por
Nakane, Takeichiro,
Masumoto, Hidetoshi,
Tinney, Joseph P.,
Yuan, Fangping,
Kowalski, William J.,
Ye, Fei,
LeBlanc, Amanda J.,
Sakata, Ryuzo,
Yamashita, Jun K.,
Keller, Bradley B.
Publicado 2017
“…We explored multiple 15 × 15 mm ECT geometries using molds with rectangular internal staggered posts (mesh, ME), without posts (plain sheet, PS), or long parallel posts (multiple linear bundles, ML) and a gel matrix containing hiPSC-derived cardiomyocytes, endothelial, and vascular
mural cells matured in vitro for 14 days. ME-ECTs displayed the lowest dead cell ratio (p < 0.001) and matured into 0.5 mm diameter myofiber bundles with greater 3D cell alignment and higher active stress than PS-ECTs. …”
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