of falciparum malaria reinforces the conclusion that the spatio-temporal patterns of risk are strongly driven by extrinsic factors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…As a result, high (asymptomatic) prevalence is observed despite high immunity in local populations under high-transmission settings. The vast diversity of “strains” and genes encoding this variation challenges the application of established models for the population dynamics of such infectious diseases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: Selective dynamics induce a canalized evolutionary trajectory, in which the evolutionary fate of the influenza population is surprisingly repeatable. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Influenza A (H3N2) offers a well-studied, yet not fully understood, disease in terms of the interactions between pathogen population dynamics, epidemiology and genetics. A major open question is why the virus population is globally dominated by a single and very recently diverged (2–8 years) lineage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Through analysis of simulated populations and sequence data from influenza A (H3N2) and measles virus, we show how phylogenetic and population genetic techniques can be used to assess the strength and temporal pattern of adaptive evolution. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Arthropod vectors experience a complex suite of environmental factors that affect fitness, population growth and species interactions across multiple spatial and temporal scales. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…During this 17 year period, malaria dynamics underwent a major regime shift around May 1991, following the introduction of bed nets as a control strategy in the country. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This relationship implies that the dynamics of global densities can be written simply as a function of those densities alone without invoking pairs (or higher order moments). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A better understanding of the connection between vector recruitment and host density is needed to address the population dynamics of mosquito-transmitted infections in urban landscapes.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We extend an analytical approach to determine the number of ‘skip’ years preceding re-emergence for diseases with continuous seasonal transmission, population growth and under-reporting. Re-emergence times are shown to be highly sensitive to small changes in low R(0) (secondary cases produced from a primary infection in a fully susceptible population). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Comparison to neutral models that retain parasite population dynamics but lack competition reveals that the selection imposed by host immunity promotes the persistence of these modules. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although H3N2 incidence is highly seasonal, how such seasonality contributes to global phylogeographic migration dynamics has not yet been established. In this study, we incorporate time-varying migration rates in a Bayesian MCMC framework. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Strain theory postulates that pathogen populations can be structured into distinct nonoverlapping strains by frequency‐dependent selection in response to intraspecific competition for host immune space. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso