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1di Gordon, Aubree, Tsang, Tim K., Cowling, Benjamin J., Kuan, Guillermina, Ojeda, Sergio, Sanchez, Nery, Gresh, Lionel, Lopez, Roger, Balmaseda, Angel, Harris, Eva“...During August 2012–November 2014, we conducted a case ascertainment study to investigate household transmission of influenza virus in Managua, Nicaragua. We collected up to 5 respiratory swab samples from each of 536 household contacts of 133 influenza virus–infected persons and assessed for evidence of influenza virus transmission. ...”
Pubblicazione 2018
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2di Wraith, Steph, Balmaseda, Angel, Carrillo, Fausto Andres Bustos, Kuan, Guillermina, Huddleston, John, Kubale, John, Lopez, Roger, Ojeda, Sergio, Schiller, Amy, Lopez, Brenda, Sanchez, Nery, Webby, Richard, Nelson, Martha I., Harris, Eva, Gordon, Aubree“...Using data from a pediatric cohort in Managua, Nicaragua, we examine the effects of natural influenza virus infection on subsequent infection with the same influenza virus subtype/lineage across multiple seasons, totaling 2,170 RT-PCR-confirmed symptomatic influenza infections. ...”
Pubblicazione 2022
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3di Hacker, Kathryn, Kuan, Guillermina, Vydiswaran, Nivea, Chowell‐Puente, Gerardo, Patel, Mayuri, Sanchez, Nery, Lopez, Roger, Ojeda, Sergio, Lopez, Brenda, Mousa, Jarrod, Maier, Hannah E., Balmaseda, Angel, Gordon, Aubree“...METHODS: NPICS is an ongoing prospective study of children in Managua, Nicaragua. We assessed children for hMPV infection via real‐time reverse‐transcription polymerase chain reaction (RT‐PCR). ...”
Pubblicazione 2022
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4di Gresh, Lionel, Kuan, Guillermina, Sanchez, Nery, Azziz-Baumgartner, Eduardo, Ojeda, Sergio, Melendez, Marlon, Lopez, Roger, Martin, Emily T., Widdowson, Marc-Alain, Bresee, Joseph, Harris, Eva, Balmaseda, Angel, Gordon, AubreeTesto
Pubblicazione 2016
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5di Kubale, John, Kuan, Guillermina, Gresh, Lionel, Ojeda, Sergio, Azziz-Baumgartner, Eduardo, Sanchez, Nery, Lopez, Roger, Harris, Eva, Balmaseda, Angel, Gordon, Aubree“...To assess the incidence rate of symptomatic RSV illness among young children, we conducted a prospective birth cohort study following children from 0–2 years of age in Managua, Nicaragua. METHODS: Children meeting the testing criteria (fever, history of fever, or severe respiratory symptoms [apnea, stridor, nasal flaring, wheezing, chest indrawing, and/or central cyanosis]) were tested for RSV infections using real-time reverse transcriptase-polymerase chain reaction. ...”
Pubblicazione 2020
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6di Kuan, Guillermina, Ramirez, Stephania, Gresh, Lionel, Ojeda, Sergio, Melendez, Marlon, Sanchez, Nery, Collado, Damaris, Garcia, Nadezna, Mercado, Juan Carlos, Gordon, Aubree, Balmaseda, Angel, Harris, Eva“...Here, we conducted two studies to analyze the seroprevalence of anti-CHIKV antibodies after the first chikungunya epidemic in a community-based cohort study (ages 2–14 years) and in a cross-sectional survey of persons aged ≥15 years in the same area of Managua, Nicaragua. Routine annual serum samples collected from 3,362 cohort participants in March/April 2014 and 2015, and 848 age-stratified samples collected from persons ≥15 years old at the end of May-beginning of June 2015 were used to estimate the seroprevalence of anti-CHIKV antibodies after the first epidemic (October 2014 to February 2015 in the study population). ...”
Pubblicazione 2016
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7di Warnes, Colin M., Carrillo, Fausto Andres Bustos, Zambrana, Jose Victor, Mercado, Brenda Lopez, Arguello, Sonia, Ampié, Oscarlette, Collado, Damaris, Sanchez, Nery, Ojeda, Sergio, Kuan, Guillermina, Gordon, Aubree, Balmaseda, Angel, Harris, Eva“...To characterize long-term chikungunya-associated arthralgia, we recruited 770 patients (105 0–4 year olds [y/o], 200 5–9 y/o, 307 10–15 y/o, and 158 16+ y/o) with symptomatic chikungunya virus infections in Managua, Nicaragua, during two chikungunya epidemics (2014–2015). ...”
