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1por Huntington, Susie, Thorne, Claire, Anderson, Jane, Newell, Marie-Louise, Taylor, Graham P, Pillay, Deenan, Hill, Teresa, Tookey, Pat, Sabin, Caroline“…CONCLUSIONS: In this setting, antenatal ZDVm exposure did not adversely impact on outcomes once ART was initiated for the woman’s health.…”
Publicado 2014
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2por Huntington, Susie, Thorne, Claire, Anderson, Jane, Newell, Marie-Louise, Taylor, Graham, Pillay, Deenan, Hill, Teresa, Tookey, Pat, Sabin, Caroline“…INTRODUCTION: High rates of hepatotoxicity have been observed among HIV-positive pregnant women using antiretroviral therapy (ART). However, the extent to which pregnancy affects the risk of ART-induced hepatotoxicity is unclear since studies in this area have generated conflicting results. …”
Publicado 2014
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3por Feigl, Andrea B., Bloom, David E., Danaei, Goodarz, Pillay, Deenan, Salomon, Joshua A., Tanser, Frank, Bärnighausen, Till W.“…We modeled change in BMI and BP longitudinally in HIV(-) individuals (n = 315), seroconverters (n = 32), HIV(+) patients not on ART (HIV(+)ART(−); n = 52), HIV(+) patients on ART for 0–<2 years as of 2010 (HIV(+)ART(0–<2 yrs); n = 18), patients on ART for 2–5 years (HIV(+)ART(2–5yrs); n = 44), and a subgroup with unknown HIV status (n = 44). …”
Publicado 2016
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4por Barnabas, Ruanne V, Szpiro, Adam A, van Rooyen, Heidi, Asiimwe, Stephen, Pillay, Deenan, Ware, Norma C, Schaafsma, Torin T, Krows, Meighan L, van Heerden, Alastair, Joseph, Philip, Shahmanesh, Maryam, Wyatt, Monique A, Sausi, Kombi, Turyamureeba, Bosco, Sithole, Nsika, Morrison, Susan, Shapiro, Adrienne E, Roberts, D Allen, Thomas, Katherine K, Koole, Olivier, Bershteyn, Anna, Ehrenkranz, Peter, Baeten, Jared M, Celum, Connie“…We aimed to test the effect of community-based ART delivery on viral suppression among people living with HIV not on ART. …”
Publicado 2020
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5por Goodall, Ruth L., Dunn, David T., Nkurunziza, Peter, Mugarura, Lincoln, Pattery, Theresa, Munderi, Paula, Kityo, Cissy, Gilks, Charles, Kaleebu, Pontiano, Pillay, Deenan, Gupta, Ravindra K.“…Background: Lack of viral load monitoring of ART is known to be associated with slower switch from a failing regimen and thereby higher prevalence of MDR HIV-1. …”
Publicado 2017
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6por Dolling, David I., Goodall, Ruth L., Chirara, Michael, Hakim, James, Nkurunziza, Peter, Munderi, Paula, Eram, David, Tumukunde, Dinah, Spyer, Moira J., Gilks, Charles F., Kaleebu, Pontiano, Dunn, David T., Pillay, Deenan“…Patients initiated first-line ART at a median (interquartile range; IQR) age of 37 (32–42) and with a median CD4 cell count of 86 (32–140). …”
Publicado 2017
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7por Derache, Anne, Iwuji, Collins C, Danaviah, Siva, Giandhari, Jennifer, Marcelin, Anne-Geneviève, Calvez, Vincent, de Oliveira, Tulio, Dabis, François, Pillay, Deenan, Gupta, Ravindra K“…METHODS: Within the treatment-as-prevention study in South Africa, we selected participants with available next-generation sequencing (NGS) data for the HIV-1 pol gene at trial entry; they were either ART initiators (n = 1193) or already established on ART (n = 94). …”
Publicado 2019
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8por Iwuji, Collins, McGrath, Nuala, Calmy, Alexandra, Dabis, Francois, Pillay, Deenan, Newell, Marie‐Louise, Baisley, Kathy, Porter, Kholoud“…We investigated whether initiating ART at higher CD4 counts was associated with sub‐optimal adherence (<95%) during the first 12 months of ART. …”
Publicado 2018
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9por Plazy, Melanie, Perriat, Delphine, Gumede, Dumile, Boyer, Sylvie, Pillay, Deenan, Dabis, François, Seeley, Janet, Orne-Gliemann, Joanna“…HCPs also foresaw logistical challenges of universal ART, and were especially concerned about increasing workload and ART shortage. …”
Publicado 2017
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10por Bor, Jacob, Fox, Matthew P., Rosen, Sydney, Venkataramani, Atheendar, Tanser, Frank, Pillay, Deenan, Bärnighausen, Till“…BACKGROUND: Loss to follow-up is high among HIV patients not yet receiving antiretroviral therapy (ART). Clinical trials have demonstrated the clinical efficacy of early ART; however, these trials may miss an important real-world consequence of providing ART at diagnosis: its impact on retention in care. …”
Publicado 2017
