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  1. 1
    “…Rates of synergy were also higher against porin mutants vs WT for MVB + FOS or COL (Figure 2). Table 1 [Figure: see text] Characteristics and susceptibility data for fifteen KPC-Kp isolates chosen for analysis. …”
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    2183. Porin Mutations Potentiate the in Vitro Synergy of Meropenem-Vaborbactam (MVB), but not Ceftazidime-Avibactam (CZA) in Combination with Other Antibiotics against KPC-producing Klebsiella Pneumoniae (KPC-Kp)
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    “…Resistant subpopulations were selected by agar plates containing MEM at 4x baseline MIC. [Figure: see text] RESULTS: Standard MEM regimens were largely not bactericidal against ECOL (Figure 1) or ENTCC (Figure 2). …”
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    1114. Exploring bactericidal activity and emergence of resistance for carbapenem-resistant Enterobacterales (CRE) with and without Klebsiella pneumoniae carbapenemase (KPC) treated with optimized meropenem (MEM) and meropenem-vaborbactam (MEV) exposures
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    “…In-hospital and 30-day mortality rates were numerically higher among patients who received inactive empiric therapy (27% and 21%, respectively) when compared to patients who received active empiric therapy (16.5% and 12%, respectively) (Figure 1). Results Table 1: Patient demographics, underlying conditions and infection and treatment characteristics in the pre-intervention group [Figure: see text] Results Table 2 [Figure: see text] Results Figure 1 [Figure: see text] CONCLUSION: Our pre-intervention data highlight opportunities to improve the management of GN bacteremia. …”
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    144. Impact of Rapid Identification and Resistance Gene Detection using an Algorithm-Based Approach in Gram-Negative Bacteremia
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    “…Using both CAS and AFG MICs was most predictive of FKS mutations (Fig. 3). [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: ECH resistance among C. glabrata stabilized or decreased over 11-years at our hospital, in keeping with stewardship interventions to reduce prolonged use of ECHs. …”
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    752. Decreased Echinocandin Resistance among Candida glabrata over an Eleven-Year Period at a University Hospital
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    “…Among patients prescribed antimicrobials during an index admission, 30-day re-admissions decreased from 330 to 262 and re-admissions associated with re-ordering of antimicrobials decreased from 235 to 182 (Fig 4). [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: Custom-designed, task-specific software improves the efficiency of daily ASP workflow and significantly decreased antimicrobial utilization without the need for additional ASP team members. …”
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    916. Increased efficiency and impact of implementing ILUM insight within an antimicrobial stewardship program (ASP) at an academic medical center
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    “…Time to a composite endpoint of recurrent infection or death within 90 days was similar between groups in the overall analysis and the subgroup of patients with pneumonia (Figure 2). [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: In this interim analysis of the CACTUS study, patients treated with CT and CZA had similar clinical outcomes. …”
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    1109. A multicenter, observational study to compare the effectiveness of Ceftazidime-Avibactam versus Ceftolozane-Tazobactam for multidrug-resistant Pseudomonas aeruginosa infections in the United States (CACTUS)
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    “…A trend toward decreased 30-day mortality was identified in the post-RDT period (P=0.06). [Figure: see text] [Figure: see text] CONCLUSION: Our study highlights the impact of RDT with ASP intervention on clinical outcomes for patients with Streptococcal bacteremia. …”
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    94. Rapid Diagnostic Testing is Associated with Decreased Broad Spectrum Antibiotic Use in Streptococcal Blood Stream Infections
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    “…R2-loop substitutions were observed in FDC-exposed resistant strains, whereas Ω-loop mutations were observed in resistant strains that had not been exposed to FDC. Figure 1. [Figure: see text] Alignment of amino acid sequences in the ADC Ω- and R2- loop regions among studied isolates. …”
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    2134. Impact of ADC ß-lactamase amino acid variation on cefiderocol (FDC) susceptibility in carbapenem-resistant Acinetobacter baumannii (CRAb) strains
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    “…Safety outcomes included rates of recurrent BSI and hospital readmission. [Figure: see text] RESULTS: 184 patients were included (Fig 2). …”
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    912. Impact of Rapid Identification and Stewardship Intervention on Coagulase-negative Staphylococcus Bloodstream Infection (BSI)
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    “…Patient demographics, severity of illness, infection and treatment characteristics based on definitive therapy [Figure: see text] Results Table 2 [Figure: see text] Results Table 3 [Figure: see text] CONCLUSION: Definitive tx with dose-optimized TZP did not lead to worse clinical or microbiologic outcomes compared to FEP, CB and FQ. …”
