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1por Blum, Kenneth, Kazmi, Shan, Modestino, Edward J., Downs, Bill William, Bagchi, Debasis, Baron, David, McLaughlin, Thomas, Green, Richard, Jalali, Rehan, Thanos, Panayotis K., Elman, Igor, Badgaiyan, Rajendra D., Bowirrat, Abdalla, Gold, Mark S.“…The formulations are based on the results of the addiction risk severity (GARS) test. Based on both neurogenetic and epigenetic evidence, the test evaluates the presence of reward genes and risk alleles. …”
Publicado 2021
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2por Moran, Mark, Blum, Kenneth, Ponce, Jessica Valdez, Lott, Lisa, Gondré–Lewis, Marjorie C., Badgaiyan, Sampada, Brewer, Raymond, Downs, B. William, Fynman, Philip, Weingarten, Alexander, Cadet, Jean Lud, Smith, David E., Baron, David, Thanos, Panayotis K., Modestino, Edward J., Badgaiyan, Rajendra D., Elman, Igor, Gold, Mark S.“…Evaluation of pain clinic patients with the Genetic Addiction Risk Score (GARS) test and the Addiction Severity Index (ASI- Media Version V) revealed that GARS scores equal to or greater than 4 and 7 alleles significantly predicted drug and alcohol severity, respectively. …”
Publicado 2021
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3por Modestino, Edward Justin, Blum, Kenneth, Dennen, Catherine A., Downs, B. William, Bagchi, Debasis, Llanos-Gomez, Luis, Elman, Igor, Baron, David, Thanos, Panayotis K., Badgaiyan, Rajendra D., Braverman, Eric R., Gupta, Ashim, Gold, Mark S., Bowirrat, AbdallaEnlace del recurso
Publicado 2022
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4por Blum, Kenneth, Han, David, Gupta, Ashim, Baron, David, Braverman, Eric R., Dennen, Catherine A., Kazmi, Shan, Llanos-Gomez, Luis, Badgaiyan, Rajendra D., Elman, Igor, Thanos, Panayotis K., Downs, Bill W., Bagchi, Debasis, Gondre-Lewis, Marjorie C., Gold, Mark S., Bowirrat, Abdalla“…While most of the research related to GARS is derived from our laboratory, we are encouraging more independent research to confirm our findings.…”
Publicado 2022
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5por Blum, Kenneth, Brodie, Mark S., Pandey, Subhash C., Cadet, Jean Lud, Gupta, Ashim, Elman, Igor, Thanos, Panayotis K., Gondre-Lewis, Marjorie C., Baron, David, Kazmi, Shan, Bowirrat, Abdalla, Febo, Marcelo, Badgaiyan, Rajendra D., Braverman, Eric R., Dennen, Catherine A., Gold, Mark S.“…We present a hypothesis that identification of KCNK13 and RASGRF2 genes’ risk polymorphism, coupled with genetic addiction risk score (GARS)-guided precision pro-dopamine regulation, will mitigate binge alcohol drinking. …”
Publicado 2022
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6por Ceccanti, Mauro, Blum, Kenneth, Bowirrat, Abdalla, Dennen, Catherine A., Braverman, Eric R., Baron, David, Mclaughlin, Thomas, Giordano, John, Gupta, Ashim, Downs, Bernard W., Bagchi, Debasis, Barh, Debmalya, Elman, Igor, Thanos, Panayotis K., Badgaiyan, Rajendra D., Edwards, Drew, Gold, Mark S.“…Therefore, based on this extensive literature and additional research, this team of coauthors suggests that, in the future, in addition to the current nonpharmacological therapies, patients with opioid-induced NAS should undergo genetic assessment (i.e., the genetic addiction risk severity (GARS) test), which can subsequently be used to guide DNA-directed precision amino-acid enkephalinase inhibition (KB220) therapy as a frontline modality instead of potent opioids.…”
Publicado 2022
