Mostrando 1 - 20 Resultados de 47 Para Buscar '"The OA"', tiempo de consulta: 0.47s Limitar resultados
  1. 1
    “…INTRODUCTION: Observational data suggest that vitamin D deficiency is associated with the onset and progression of knee osteoarthritis (OA). However, randomised controlled trials (RCTs) to date investigating the efficacy of vitamin D supplementation in knee OA have reported conflicting results. …”
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    Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis
  2. 2
    “…INTRODUCTION: Osteoarthritis (OA) is one of the leading chronic conditions in the older population. …”
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    Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries
  3. 3
    “…BACKGROUND: Based on small to moderate effect sizes for the wide range of symptomatic treatments in osteoarthritis (OA), and on the heterogeneity of OA patients, treatment guidelines for OA have stressed the need for research on clinical predictors of response to different treatments. …”
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    Individual patient data meta-analysis of trials investigating the effectiveness of intra-articular glucocorticoid injections in patients with knee or hip osteoarthritis: an OA Trial Bank protocol for a systematic review
  4. 4
    “…INTRODUCTION: Symptomatic treatments for osteoarthritis (OA) provide only small-to-moderate efficacy over placebo in randomised controlled trials (RCTs). …”
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    Identifying predictors of response to oral non-steroidal anti-inflammatory drugs and paracetamol in osteoarthritis: a hypothesis-driven protocol for an OA Trial Bank individual participant data meta-analysis
  5. 5
    “…BACKGROUND: The burden of osteoarthritis (OA) in UK primary care has not been investigated thoroughly. …”
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    Healthcare utilisation and mortality in people with osteoarthritis in the UK: findings from a national primary care database
  6. 6
    “…OBJECTIVE: To determine the burden of comorbidities in OA and their temporal relationships in the UK. METHODS: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. …”
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    Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting
  7. 7
    “…Symptomatic hand OA was defined as the presence of both symptoms and radiographic OA in the same hand. …”
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    Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study
  8. 8
    “…Cases had clinically severe symptoms and radiographic knee or hip OA; controls had no symptoms and no radiographic knee or hip OA. …”
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    Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study
  9. 9
    “…DESIGN: This study used two-sample Mendelian Randomisation (MR). To select the OA genetic instruments, we used data from the largest recent genome-wide association study (GWAS) of OA (GO Consortium), with a focus on OA of the knee (62,497 cases, 333,557 controls), hip (35,445 cases, 316,943 controls) and hand (20,901 cases, 282,881 controls). …”
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    Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study
  10. 10
    “…AIM: To study the risk of receiving a new (incident) osteoarthritis (OA) diagnosis in different joint sites based on conditions diagnosed in the 20 years prior the OA diagnosis. …”
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    The association between preexisting conditions and osteoarthritis development in peripheral joints: A population based nested case-control study
  11. 11
    “…Cases had clinically severe symptoms and radiographic knee or hip OA; controls had no symptoms and no radiographic knee/hip OA. …”
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    Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis
  12. 12
    “…BACKGROUND: Comorbidities are common in patients with osteoarthritis (OA). This study aimed to determine the association of a wide range of previously diagnosed comorbidities in adults with newly diagnosed OA compared with matched controls without OA. …”
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    Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data
  13. 13
    “…A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA). We examined the role of the FTO polymorphism rs8044769 in risk of knee and hip OA in cases and controls incorporating body mass index (BMI) information. …”
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    The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study
  14. 14
    “…Participants were grouped into single sex knee OA, hip OA or control groups. Adjusted odds ratios (aOR) and 95% confidence interval (CI) were calculated. …”
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    Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study
  15. 15
    “…For (i), we analysed the association between starting NSAIDs and the risk of incident outcome events in the 6 years following NSAID dispensation among people with prevalent OA vs no OA. For (ii) we studied the effect of discontinuing NSAIDs among people with and without OA up to 120 days. …”
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    Does osteoarthritis modify the association between NSAID use and risk of comorbidities and adverse events?
  16. 16
    “…OBJECTIVE: To assess if a coding variant in the gene encoding transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is associated with genetic risk of painful knee osteoarthritis (OA). METHODS: The Ile585Val TRPV1 variant encoded by rs8065080 was genotyped in 3270 cases of symptomatic knee OA, 1098 cases of asymptomatic knee OA and 3852 controls from seven cohorts from the UK, the USA and Australia. …”
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    The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis
  17. 17
    “…BACKGROUND: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. …”
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    Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis
  18. 18
    “…OBJECTIVES: The role of inflammation in OA is controversial and it is unclear whether suppressing inflammation with conventional or biologic DMARDs is effective. …”
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    Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: a meta-analysis of randomized controlled trials
  19. 19
    “…OBJECTIVES: To examine the association between β-blocker prescription and first primary-care consultation for knee OA, hip OA, knee pain and hip pain. METHODS: Data source: Clinical Practice Research Datalink. …”
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    β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score–matched cohort study
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    “…OBJECTIVES: To explore clustering of comorbidities among patients with a new diagnosis of OA and estimate the 10-year mortality risk for each identified cluster. …”
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    Classification of patients with osteoarthritis through clusters of comorbidities using 633 330 individuals from Spain
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