Mostrando 1 - 19 Resultados de 19 Para Buscar '"The Messengers"', tiempo de consulta: 0.85s Limitar resultados
  1. 1
    “…Analogues of the potent Ca(2+) releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. …”
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    ‘Click cyclic ADP-ribose’: a neutral second messenger mimic
  2. 2
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    Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR)
  3. 3
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    A synthetic cyclitol-nucleoside conjugate polyphosphate is a highly potent second messenger mimic
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    Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP(5)
  5. 5
    “…The multifunctional, transmembrane glycoprotein human CD38 catalyses the synthesis of three key Ca(2+)-mobilising messengers, including cyclic adenosine 5′-diphosphate ribose (cADPR), and CD38 knockout studies have revealed the relevance of the related signalling pathways to disease. …”
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    Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5′-diphosphate ribose”
  6. 6
    “…Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-releasing second messenger known to date, but the precise NAADP/Ca(2+) signalling mechanisms are still controversial. …”
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    Small Molecule Antagonists of NAADP-Induced Ca(2+) Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease
  7. 7
    “…[Image: see text] The inositol polyphosphate 5-phosphatase INPP5B hydrolyzes the 5-phosphate group from water- and lipid-soluble signaling messengers. Two synthetic benzene and biphenyl polyphosphates (BzP/BiPhPs), simplified surrogates of inositol phosphates and phospholipid headgroups, were identified by thermodynamic studies as potent INPP5B ligands. …”
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    Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family
  8. 8
    “…Novel 8-substituted base and sugar-modified analogues of the Ca(2+) mobilizing second messenger cyclic adenosine 5′-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational analysis investigated by (1)H NMR spectroscopy revealed that a C2′ endo/syn conformation of the “southern” ribose is crucial for agonist or antagonist activity at the SUH-, but not at the T cell-cADPR receptor.…”
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    Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn “southern” ribose conformation underlies activity at the sea urchin cADPR receptor
  9. 9
    “…[Image: see text] Stable cyclic adenosine 5′-diphosphate ribose (cADPR) analogues are chemical biology tools that can probe the Ca(2+) release mechanism and structure–activity relationships of this emerging potent second messenger. However, analogues with an intact “northern” ribose have been inaccessible due to the difficulty of generating the sensitive N1-ribosyl link. …”
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    Total Synthesis of a Cyclic Adenosine 5′-Diphosphate Ribose Receptor Agonist
  10. 10
    “…Cyclic adenosine 5′-diphosphate ribose (cADPR) is an emerging Ca(2+)-mobilising second messenger. cADPR analogues have been generated as chemical biology tools via both chemo-enzymatic and total synthetic routes. …”
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    Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers
  11. 11
    “…Inositol pyrophosphates (PP-IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. …”
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    Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs
  12. 12
    “…Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-releasing second messenger known to date. Here, we report a new role for NAADP in arrhythmogenic Ca(2+) release in cardiac myocytes evoked by β-adrenergic stimulation. …”
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    Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation
  13. 13
    “…Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the N1-ribosylated, Ca(2+)-mobilizing, second messenger cyclic adenosine 5′-diphosphoribose (cADPR). …”
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    Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship
  14. 14
    “…Cyclic ADP-ribose (cADPR) is a universal calcium messenger molecule that regulates many physiological processes. …”
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    Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase
  15. 15
    “…[Image: see text] Analogues of the Ca(2+)-releasing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [1, Ins(1,4,5)P(3)] are important synthetic targets. …”
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    d-chiro-Inositol Ribophostin: A Highly Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors: Synthesis and Biological Activities
  16. 16
    “…[Image: see text] d-myo-Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are Ca(2+) channels activated by the intracellular messenger inositol 1,4,5-trisphosphate (IP(3), 1). …”
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    Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors
  17. 17
    “…[Image: see text] Chiral sugar derivatives are potential cyclitol surrogates of the Ca(2+)-mobilizing intracellular messenger d-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)]. …”
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    Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P(3) Receptor
  18. 18
    “…Nicotinic acid adenine dinucleotide phosphate represents a newly identified second messenger in T cells involved in antigen receptor-mediated calcium signalling. …”
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    Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system
  19. 19
    “…Few inhibitors exist for CD38, a multifunctional enzyme catalyzing the formation and metabolism of the Ca(2+)-mobilizing second messenger cyclic adenosine 5′-diphosphoribose (cADPR). …”
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    CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template
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