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1por Lawn, Stephen D, Meintjes, Graeme, McIlleron, Helen, Harries, Anthony D, Wood, Robin“…Outcomes of rifampicin-based TB treatment are greatly enhanced by concurrent co-trimoxazole prophylaxis and antiretroviral therapy (ART). ART reduces mortality across a spectrum of CD4 counts and randomized controlled trials have defined the optimum time to start ART. …”
Publicado 2013
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2por Brinkhof, Martin W. G., Spycher, Ben D., Yiannoutsos, Constantin, Weigel, Ralf, Wood, Robin, Messou, Eugène, Boulle, Andrew, Egger, Matthias, Sterne, Jonathan A. C.“…BACKGROUND: Evaluation of antiretroviral treatment (ART) programmes in sub-Saharan Africa is difficult because many patients are lost to follow-up. …”
Publicado 2010
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3por Longley, Nicky, Jarvis, Joseph Nicholas, Meintjes, Graeme, Boulle, Andrew, Cross, Anna, Kelly, Nicola, Govender, Nelesh P., Bekker, Linda-Gail, Wood, Robin, Harrison, Thomas S.“…Patients were started on ART between 2 and 4 weeks and followed up for 1 year. …”
Publicado 2016
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4“…INTRODUCTION: Although antiretroviral therapy (ART) reduces individual tuberculosis (TB) risk by two-thirds, the population-level impact remains uncertain. …”
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5por Kaplan, Richard, Hermans, Sabine, Caldwell, Judy, Jennings, Karen, Bekker, Linda-Gail, Wood, Robin“…BACKGROUND: In Cape Town, the roll-out of antiretroviral therapy (ART) has increased over the last decade with an estimated coverage of 63% of HIV- positive patients in 2013. …”
Publicado 2018
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6por Orrell, Catherine, Cohen, Karen, Leisegang, Rory, Bangsberg, David R., Wood, Robin, Maartens, Gary“…BACKGROUND: Incomplete adherence to antiretroviral therapy (ART) results in virologic failure and resistance. …”
Publicado 2017
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7“…We, therefore, assessed TB treatment outcomes in relation to HIV infection and antiretroviral therapy (ART) among TB patients attending a primary care service with co-located ART and TB clinics in Cape Town, South Africa. …”
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8por Lawn, Stephen D, Campbell, Lucy, Kaplan, Richard, Little, Francesca, Morrow, Carl, Wood, Robin“…We examined the timing of ART among patients receiving care provided by non-integrated TB and ART services in Cape Town, South Africa. …”
Publicado 2011
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9por April, Michael D., Wood, Robin, Berkowitz, Bethany K., Paltiel, A. David, Anglaret, Xavier, Losina, Elena, Freedberg, Kenneth A., Walensky, Rochelle P.“…Model inputs included cohort-specific mean CD4(+) T-cell count at ART initiation (112–178 cells/µL), 24-week ART suppressive efficacy (78%), second-line ART availability (2.4% of ART recipients), and cohort-specific 36-month retention rate (55%–71%). …”
Publicado 2014
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10por Levison, Julie H., Orrell, Catherine, Gallien, Sébastien, Kuritzkes, Daniel R., Fu, Naishin, Losina, Elena, Freedberg, Kenneth A., Wood, Robin“…HIV-1 RNA subtype C predominated (n = 32, 97%). Mean duration on ART (SD) prior to initiation of second-line ART was 23 (17) months, and time from second-line ART initiation to failure was 10 (9) months. …”
Publicado 2012
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11por Schomaker, Michael, Egger, Matthias, Ndirangu, James, Phiri, Sam, Moultrie, Harry, Technau, Karl, Cox, Vivian, Giddy, Janet, Chimbetete, Cleophas, Wood, Robin, Gsponer, Thomas, Bolton Moore, Carolyn, Rabie, Helena, Eley, Brian, Muhe, Lulu, Penazzato, Martina, Essajee, Shaffiq, Keiser, Olivia, Davies, Mary-Ann“…The estimated cumulative mortality after 3 y for ART initiation at different CD4 thresholds ranged from 3.4% (95% CI: 2.1–6.5) (no ART) to 2.1% (95% CI: 1.3%–3.5%) (ART irrespective of CD4 value). …”
Publicado 2013
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12por Kerkhoff, Andrew D, Wood, Robin, Cobelens, Frank G, Gupta-Wright, Ankur, Bekker, Linda-Gail, Lawn, Stephen D“…We therefore examined these issues using data from a well-characterised cohort of patients initiating ART in South Africa. METHODS: Prospectively collected clinical and haematological data were retrospectively analysed from patients receiving ART in a South African township ART service. …”