Pubblicazione 2023
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8di Maier, Hannah E, Lopez, Roger, Sanchez, Nery, Ng, Sophia, Gresh, Lionel, Ojeda, Sergio, Burger-Calderon, Raquel, Kuan, Guillermina, Harris, Eva, Balmaseda, Angel, Gordon, Aubree“...This work investigates the effect of obesity on the duration of viral shedding within household transmission studies in Managua, Nicaragua, over 3 seasons (2015–2017). Symptomatic obese adults were shown to shed influenza A virus 42% longer than nonobese adults (adjusted event time ratio [ETR], 1.42; 95% confidence interval [CI], 1.06–1.89); no association was observed with influenza B virus shedding duration. ...”
Pubblicazione 2018
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9di Wagner, Abram L., Gresh, Lionel, Sanchez, Nery, Kuan, Guillermina, Kubale, John, Lopez, Roger, Ojeda, Sergio, Azziz-Baumgartner, Eduardo, Balmaseda, Angel, Gordon, Aubree“...This study (1) characterizes the burden of influenza in infants, and (2) compares signs and symptoms by prior influenza vaccination or influenza illness. Newborns from Managua, Nicaragua, were followed for two years. Data came from primary medical appointments, PCR testing, and parents’ daily symptom diaries. ...”
Pubblicazione 2021
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10di Bustos Carrillo, Fausto Andres, Mercado, Brenda Lopez, Monterrey, Jairo Carey, Collado, Damaris, Saborio, Saira, Miranda, Tatiana, Barilla, Carlos, Ojeda, Sergio, Sanchez, Nery, Plazaola, Miguel, Laguna, Harold Suazo, Elizondo, Douglas, Arguello, Sonia, Gajewski, Anna M., Maier, Hannah E., Latta, Krista, Carlson, Bradley, Coloma, Josefina, Katzelnick, Leah, Sturrock, Hugh, Balmaseda, Angel, Kuan, Guillermina, Gordon, Aubree, Harris, Eva“...We examined three metrics of infection and disease in a pediatric cohort (N≈3,000) over two chikungunya and one Zika epidemic, and in a household cohort (N=1,793) over one COVID-19 epidemic in Managua, Nicaragua. We compared spatial incidence rates (cases/total population), infection risks (infections/total population), and disease risks (cases/infected population). ...”
Pubblicazione 2022
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11di Frutos, Aaron M, Kuan, Guillermina, Lopez, Roger, Ojeda, Sergio, Shotwell, Abigail, Sanchez, Nery, Saborio, Saira, Plazaola, Miguel, Barilla, Carlos, Kenah, Eben, Balmaseda, Angel, Gordon, Aubree“...METHODS: We conducted a household cohort study from March 2020-November 2022 in Managua, Nicaragua; following a housheold SARS-CoV-2 infection, household members are closely monitored for infection. ...”
Pubblicazione 2023
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12di Frutos, Aaron M, Kuan, Guillermina, Lopez, Roger, Ojeda, Sergio, Shotwell, Abigail, Sanchez, Nery, Saborio, Saira, Plazaola, Miguel, Barilla, Carlos, Kenah, Eben, Balmaseda, Angel, Gordon, Aubree“...METHODS: We conducted a household cohort study between March 2020-June 2022 in Managua, Nicaragua where when one household member tests positive for SARS-CoV-2, household members are closely monitored for SARS-CoV-2 infection. ...”
Pubblicazione 2022
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13di Maier, Hannah E., Plazaola, Miguel, Lopez, Roger, Sanchez, Nery, Saborio, Saira, Ojeda, Sergio, Barilla, Carlos, Kuan, Guillermina, Balmaseda, Angel, Gordon, Aubree“...METHODS: We conducted a household cohort study in Managua, Nicaragua, with an embedded transmission study that closely monitors participants regardless of symptoms. ...”
