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1por Wittsack, Hans-Jörg, Radke, Karl Ludger, Stabinska, Julia, Ljimani, Alexandra, Müller-Lutz, Anja“…Analysis of chemical exchange saturation transfer (CEST) MRI data requires sophisticated methods to obtain reliable results about metabolites in the tissue under study. …”
Publicado 2023
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2por Abrar, Daniel B., Schleich, Christoph, Radke, Karl Ludger, Frenken, Miriam, Stabinska, Julia, Ljimani, Alexandra, Wittsack, Hans-Jörg, Antoch, Gerald, Bittersohl, Bernd, Hesper, Tobias, Nebelung, Sven, Müller-Lutz, Anja“…OBJECTIVE: To establish and optimize a stable 3 Tesla (T) glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging protocol for assessing the articular cartilage of the tibiotalar joint in healthy volunteers and patients after a sustained injury to the ankle. …”
Publicado 2020
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3por Radke, Karl Ludger, Kamp, Benedikt, Adriaenssens, Vibhu, Stabinska, Julia, Gallinnis, Patrik, Wittsack, Hans-Jörg, Antoch, Gerald, Müller-Lutz, Anja“…Chemical Exchange Saturation Transfer (CEST) magnetic resonance imaging (MRI) provides a novel method for analyzing biomolecule concentrations in tissues without exogenous contrast agents. …”
Publicado 2023
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4por Frenken, Miriam, Nebelung, Sven, Schleich, Christoph, Müller-Lutz, Anja, Radke, Karl Ludger, Kamp, Benedikt, Boschheidgen, Matthias, Wollschläger, Lena, Bittersohl, Bernd, Antoch, Gerald, Konieczny, Markus R., Abrar, Daniel B.“…A total of 18 patients (mean age 57.5 ± 22.5 years) with radiculopathy, 16 age-matched patients with chronic nsLBP and 20 age-matched volunteers underwent standard morphologic and compositional gagCEST MRI on a 3T scanner. In all cohorts, GAG contents of lumbar IVDs were determined using gagCEST MRI. …”
Publicado 2021
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5por Radke, Karl Ludger, Wilms, Lena Marie, Frenken, Miriam, Stabinska, Julia, Knet, Marek, Kamp, Benedikt, Thiel, Thomas Andreas, Filler, Timm Joachim, Nebelung, Sven, Antoch, Gerald, Abrar, Daniel Benjamin, Wittsack, Hans-Jörg, Müller-Lutz, Anja“…The study presented here is the first to introduce a new qCEST method that enables qCEST imaging in systems with multiple proton pools.…”
Publicado 2022
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6por Abrar, Daniel B., Schleich, Christoph, Tsiami, Styliani, Müller-Lutz, Anja, Radke, Karl Ludger, Holthausen, Neela, Frenken, Miriam, Boschheidgen, Matthias, Antoch, Gerald, Mucke, Johanna, Sewerin, Philipp, Braun, Juergen, Nebelung, Sven, Baraliakos, Xenofon“…Kendall-Tau correlation analyses were performed. RESULTS: GagCEST values were significantly lower in AS patients (2.0 ± 1.7%) vs. healthy volunteers (2.4 ± 1.8%), p = 0.001. …”
Publicado 2020
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7por Radke, Karl Ludger, Abrar, Daniel B., Frenken, Miriam, Wilms, Lena Marie, Kamp, Benedikt, Boschheidgen, Matthias, Liebig, Patrick, Ljimani, Alexandra, Filler, Timm Joachim, Antoch, Gerald, Nebelung, Sven, Wittsack, Hans-Jörg, Müller-Lutz, Anja“…Based on in silico, in vitro, in situ, and in vivo evaluations, this study aims to establish and optimize the chemical exchange saturation transfer (CEST) imaging of lactate (Lactate-CEST—LATEST). To this end, we optimized LATEST sequences using Bloch–McConnell simulations for optimal detection of lactate with a clinical 3 T MRI scanner. …”
Publicado 2022
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