Publicado 2014
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13por Kranzer, Katharina, Zeinecker, Jennifer, Ginsberg, Philip, Orrell, Catherine, Kalawe, Nosindiso N., Lawn, Stephen D., Bekker, Linda-Gail, Wood, Robin“…BACKGROUND: Antiretroviral therapy (ART) has been scaled-up rapidly in Africa. Programme reports typically focus on loss to follow-up and mortality among patients receiving ART. …”
Publicado 2010
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14por Cornell, Morna, Schomaker, Michael, Garone, Daniela Belen, Giddy, Janet, Hoffmann, Christopher J., Lessells, Richard, Maskew, Mhairi, Prozesky, Hans, Wood, Robin, Johnson, Leigh F., Egger, Matthias, Boulle, Andrew, Myer, Landon“…We examined the magnitude of and risk factors for gender differences in mortality on ART. METHODS AND FINDINGS: Analyses included 46,201 ART-naïve adults starting ART between January 2002 and December 2009 in eight ART programmes across South Africa (SA). …”
Publicado 2012
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15por Davies, Mary-Ann, Phiri, Sam, Wood, Robin, Wellington, Maureen, Cox, Vivian, Bolton-Moore, Carolyn, Timmerman, Venessa, Moultrie, Harry, Ndirangu, James, Rabie, Helena, Technau, Karl, Giddy, Janet, Maxwell, Nicola, Boulle, Andrew, Keiser, Olivia, Egger, Matthias, Eley, Brian“…BACKGROUND: Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. …”
Publicado 2013
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16por Zaniewski, Elizabeth, Dao Ostinelli, Cam H, Chammartin, Frédérique, Maxwell, Nicola, Davies, Mary‐Ann, Euvrard, Jonathan, van Dijk, Janneke, Bosomprah, Samuel, Phiri, Sam, Tanser, Frank, Sipambo, Nosisa, Muhairwe, Josephine, Fatti, Geoffrey, Prozesky, Hans, Wood, Robin, Ford, Nathan, Fox, Matthew P, Egger, Matthias“…INTRODUCTION: The World Health Organization (WHO) recommends a CD4 cell count before starting antiretroviral therapy (ART) to detect advanced HIV disease, and routine viral load (VL) testing following ART initiation to detect treatment failure. …”
Publicado 2020
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17“…BACKGROUND: Patients with prevalent or incident tuberculosis (TB) in antiretroviral treatment (ART) programmes in sub-Saharan Africa have high mortality risk. …”
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18por Calmy, Alexandra, Balestre, Eric, Bonnet, Fabrice, Boulle, Andrew, Sprinz, Eduardo, Wood, Robin, Delaporte, Eric, Messou, Eugène, McIntyre, James, El Filali, Kamal Marhoum, Schechter, Mauro, Kumarasamy, N, Bangsberg, David, McPhail, Patrick, Van Der Borght, Stefaan, Zala, Carlos, Egger, Matthias, Thiébaut, Rodolphe, Dabis, François“…BACKGROUND: Changes in CD4 cell counts are poorly documented in individuals with low or moderate-level viremia while on antiretroviral treatment (ART) in resource-limited settings. We assessed the impact of on-going HIV-RNA replication on CD4 cell count slopes in patients treated with a first-line combination ART. …”
Publicado 2012
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19por Rasmussen, Thomas A, Ahuja, Sunil K, Kuwanda, Locadiah, Vjecha, Michael J, Hudson, Fleur, Lal, Luxshimi, Rhodes, Ajantha, Chang, Judy, Palmer, Sarah, Auberson-Munderi, Paula, Mugerwa, Henry, Wood, Robin, Badal-Faesen, Sharlaa, Pillay, Sandy, Mngqibisa, Rosie, LaRosa, Alberto, Hildago, Jose, Petoumenos, Kathy, Chiu, Chris, Lutaakome, Joseph, Kitonsa, Jonathan, Kabaswaga, Esther, Pala, Pietro, Ganoza, Carmela, Fisher, Katie, Chang, Christina, Lewin, Sharon R, Wright, Edwina J“…We investigated the role of CD4+ count at ART initiation for HIV persistence on ART. METHODS: Among participants of the Strategic Timing of Antiretroviral Treatment Study, we enrolled people with HIV (PWH) who initiated ART with CD4+ T-cell counts of 500–599, 600–799, or ≥ 800 cells/mm(3). …”
Publicado 2022
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20por Ahonkhai, Aima A., Noubary, Farzad, Munro, Alison, Stark, Ruth, Wilke, Marisa, Freedberg, Kenneth A., Wood, Robin, Losina, Elena“…We distinguished among patients with early death, within the first 7 months on ART; patients with interruptions in laboratory monitoring (ILM), defined as missing visits in the first 7 months on ART, but returning to care by 12 months; and those LTFU, defined as missing all follow-up visits in the first 12 months on ART. …”
Publicado 2012
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