-
1“…The results demonstrated that the prototype ARCHITECT assay is more sensitive in detecting HBsAg in the presence of anti-HBs than current HBsAg assays. …”
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Online Artykuł Texto -
2od Holzmayer, Vera, Taylor, Russell, Kuhns, Mary C., Gawel, Susan H., Ndembi, Nicaise, Mbanya, Dora, Kaptue, Lazare, Rodgers, Mary A., Cloherty, Gavin“…We evaluated the use of DBS whole blood samples in the modified Abbott ARCHITECT anti-HCV assay, comparing assay performance against the standard assay run using DBS and venous plasma samples. 144 HCV positive and 104 HCV negative matched venous plasma and whole blood specimens were selected from a retrospective study with convenience sampling in Cameroon. …”
Wydane 2022
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Online Artykuł Texto -
3od Rodgers, Mary A., Shah, Pir A., Anderson, Mark, Vallari, Ana S., Gersch, Jeffrey, Mbanya, Dora, Sauleda Oliveras, Silvia, Choudhry, Saad, Leary, Thomas P., Kuhns, Mary C., Dawson, George J., Cloherty, Gavin A., Lau, Daryl T.Y.“…To evaluate the clinical utility of HBsAg isoforms, we developed novel prototype assays on the ARCHITECT automated serology platform that specifically detects total-HBsAg (T-HBsAg), large (L-HBsAg), and middle (M-HBsAg) products of the S gene to determine the isoform composition of human specimens from acute and chronic HBV infection and during long-term nucleos(t)ide analog therapy. …”
Wydane 2023
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Online Artykuł Texto -
4Development and performance of prototype serologic and molecular tests for hepatitis delta infectionod Coller, Kelly E., Butler, Emily K., Luk, Ka-Cheung, Rodgers, Mary A., Cassidy, Michael, Gersch, Jeffrey, McNamara, Anne L., Kuhns, Mary C., Dawson, George J., Kaptue, Lazare, Bremer, Birgit, Wedemeyer, Heiner, Cloherty, Gavin A.“…Prototype molecular (RNA) and serologic (IgG) assays were developed for high-throughput testing on the Abbott m2000 and ARCHITECT systems, respectively. RNA detection was achieved through amplification of a ribozyme region target, with a limit of detection of 5 IU/ml. …”
Wydane 2018
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Online Artykuł Texto -
5od Bazinet, Michel, Pântea, Victor, Cebotarescu, Valentin, Cojuhari, Lilia, Jimbei, Pavlina, Anderson, Mark, Gersch, Jeff, Holzmayer, Vera, Elsner, Carina, Krawczyk, Adalbert, Kuhns, Mary C., Cloherty, Gavin, Dittmer, Ulf, Vaillant, Andrew“…Supplemental analysis included high‐sensitivity HBsAg (Abbott ARCHITECT HBsAg NEXT), HBV pregenomic RNA (pgRNA), HBsAg/hepatitis B surface antibody (anti‐HBs) immune complexes (HBsAg ICs), and hepatitis B core‐related antigen (HBcrAg). …”
Wydane 2020
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Online Artykuł Texto -
6od Kuhns, Mary C., Holzmayer, Vera, Anderson, Mark, McNamara, Anne L., Sauleda, Silvia, Mbanya, Dora, Duong, Pham T., Dung, Nguyen T. T., Cloherty, Gavin A.“…Methods: A total of 347 samples collected from the USA, South Africa, Spain, Cameroon, Vietnam, and Cote D’Ivoire representing NAT yield (HBsAg(−), antibody to HBV core antigen (anti-HBc)(−), HBV DNA(+), N = 131), OBI (HBsAg(−), anti-HBc(+), HBV DNA(+), N = 188), and HSLD (HBsAg(+), anti-HBc(+), HBV DNA(+), N = 28) were tested with ARCHITECT HBsAg NEXT (HBsAgNx) (sensitivity 0.005 IU/mL). …”
Wydane 2021
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Online Artykuł Texto -
7od Kuhns, Mary C., Holzmayer, Vera, McNamara, Anne L., Anderson, Mark, Cloherty, Gavin A.“…Testing included quantitative hepatitis B surface antigen (HBsAg), antibodies to HBV antigens, quantitative HBV e antigen (HBeAg), HBV DNA, quantitative HBV core-related antigen (HBcrAg), the highly sensitive ARCHITECT HBsAg NEXT (HBsAgNx) assay, and a quantitative research assay for HBV pregenomic RNA (pg RNA). …”
Wydane 2021
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe
Online Artykuł Texto