Mostrando 1 - 19 Resultados de 19 Para Buscar '"The Messengers"', tiempo de consulta: 0.80s Limitar resultados
  1. 1
    “…Exosomes are regarded as extracellular messengers that transfer ncRNAs between neurons and body fluids due to their ability to cross the blood-brain barrier. …”
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    Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications
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    “…Over the past two decades, significant technological innovations have led to messenger RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic vaccines, protein replacement therapies, and genome engineering. …”
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    mRNA-Based Therapeutics in Cancer Treatment
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    “…Clinical trials of siRNA- and miRNA-based drugs have already been initiated. siRNAs and miRNAs share many similarities, both are short duplex RNA molecules that exert gene silencing effects at the post-transcriptional level by targeting messenger RNA (mRNA), yet their mechanisms of action and clinical applications are distinct. …”
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    siRNA Versus miRNA as Therapeutics for Gene Silencing
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    “…Results showed that both messenger RNA and protein levels of GEF-H1 were significantly higher in high-grade melanomas. …”
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    Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
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    “…We found that OsPPR16 is responsible for a single editing event at position 545 in the chloroplast rpoB messenger RNA (mRNA), resulting in an amino acid change from serine to leucine in the β‐subunit of the PEP. …”
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    Accumulation of the RNA polymerase subunit RpoB depends on RNA editing by OsPPR16 and affects chloroplast development during early leaf development in rice
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    “…The use of messenger RNA (mRNA) enables the transient production of therapeutic proteins with stable and predictable translational kinetics and without the risk of insertional mutagenesis. …”
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    Chemically modified in-vitro-transcribed mRNA encoding thrombopoietin stimulates thrombopoiesis in mice
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    “…N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNA, and involved in various biological processes in plants. …”
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    Transcriptome-wide m6A methylation in natural yellow leaf of Catalpa fargesii
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    “…N(6)-methyladenosine (m(6)A), the most prevalent internal RNA modification on mammalian messenger RNAs (mRNAs), regulates fates and functions of modified transcripts through m(6)A-specific binding proteins(1–5). m(6)A is abundant in the nervous system and modulates various neural functions(6–11). …”
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    m(6)A facilitates hippocampus-dependent learning and memory through Ythdf1
  9. 9
    por Cao, Jiangang, Zhang, Yu, Wang, Tianyi, Li, Bo
    Publicado 2018
    “…Chondrocytes from patients with OA were subjected to H(2)O(2) treatment with or without baicalin pretreatment, and cell viability was assessed via Cell Counting Kit-8. Messenger RNA (mRNA) amounts of apoptosis-related genes (Bax, Bcl-2, and Caspase-3), extracellular matrix (ECM)-related genes (Collange I, Collange II, Aggrecan, and Sox9) and ER stress hallmarks (binding immunoglobulin protein [BiP] C/EBP homologous protein [CHOP]) were evaluated via quantitative real-time PCR. …”
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    Endoplasmic Reticulum Stress Is Involved in Baicalin Protection on Chondrocytes From Patients With Osteoarthritis
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    “…Spontaneous beating rate of isolated (ie, denervated) sinus node (SN) preparations exhibited a day-night rhythm concomitant with rhythmic messenger RNA expression of ion channels including hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4). …”
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    A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate
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    “…RESULTS: PPL expression in OV tissues was higher than that in normal ovarian tissues (P<0.05). PPL messenger RNA (mRNA) expression was highest in the OV cell line CAOV-4 and lowest in the OV cell line CoC1. …”
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    Mechanism of periplakin on ovarian cancer cell phenotype and its influence on prognosis
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    “…Moreover, 72-SDC could raise c-Kit, stem cell factor (SCF), glial cell-derived neurotrophic factor (GNDF), neuronal nitric oxide synthase (nNOS), and endothelial nitric oxide synthase (eNOS) messenger RNA (mRNA) and protein expression levels, and reduce transient receptor potential cation channel subfamily V member 1 (TRPV1) and inducible nitric oxide synthase (iNOS) expression levels in small-intestinal tissue compared to the levels in the control group. …”
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    Preventive Effects of Different Fermentation Times of Shuidouchi on Diphenoxylate-Induced Constipation in Mice
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    “…This study was to construct a new multi-RNA-based model to predict the recurrence and prognosis for OvCa patients by using the messenger RNA (mRNA, including long noncoding RNA (lncRNA)) and microRNA (miRNA) sequencing data of The Cancer Genome Atlas database. …”
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    Recurrence-Associated Multi-RNA Signature to Predict Disease-Free Survival for Ovarian Cancer Patients
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    “…Poly(A) tails at the 3’ end of eukaryotic messenger RNAs control mRNA stability and translation efficiency. …”
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    Poly(A)-seq: A method for direct sequencing and analysis of the transcriptomic poly(A)-tails
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    “…The histological hematoxylin-and-eosin (H&E) staining results indicated that eumelanin amounts were absent in hair follicles of MC1R-knockout (KO) rabbits, when compared with that of donor BR. In addition, the messenger RNA (mRNA) levels of some key downstream genes in the MC1R pathway were all downregulated in MC1R-KO rabbits compared with BR and YR. …”
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    A Novel Pale-Yellow Coat Color of Rabbits Generated via MC1R Mutation With CRISPR/Cas9 System
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    “…This study aimed to explore the association between immune-related lncRNA-microRNA (miRNA)-messenger RNA (mRNA)-ceRNA networks, and the prognosis of and immunotherapy response in lung adenocarcinoma. …”
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    A novel immune-related ceRNA network that predicts prognosis and immunotherapy response in lung adenocarcinoma
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    “…In addition, the five-gene messenger RNA (mRNA) and protein expression were overexpressed in HCC cells and tissues. …”
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    Glycosylation-related molecular subtypes and risk score of hepatocellular carcinoma: Novel insights to clinical decision-making
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    “…Similarly, cytokines were also detected by quantitative PCR (qPCR) in the messenger RNA (mRNA) levels, and the results were consistent with the enzyme-linked immunosorbent assay (ELISA) kits. …”
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    Protective Effects of Bacillus amyloliquefaciens 40 Against Clostridium perfringens Infection in Mice
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    “…METHODS: Based on the interactions among long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and messenger RNAs (mRNAs), a ceRNA network was constructed to illustrate the relationships among lncRNAs, miRNAs, and mRNAs. …”
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    Ferroptosis-related gene SLC1A5 is a novel prognostic biomarker and correlates with immune infiltrates in stomach adenocarcinoma
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