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1por Falet, Hervé, Pollitt, Alice Y., Begonja, Antonija Jurak, Weber, Sarah E., Duerschmied, Daniel, Wagner, Denisa D., Watson, Steve P., Hartwig, John H.“…Unexpectedly, however, immunoreceptor tyrosine-based activation motif (ITAM)- and ITAM-like–mediated signals are severely compromised in FlnA-null platelets. …”
Publicado 2010
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2por Hughes, Craig E., Sinha, Uma, Pandey, Anjali, Eble, Johannes A., O'Callaghan, Christopher A., Watson, Steve P.“…These results further emphasize the distinct nature of the proximal events in signaling by hemITAM relative to ITAM receptors.…”
Publicado 2013
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3por Hardy, Alexander T., Palma-Barqueros, Verónica, Watson, Stephanie K., Malcor, Jean-Daniel, Eble, Johannes A., Gardiner, Elizabeth E., Blanco, José E., Guijarro-Campillo, Rafael, Delgado, Juan L., Lozano, María L., Teruel-Montoya, Raúl, Vicente, Vicente, Watson, Steve P., Rivera, José, Ferrer-Marín, Francisca“…Phosphorylation of a conserved YxxL sequence known as a (hemi) immunotyrosine-based-activation-motif (ITAM) in both receptors is critical for Syk activation. …”
Publicado 2018
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4por Séverin, Sonia, Pollitt, Alice Y., Navarro-Nuñez, Leyre, Nash, Craig A., Mourão-Sá, Diego, Eble, Johannes A., Senis, Yotis A., Watson, Steve P.“…These results provide the first definitive evidence that Syk mediates phosphorylation of the CLEC-2 hemITAM receptor with Src family kinases playing a critical role further downstream through the regulation of Syk and other effector proteins, providing a new paradigm in signaling by YXXL-containing receptors.…”
Publicado 2011
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5por Mori, Jun, Pearce, Andrew C., Spalton, Jennifer C., Grygielska, Beata, Eble, Johannes A., Tomlinson, Michael G., Senis, Yotis A., Watson, Steve P.“…In this study we show that two platelet glycoprotein receptors that signal via an immunoreceptor tyrosine-based activation motif (ITAM) or an ITAM-like domain, namely the collagen receptor complex glycoprotein VI (GPVI)-FcR γ-chain and the C-type lectin-like receptor 2 (CLEC-2), respectively, support constitutive (i.e. agonist-independent) signaling in a cell line model using a nuclear factor of activated T-cells (NFAT) transcriptional reporter assay that can detect low level activation of phospholipase Cγ (PLCγ). …”
Publicado 2008
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