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7por Thanos, Panayotis K., Hanna, Colin, Mihalkovic, Abrianna, Hoffman, Aaron B., Posner, Alan R., Busch, John, Smith, Caroline, Badgaiyan, Rajendra D., Blum, Kenneth, Baron, David, Mastrandrea, Lucy D., Quattrin, Teresa“…Of the 11 risk alleles identified by GARS, the DRD4 risk allele (rs1800955), was significantly correlated with change in weight and BMI six months post-surgery. …”
Publicado 2023
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8por Dennen, Catherine A., Blum, Kenneth, Bowirrat, Abdalla, Thanos, Panayotis K., Elman, Igor, Ceccanti, Mauro, Badgaiyan, Rajendra D., McLaughlin, Thomas, Gupta, Ashim, Bajaj, Anish, Baron, David, Downs, B. William, Bagchi, Debasis, Gold, Mark S.“…This case series presents the novel genetic addiction risk score (GARS), which shows a high prevalence of polymorphic risk alleles of reward genes in a nuclear family with multiple reward deficiency syndrome (RDS) behavioral issues expressing a hypodopaminergic antecedent. …”
Publicado 2022
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9por Blum, Kenneth, Han, David, Bowirrat, Abdalla, Downs, Bernard William, Bagchi, Debasis, Thanos, Panayotis K., Baron, David, Braverman, Eric R., Dennen, Catherine A., Gupta, Ashim, Elman, Igor, Badgaiyan, Rajendra D., Llanos-Gomez, Luis, Khalsa, Jag, Barh, Debmalya, McLaughlin, Thomas, Gold, Mark S.“…To develop an accurate test to help identify those at risk for at least alcohol use disorder (AUD), a subset of reward deficiency syndrome (RDS), Blum’s group developed the genetic addiction risk severity (GARS) test, consisting of ten genes and eleven associated risk alleles. …”
Publicado 2022
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10por Thanos, Panayotis K., Hanna, Colin, Mihalkovic, Abrianna, Hoffman, Aaron, Posner, Alan, Butsch, John, Blum, Kenneth, Georger, Lesley, Mastrandrea, Lucy D., Quattrin, Teresa“…Thirty (30) patients were assessed for Genetic Addiction Risk Severity (GARS), which analyzes neurogenetic polymorphisms involved in addiction and reward deficiency. …”
Publicado 2023
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11por Blum, Kenneth, Bowirrat, Abdalla, Braverman, Eric R, Dennen, Catherine, Zeine, Foojan, Jafari, Nicole, Sunder, Keerthy, Thanos, Panayotis K., Baron, David, Barh, Debmayla, Gupta, Ashim, Bagchi, Debasis, Gold, Mark S, Badgaiyan, Rajendra D.“…The development of the Genetic Addiction Risk Severity (GARS) test, Blum’s group believes that this type of testing should be the “standard of care” following additional studies. …”
Publicado 2023
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12por Blum, Kenneth, Bowirrat, Abdala, Elman, Igor, Baron, David, Thanos, Panayotis K., Gold, Mark S, Hanna, Colin, Makale, Milan T., Sunder, Keerthy, Jafari, Nicole, Zeine, Foojan, Murphy, Kevin T., Makale, Miles, Badgaiyan, Rajendra D.“…Several from Blum et al. showed the clinical relevance of the Genetic Addiction Risk Severity (GARS) test in identifying risk for reward deficiency behaviors in cohorts from polysubstance and pain clinics, post-surgical bariatrics, and DWI offenders facing prison time. …”
Publicado 2023
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13por Blum, Kenneth, Dennen, Catherine A., Elman, Igor, Bowirrat, Abdalla, Thanos, Panayotis K., Badgaiyan, Rajendra D., Downs, B. William, Bagchi, Debasis, Baron, David, Braverman, Eric R., Gupta, Ashim, Green, Richard, McLaughlin, Thomas, Barh, Debmalya, Gold, Mark S.“…Epigenetic repair of hypodopaminergia, the causative basis of addictive behaviors, may involve precision DNA-guided therapy achieved by combining the Genetic Addiction Risk Severity (GARS) test with a researched neutraceutical having a number of variant names, including KB220Z. …”
Publicado 2022
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