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1por Shah, Tina, Engmann, Jorgen, Dale, Caroline, Shah, Sonia, White, Jon, Giambartolomei, Claudia, McLachlan, Stela, Zabaneh, Delilah, Cavadino, Alana, Finan, Chris, Wong, Andrew, Amuzu, Antoinette, Ong, Ken, Gaunt, Tom, Holmes, Michael V., Warren, Helen, Davies, Teri-Louise, Drenos, Fotios, Cooper, Jackie, Sofat, Reecha, Caulfield, Mark, Ebrahim, Shah, Lawlor, Debbie A., Talmud, Philippa J., Humphries, Steve E., Power, Christine, Hypponen, Elina, Richards, Marcus, Hardy, Rebecca, Kuh, Diana, Wareham, Nicholas, Ben-Shlomo, Yoav, Day, Ian N., Whincup, Peter, Morris, Richard, Strachan, Mark W. J., Price, Jacqueline, Kumari, Meena, Kivimaki, Mika, Plagnol, Vincent, Dudbridge, Frank, Whittaker, John C., Casas, Juan P., Hingorani, Aroon D.“…Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.…”
Publicado 2013
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2por Shah, Tina, Engmann, Jorgen, Dale, Caroline, Shah, Sonia, White, Jon, Giambartolomei, Claudia, McLachlan, Stela, Zabaneh, Delilah, Cavadino, Alana, Finan, Chris, Wong, Andrew, Amuzu, Antoinette, Ong, Ken, Gaunt, Tom, Holmes, Michael V., Warren, Helen, Davies, Teri-Louise, Drenos, Fotios, Cooper, Jackie, Sofat, Reecha, Caulfield, Mark, Ebrahim, Shah, Lawlor, Debbie A., Talmud, Philippa J., Humphries, Steve E., Power, Christine, Hypponen, Elina, Richards, Marcus, Hardy, Rebecca, Kuh, Diana, Wareham, Nicholas, Ben-Shlomo, Yoav, Day, Ian N., Whincup, Peter, Morris, Richard, Strachan, Mark W. J., Price, Jacqueline, Kumari, Meena, Kivimaki, Mika, Plagnol, Vincent, Dudbridge, Frank, Whittaker, John C., Casas, Juan P., Hingorani, Aroon D.Enlace del recurso
Publicado 2013
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3por Lane, Christopher A., Barnes, Josephine, Nicholas, Jennifer M., Sudre, Carole H., Cash, David M., Malone, Ian B., Parker, Thomas D., Keshavan, Ashvini, Buchanan, Sarah M., Keuss, Sarah E., James, Sarah-Naomi, Lu, Kirsty, Murray-Smith, Heidi, Wong, Andrew, Gordon, Elizabeth, Coath, William, Modat, Marc, Thomas, David, Richards, Marcus, Fox, Nick C., Schott, Jonathan M.“…Participants were assessed with multimodal magnetic resonance imaging and florbetapir-amyloid positron emission tomography scans between May 2015 and January 2018 at University College London. Participants with at least 1 available imaging measure, vascular risk measurements at 1 or more points, and no dementia were included in analyses. …”
Publicado 2019
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4por Lane, Christopher A, Barnes, Josephine, Nicholas, Jennifer M, Sudre, Carole H, Cash, David M, Parker, Thomas D, Malone, Ian B, Lu, Kirsty, James, Sarah-Naomi, Keshavan, Ashvini, Murray-Smith, Heidi, Wong, Andrew, Buchanan, Sarah M, Keuss, Sarah E, Gordon, Elizabeth, Coath, William, Barnes, Anna, Dickson, John, Modat, Marc, Thomas, David, Crutch, Sebastian J, Hardy, Rebecca, Richards, Marcus, Fox, Nick C, Schott, Jonathan M“…Participants aged 69–71 years received T1 and FLAIR volumetric MRI, florbetapir amyloid-PET imaging, and cognitive assessment at University College London (London, UK); all participants were dementia-free. …”
Publicado 2019
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