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    2775. Clinical Outcomes and Treatment-Emergent Resistance of Piperacillin-tazobactam, Cefepime, Carbapenems and Fluoroquinolones for the Treatment of Bloodstream Infections due to AmpC β-Lactamase-Producing Enterobacterales
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    “…She had high PP of NS (NTF 10.3%, SXT 97.2%, FQs 96.4%, BLs 48.0%) and was categorized as high risk for all ABX classes. [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: AMR risk varied greatly between patients. …”
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    2838. Clinical Application and Validation of a Predictive Antimicrobial Resistance Risk Categorization Framework for Patients with Uncomplicated Urinary Tract Infection
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    “…All were related by WGS and harbored CMY-145, NDM-5, and a YRIN duplication in PBP3. [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: During a multi-species NDM outbreak we found ATM-AVI and FEP-TAN demonstrated potent in vitro activity against clinical isolates. …”
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    2185. In vitro activity of aztreonam-avibactam (ATM-AVI), cefiderocol (FDC), and cefepime-taniborbactam (FEP-TAN) against multi-species, NDM-producing Enterobacterales causing a local outbreak
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    “…CT resistance was associated with new ampC mutations in 83% of pairs. [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: In this non-matched, descriptive analysis, tx-emergent resistance occurred more commonly among pts treated with CZA compared to CT for MDR P. aeruginosa infections. …”
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    2186. Treatment-emergent resistance to ceftazidime-avibactam (CZA) is more common than ceftolozane-tazobactam (CT) among patients infected with multidrug-resistant (MDR) Pseudomonas aeruginosa
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    “…Thirty-day mortality rates were highest for CRE (30.1%) and BLR P. aeruginosa (BLR-Pa; 32.8%, Figure 1). 47.7% of BLR GNB were non-CRE/ESBL, which demonstrated higher mortality rates than CRE/ESBL (30 days; 27.6% vs. 21.2%; P = 0.048). …”
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    656. Prioritizing Gram-Negative Bacteremia (GNB) Cases for Rapid Detection by β-Lactam Resistance (BLR) and Patient Outcomes
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    “…Combination therapy versus monotherapy [Figure: see text] Factors associated with clinical failure [Figure: see text] CONCLUSION: To our knowledge, this is the largest study of Pseudomonas endocarditis to date. …”
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    2410. Clinical outcomes and antimicrobial management strategies of Pseudomonas endocarditis
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    “…IFI was an independent risk factor for death at 1 year (Figure 2, P < 0.0001, Kaplan–Meier). CONCLUSION: ISA was as effective as VOR in preventing IFI in LTR, and significantly better tolerated. …”
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    89. Efficacy and Tolerability of Voriconazole (VOR) vs. Isavuconazole (ISA) Prophylaxis (px) in Preventing Invasive Fungal Infections (IFI) in Lung Transplant Recipients (LTR)
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    “…In combo with M/V, rates of synergy (>2-log kill in combo) with COL, FOS, GEN, and TGC were 44%, 19%, 12.5%, and 12.5%, respectively (Figure 2). Corresponding rates of bactericidal activity were 44%, 25%, 69%, and 31%, respectively. …”
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    1580. Colistin Potentiates the In Vitro Activity of Meropenem–Vaborbactam (M/V) Against Some, but not All KPC-producing Klebsiella pneumoniae (KPC-Kp)
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    “…ERV MICs determined by BMD and MTS were well-correlated showing 89% essential agreement (MIC within one 2-fold dilution; Figure). The rate of categorical agreement (CA) was 73%. …”
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    710. In Vitro Activity and Performance of Available Susceptibility Testing Methods for Eravacycline Against Carbapenem-Resistant Enterobacteriaceae (CRE)
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    “…CNSC rates increased from 4% in 2000 to 10% in 2018 (R(2) = 0.206, P = 0.05), as did carbapenem consumption (6.5–34.5 DDDs/1000, R(2) = 0.831, P < 0.001) (Figure 1). Twenty-one isolates from 19 patients were available for additional analysis. …”
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    485. Clinical and Molecular Epidemiology of Carbapenem Non-susceptible Citrobacter sp.
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    “…AF consumption was decreased 47% (figure). CONCLUSION: Targeted DS using T2 in select ICU patients with sepsis significantly reduced AF usage. 14% of patients with sepsis were diagnosed with IC using either T2+ or BC+, compared with 7% with BC+ alone, as would be expected if BC S was 50%. …”
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    2033. Incorporating T2Candida Testing into Rational Antifungal (AF) Management: A Successful Pilot Study of Diagnostic Stewardship (DS) Directed Toward Specific Intensive Care Unit (ICU) Patients At-Risk for Sepsis due to Invasive Candidiasis (IC)
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