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1por Raue, Andreas, Schilling, Marcel, Bachmann, Julie, Matteson, Andrew, Schelke, Max, Kaschek, Daniel, Hug, Sabine, Kreutz, Clemens, Harms, Brian D., Theis, Fabian J., Klingmüller, Ursula, Timmer, Jens“…Due to the high complexity of biological data it is difficult to disentangle cellular processes relying only on intuitive interpretation of measurements. A Systems Biology approach that combines quantitative experimental data with dynamic mathematical modeling promises to yield deeper insights into these processes. …”
Publicado 2013
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2por Sobotta, Svantje, Raue, Andreas, Huang, Xiaoyun, Vanlier, Joep, Jünger, Anja, Bohl, Sebastian, Albrecht, Ute, Hahnel, Maximilian J., Wolf, Stephanie, Mueller, Nikola S., D'Alessandro, Lorenza A., Mueller-Bohl, Stephanie, Boehm, Martin E., Lucarelli, Philippe, Bonefas, Sandra, Damm, Georg, Seehofer, Daniel, Lehmann, Wolf D., Rose-John, Stefan, van der Hoeven, Frank, Gretz, Norbert, Theis, Fabian J., Ehlting, Christian, Bode, Johannes G., Timmer, Jens, Schilling, Marcel, Klingmüller, Ursula“…While different inhibitors of IL-6-induced JAK1-STAT3-signaling have been developed, understanding their precise impact on signaling dynamics requires a systems biology approach. Here we present a mathematical model of IL-6-induced JAK1-STAT3 signaling that quantitatively links physiological IL-6 concentrations to the dynamics of IL-6-induced signal transduction and expression of target genes in hepatocytes. …”
Publicado 2017
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