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  1. 1
    “…CONCLUSION: The shared sequence variants and hemoglobin trait between Sherpas and Tibetans indicate a shared genetic basis for high‐altitude adaptation, consistent with the proposal that Sherpas are in fact a recently derived population from Tibetans and they inherited adaptive variants for high‐altitude adaptation from their Tibetan ancestors.…”
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    Sherpas share genetic variations with Tibetans for high‐altitude adaptation
  2. 2
    “…Tibetans are well adapted to high-altitude hypoxia. Previous genome-wide scans have reported many candidate genes for this adaptation, but only a few have been studied. …”
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    GCH1 plays a role in the high-altitude adaptation of Tibetans
  3. 3
    “…High-altitude adaptation of Tibetans represents a remarkable case of natural selection during recent human evolution. …”
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    Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
  4. 4
    “…BACKGROUND: Tibetans are genetically adapted to high-altitude environments. Though many studies have been conducted, the genetic basis of the adaptation remains elusive due to the poor reproducibility for detecting selective signatures in the Tibetan genomes. …”
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    Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans
  5. 5
    “…Tibetans are well adapted to the hypoxic environments at high altitude, yet the molecular mechanism of this adaptation remains elusive. …”
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    Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia
  6. 6
    “…The genetic adaptation of Tibetans to high altitude hypoxia likely involves a group of genes in the hypoxic pathway, as suggested by earlier studies. …”
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    EP300 contributes to high-altitude adaptation in Tibetans by regulating nitric oxide production
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    The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure
  8. 8
    “…The present study was designed to investigate the effect of high altitude hypoxia on blood parameters and tibial growth plate development in chickens using the complete blood count, morphology, and histological examination. …”
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    High altitude hypoxia as a factor that promotes tibial growth plate development in broiler chickens
  9. 9
    “…Altitude acclimatization is a human physiological process of adjusting to the decreased oxygen availability. …”
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    Using Composite Phenotypes to Reveal Hidden Physiological Heterogeneity in High-Altitude Acclimatization in a Chinese Han Longitudinal Cohort
  10. 10
    “…We provided a comprehensive phenotypic atlas by comparing altitude adaptation and altitude acclimatization. We found the differences between adaptation and acclimatization are quantitative rather than qualitative, with a whole-system “blunted effect” seen in the adapted Tibetans. …”
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    Deep phenotyping of 11,880 highlanders reveals novel adaptive traits in native Tibetans
  11. 11
    “…The best planting altitude of corn is 0 ∼ 1000 m. When the altitude is higher than 1000 m, the corn biomass gradually decreases. …”
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    Construction of Remote Sensing Model of Fresh Corn Biomass Based on Neural Network
  12. 12
    “…We investigated Japanese encephalitis virus (JEV) prevalence in high-altitude regions of Tibet, China, by using standard assays to test mosquitoes, pigs, and humans. …”
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    Epidemiologic Survey of Japanese Encephalitis Virus Infection, Tibet, China, 2015
  13. 13
    “…METHODS: In our experiments, the mice were divided randomly into four groups as flatland group, high altitude saline-treated group, high altitude FJJOL-treated group, and high altitude diazepam-treated group. …”
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    Metabolomic Analysis of Anti-Hypoxia and Anti-anxiety Effects of Fu Fang Jin Jing Oral Liquid
  14. 14
    “…The aims of this study are to quantify the relationship between geographic information (i.e., latitude, longitude and altitude) and cumulative infected population, and to unveil the importance of the population density in the spreading speed during the lockdown. …”
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    Impacts of geographic factors and population density on the COVID-19 spreading under the lockdown policies of China
  15. 15
    “…In this study, we found that, compared to low-altitude Arbor Acres chickens (AACs), high-altitude Tibetan chickens showed higher tibial vascular distributions that were accompanied by up-regulation of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor A (VEGFA) and VEGF receptors. …”
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    Tibial dyschondroplasia is highly associated with suppression of tibial angiogenesis through regulating the HIF-1α/VEGF/VEGFR signaling pathway in chickens
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    “…Sherpas living around the Himalayas are renowned as high-altitude mountain climbers but when and where the Sherpa people originated from remains contentious. …”
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    Genetic evidence of a recent Tibetan ancestry to Sherpas in the Himalayan region
  17. 17
    “…Our comparison of accessions also incorporated the altitude (indicated in meters) above sea level at which they were originally collected. …”
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    Natural variation in stress response induced by low CO(2) in Arabidopsis thaliana
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    “…Elymus nutans is more suitable for growing in warm environments at low altitude compared to Kobresia pygmaea. K. pygmaea and E. nutans were sampled along an altitude gradient in the natural grassland of Qinghai-Tibet Plateau, China. …”
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    New insight into the divergent responses of plants to warming in the context of root endophytic bacterial and fungal communities
  19. 19
    “…The risk factors of infection were found to be associated with feed type, age and altitude. CONCLUSIONS: The present study depicts a serious concern with a new emerging infectious disease in Tibetan pigs in Tibet, China.…”
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    Seroprevalence and risk factors associated with Pseudorabies virus infection in Tibetan pigs in Tibet
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    “…These findings are also useful and valuable for genetic and high-altitude research in the Tibet Autonomous Region.…”
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    First Report of Fecal Microflora of Wild Bar-Headed Goose in Tibet Plateau
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