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2por You, Yuyan, Bai, Chao, Liu, Xuefeng, Xia, Maohua, Yin, Yanqiang, Chen, Yucun, Wang, Wei, Jia, Ting, Lu, Yan, Pu, Tianchun, Zhang, Chenglin, Li, Xiaoguang, Wang, Liqin, Xiu, Yunfang, Niu, Lili, Zhou, Jun, Du, Yang, Liu, Yanhui, Xu, Suhui“…The mutation was not found in 13 unaffected unrelated animals but was found in an unrelated animal also diagnosed with senile congenital cataract. …”
Publicado 2021
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3por Hakimizadeh, Elham, Kaeidi, Ayat, Taghipour, Zahra, Mehrzadi, Saeed, Allahtavakoli, Mohammad, Shamsizadeh, Ali, Bazmandegan, Gholamreza, Hassanshahi, Jalal, Aflatoonian, Mohammad Reza, Fatemi, ImanEnlace del recurso
Publicado 2020
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4“…Adult SPF female Wistar rats were selected to establish a bilateral ovariectomized animal model (OVX), which simulated senile vaginitis dominated by estrogen deficiency in ovarian dysfunction. …”
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5por Balthazar, Janaina, Schöwe, Natalia Mendes, Cipolli, Gabriela Cabett, Buck, Hudson Sousa, Viel, Tania Araujo“…The TG-EE group presented improved spatial memory when compared to the TG-Ctrl animals. In addition, the TG-EE group showed a 69.2% reduction in the total density of senile plaques in the hippocampus when compared to the TG-Ctrl group. …”
Publicado 2018
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6por Servín‐Casas, Gabriela Andrea, Romo‐Araiza, Alejandra, Gutierrez‐Salmean, Gabriela, Martinez‐Solis, Enrique, Ibarra‐García, Andrea Paola, Cruz‐Martinez, Yolanda, Rodriguez‐Barrera, Roxana, García, Elisa, Incontri‐Abraham, Diego, Ibarra, Antonio“…AIMS: We correlated the levels of GLP‐1 with spatial memory in senile animals to determine its role in memory improvement after prebiotic and probiotic supplementation. …”
Publicado 2022
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7“…Gut microbiota (GM) could regulate the bone metabolic process and be closely related to senile osteoporosis. Several genus-level GM were found to increase in osteoporotic animals and patients. …”
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8por Reglodi, Dora, Jungling, Adel, Longuespée, Rémi, Kriegsmann, Joerg, Casadonte, Rita, Kriegsmann, Mark, Juhasz, Tamas, Bardosi, Sebastian, Tamas, Andrea, Fulop, Balazs Daniel, Kovacs, Krisztina, Nagy, Zsuzsanna, Sparks, Jason, Miseta, Attila, Mazzucchelli, Gabriel, Hashimoto, Hitoshi, Bardosi, Attila“…We hypothesized that the progressive decline of PACAP throughout life and the well‐known general cytoprotective effects of PACAP lead to age‐related pathophysiological changes in PACAP deficiency, supported by the increased vulnerability to various stressors of animals partially or totally lacking PACAP. Using young and aging CD1 PACAP knockout (KO) and wild type (WT) mice, we demonstrated pre‐senile amyloidosis in young PACAP KO animals and showed that senile amyloidosis appeared accelerated, more generalized, more severe, and affected more individuals. …”
Publicado 2018
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9por Trumbore, Conrad N.“…Human and animal model studies report that senile plaques contain a halo of AβO molecules surrounding these plaques. …”
Publicado 2018
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10por Si, Yanna, Zhang, Yuan, Han, Liu, Chen, Lihai, Xu, Yajie, Sun, Fan, Ji, Muhuo, Yang, Jianjun, Bao, Hongguang“…BACKGROUND: Previous studies showed that isoflurane-induced cognitive deficits could be alleviated by dexmedetomidine in young animal subjects. In the current study, we examine whether dexmedetomidine could also alleviate isoflurane-induced cognitive deficits in senile animals. …”
Publicado 2016
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11por Ramos-Rodriguez, Juan Jose, Molina-Gil, Sara, Rey-Brea, Raquel, Berrocoso, Esther, Garcia-Alloza, Monica“…Altogether our data suggest that serotonergic denervation may interfere with some pathological aspects observed in AD, including tau phosphorylation or cognitive impairment, without affecting Aβ pathology, supporting a differential role of specific neurotransmitter systems in AD.…”
Publicado 2013
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12por Chambers, James K., Tokuda, Takahiko, Uchida, Kazuyuki, Ishii, Ryotaro, Tatebe, Harutsugu, Takahashi, Erika, Tomiyama, Takami, Une, Yumi, Nakayama, Hiroyuki“…Although many animal species develop senile plaques (SP) composed of amyloid-β (Aβ) proteins that are identical to those found in humans, none of them exhibit neurofibrillary tangles (NFT) and subsequent neurodegeneration, which are integral parts of the pathology of AD. …”
Publicado 2015
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13por Zhang, Kewen, Qiu, Wuxia, Li, Hui, Li, Jun, Wang, Pai, Chen, Zhihao, Lin, Xiao, Qian, AirongEnlace del recurso
Publicado 2023
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14por Ito, Koichi“…A model animal showing spontaneous onset is a useful tool for investigating the mechanism of disease. …”
Publicado 2013
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15“…Clinically, a diagnosis remains a postmortem one, hampering both accurate and early diagnosis as well as research into potential new treatments. …”
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16“…The appearance of Aβ (amyloid β-peptide) depositions at 12 months of age did not trigger astroglial hypertrophy; nor did it result in the close association of astrocytes with senile plaques. …”
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17por Alvites, Rui, Caine, Abby, Cherubini, Giunio Bruto, Prada, Justina, Varejão, Artur Severo P., Maurício, Ana Colette“…However, greater difficulty in quantitatively assessing olfactory acuity in animals and a manifestly smaller number of studies dedicated to this topic maintain a lack of concrete and unequivocal results in this field of veterinary sciences. …”
Publicado 2023
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18“…The average life span steadily grows in humans and in animals kept as pets or left in sanctuaries making the issue of elderly-associated cognitive impairment a hot-spot for scientists. …”
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19“…Given the prevalence and poor prognosis of the disease, the development of animal models has been a research priority to understand pathogenic mechanisms and to test therapeutic strategies. …”
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20por Zhao, Fei-Yi, Fu, Qiang-Qiang, Zheng, Zhen, Lao, Li-Xing, Song, Hua-Ling, Shi, Zumin“…BACKGROUND: Alzheimer's disease (AD) is a common health condition affecting senile people and leads to severe cognitive dysfunctions. …”
Publicado 2020
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