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11por Boyer, Sylvie, Iwuji, Collins, Gosset, Andréa, Protopopescu, Camelia, Okesola, Nonhlanhla, Plazy, Mélanie, Spire, Bruno, Orne-Gliemann, Joanna, McGrath, Nuala, Pillay, Deenan, Dabis, François, Larmarange, Joseph“…Prompt uptake of antiretroviral treatment (ART) is essential to ensure the success of universal test and treat (UTT) strategies to prevent HIV transmission in high-prevalence settings. …”
Publicado 2016
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12por Bor, Jacob, Ahmed, Shahira, Fox, Matthew P., Rosen, Sydney, Meyer-Rath, Gesine, Katz, Ingrid T., Tanser, Frank, Pillay, Deenan, Bärnighausen, Till“…BACKGROUND: The World Health Organization recommends initiating antiretroviral therapy (ART) regardless of CD4 count. We assessed the effect of ART eligibility on treatment uptake and simulated the impact of WHO’s recommendations in South Africa. …”
Publicado 2017
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13por Maskew, Mhairi, Bor, Jacob, Hendrickson, Cheryl, MacLeod, William, Bärnighausen, Till, Pillay, Deenan, Sanne, Ian, Carmona, Sergio, Stevens, Wendy, Fox, Matthew P“…METHODS: We developed an algorithm to impute ART start dates based on the date of a patient’s “ART workup”, i.e. the laboratory tests used to determine treatment readiness in national guidelines, and the time from ART workup to initiation based on clinical protocols (21 days). …”
Publicado 2017
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14por Hontelez, Jan A. C., Tanser, Frank C., Naidu, Kevindra K., Pillay, Deenan, Bärnighausen, Till“…BACKGROUND: The effect of the rapid scale-up of vertical antiretroviral treatment (ART) programs for HIV in sub-Saharan Africa on the overall health system is under intense debate. …”
Publicado 2016
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15por Low, Andrea J., Konate, Issouf, Nagot, Nicolas, Weiss, Helen A., Kania, Dramane, Vickerman, Peter, Segondy, Michel, Mabey, David, Pillay, Deenan, Meda, Nicolas, van de Perre, Philippe, Mayaud, Philippe“…BACKGROUND: Antiretroviral therapy (ART) reduces transmission of HIV-1. However, genital HIV-1 can be detected in patients on ART. …”
Publicado 2014
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16por Kluberg, Sheryl A., Fox, Matthew P., LaValley, Michael, Pillay, Deenan, Bärnighausen, Till, Bor, Jacob“…OBJECTIVE: The 2015 WHO recommendation to initiate all HIV patients on antiretroviral therapy (ART) at diagnosis could potentially overextend health systems and crowd out sicker patients, mitigating the policy's impact. …”
Publicado 2018
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17por Geldsetzer, Pascal, Feigl, Andrea B., Tanser, Frank, Gareta, Dickman, Pillay, Deenan, Barnighausen, Till“…METHODS: A household survey was conducted in rural KwaZulu-Natal before ART scale-up (in 2004) and when ART coverage had reached 25% (in 2010). …”
Publicado 2016
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18por Oldenburg, Catherine E., Bärnighausen, Till, Tanser, Frank, Iwuji, Collins C., De Gruttola, Victor, Seage, George R., Mimiaga, Matthew J., Mayer, Kenneth H., Pillay, Deenan, Harling, Guy“…Antiretroviral therapy (ART) was highly efficacious in preventing human immunodeficiency virus (HIV) transmission in stable serodiscordant couples in the HPTN-052 study, a resource-intensive randomized controlled trial with near-perfect ART adherence and mutual HIV status disclosure among all participating couples. …”
Publicado 2016
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19por Siedner, Mark J., Baisley, Kathy, Koole, Olivier, Mpofana, Innocentia, Ording-Jespersen, Gregory, Matthews, Philippa, Herbst, Kobus, Smit, Theresa, Pillay, Deenan“…Rapid diagnostic tests (RDTs) are the mainstay of HIV diagnosis in the developing world but might have poor sensitivity among individuals taking antiretroviral therapy (ART). We leveraged a home-based HIV testing program linked to clinical data to compare the sensitivity of RDTs between individuals using versus not using ART. …”
Publicado 2020
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20por Phillips, Andrew N, Cambiano, Valentina, Nakagawa, Fumiyo, Revill, Paul, Jordan, Michael R, Hallett, Timothy B, Doherty, Meg, De Luca, Andrea, Lundgren, Jens D, Mhangara, Mutsa, Apollo, Tsitsi, Mellors, John, Nichols, Brooke, Parikh, Urvi, Pillay, Deenan, Rinke de Wit, Tobias, Sigaloff, Kim, Havlir, Diane, Kuritzkes, Daniel R, Pozniak, Anton, van de Vijver, David, Vitoria, Marco, Wainberg, Mark A, Raizes, Elliot, Bertagnolio, Silvia“…BACKGROUND: There is concern over increasing prevalence of non-nucleoside reverse-transcriptase inhibitor (NNRTI) resistance in people initiating antiretroviral therapy (ART) in low-income and middle-income countries. …”
Publicado 2017
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