Pubblicazione 2022
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14di Burger-Calderon, Raquel, Gonzalez, Karla, Ojeda, Sergio, Zambrana, José Victor, Sanchez, Nery, Cerpas Cruz, Cristhiam, Suazo Laguna, Harold, Bustos, Fausto, Plazaola, Miguel, Lopez Mercado, Brenda, Elizondo, Douglas, Arguello, Sonia, Carey Monterrey, Jairo, Nuñez, Andrea, Coloma, Josefina, Waggoner, Jesse J., Gordon, Aubree, Kuan, Guillermina, Balmaseda, Angel, Harris, Eva“...A pilot study of ZIKV infection in Nicaraguan households was conducted from August 31 to October 21, 2016, in Managua, Nicaragua. We enrolled 33 laboratory-confirmed Zika index cases and their household members (109 contacts) and followed them on days 3–4, 6–7, 9–10, and 21, collecting serum/plasma, urine, and saliva specimens along with clinical, demographic, and socio-economic status information. ...”
Pubblicazione 2018
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15di Maier, Hannah E, Kuan, Guillermina, Saborio, Saira, Carrillo, Fausto Andres Bustos, Plazaola, Miguel, Barilla, Carlos, Sanchez, Nery, Lopez, Roger, Smith, Matt, Kubale, John, Ojeda, Sergio, Zuniga-Moya, Julio C, Carlson, Bradley, Lopez, Brenda, Gajewski, Anna M, Chowdhury, Mahboob, Harris, Eva, Balmaseda, Angel, Gordon, Aubree“...METHODS: We followed 2338 people in Managua, Nicaragua, aged <94 years from March 2020 through March 2021. ...”
Pubblicazione 2021
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16di Maier, Hannah E, Nachbagauer, Raffael, Kuan, Guillermina, Ng, Sophia, Lopez, Roger, Sanchez, Nery, Stadlbauer, Daniel, Gresh, Lionel, Schiller, Amy, Rajabhathor, Arvind, Ojeda, Sergio, Guglia, Andrea F, Amanat, Fatima, Balmaseda, Angel, Krammer, Florian, Gordon, Aubree“...METHODS: We used a case-ascertained, community-based study of household influenza virus transmission set in Managua, Nicaragua. Using data from 170 reverse transcriptase–polymerase chain reaction (RT-PCR)–confirmed influenza virus A(H1N1)pdm infections and 45 household members with serologically confirmed infection, we examined the association of pre-existing NA, hemagglutination inhibiting, and HA stalk antibody levels and influenza viral shedding and disease duration using accelerated failure time models. ...”
Pubblicazione 2020
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17di Kubale, John, Balmaseda, Angel, Frutos, Aaron M., Sanchez, Nery, Plazaola, Miguel, Ojeda, Sergio, Saborio, Saira, Lopez, Roger, Barilla, Carlos, Vasquez, Gerald, Moreira, Hanny, Gajewski, Anna, Campredon, Lora, Maier, Hannah E., Chowdhury, Mahboob, Cerpas, Cristhiam, Harris, Eva, Kuan, Guillermina, Gordon, Aubree“...DESIGN, SETTING, AND PARTICIPANTS: In this prospective, community-based pediatric cohort study conducted from March 1, 2020, to October 15, 2021, 1964 nonimmunocompromised children aged 0 to 14 years were enrolled by random selection from the Nicaraguan Pediatric Influenza Cohort, a community-based cohort in District 2 of Managua, Nicaragua. Additional newborn infants aged 4 weeks or younger were randomly selected and enrolled monthly via home visits. ...”
Pubblicazione 2022
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18di Gordon, Aubree, Gresh, Lionel, Ojeda, Sergio, Katzelnick, Leah C., Sanchez, Nery, Mercado, Juan Carlos, Chowell, Gerardo, Lopez, Brenda, Elizondo, Douglas, Coloma, Josefina, Burger-Calderon, Raquel, Kuan, Guillermina, Balmaseda, Angel, Harris, Eva“...To study this potential impact, we analyzed the large 2016 Zika epidemic in Managua, Nicaragua, in a pediatric cohort with well-characterized DENV infection histories. ...”
Pubblicazione 2019
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19di Kubale, John, Balmaseda, Angel, Frutos, Aaron M, Sanchez, Nery, Plazaola, Miguel, Ojeda, Sergio, Saborio, Saira, Lopez, Roger, Barilla, Carlos, Vasquez, Gerald, Moreira, Hanny, Gajewski, Anna, Campredon, Lora, Maier, Hannah, Chowdhury, Mahboob, Cerpas, Cristhiam, Harris, Eva, Kuan, Guillermina, Gordon, Aubree“...SETTING: The Nicaraguan Pediatric Influenza Cohort is a community-based cohort in District 2 of Managua, Nicaragua. PARTICIPANTS: A total of 1964 children aged 0–14 years participated in the cohort. ...”
Pubblicazione 2022
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