Pharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells through SAMHD1 Modulation

por Resop, Rachel S., Bosque, Alberto
Publicado 2022

Porcine Epidemic Diarrhea Virus Infection Disrupts the Nasal Endothelial Barrier To Favor Viral Dissemination

por Li, Jianda, Li, Yuchen, Liu, Peng, Wang, Xiuyu, Ma, Yichao, Zhong, Qiu, Yang, Qian
Publicado 2022

Vesicular Stomatitis Virus-Based Epstein-Barr Virus Vaccines Elicit Strong Protective Immune Responses

por Kong, Xiang-Wei, Zhang, Xiao, Bu, Guo-Long, Xu, Hui-Qin, Kang, Yin-Feng, Sun, Cong, Zhu, Qian-Ying, Ma, Run-Bo, Liu, Zheng, Zeng, Yi-Xin, Zeng, Mu-Sheng, Hu, Zhu-Long
Publicado 2022

Zika Virus Induces Mitotic Catastrophe in Human Neural Progenitors by Triggering Unscheduled Mitotic Entry in the Presence of DNA Damage While Functionally Depleting Nuclear PNKP

por Rychlowska, Malgorzata, Agyapong, Abigail, Weinfeld, Michael, Schang, Luis M.
Publicado 2022

Genomic Screening of Antimicrobial Resistance Markers in UK and US Campylobacter Isolates Highlights Stability of Resistance over an 18-Year Period

por van Vliet, Arnoud H. M., Thakur, Siddhartha, Prada, Joaquin M., Mehat, Jai W., La Ragione, Roberto M.
Publicado 2022

Glby, Encoded by MAB_3167c, Is Required for In Vivo Growth of Mycobacteroides abscessus and Exhibits Mild β-Lactamase Activity

por Galanis, Christos, Maggioncalda, Emily C., Kumar, Pankaj, Lamichhane, Gyanu
Publicado 2022

Effectiveness of Nifurtimox in the Treatment of Chagas Disease: a Long-Term Retrospective Cohort Study in Children and Adults

por Falk, N., Berenstein, A. J., Moscatelli, G., Moroni, S., González, N., Ballering, G., Freilij, H., Altcheh, J.
Publicado 2022

Forgiveness of INSTI-Containing Regimens at Drug Concentrations Simulating Variable Adherence In Vitro

por Acosta, Rima K., D’Antoni, Michelle L., Mulato, Andrew, Yant, Stephen R., Cihlar, Tomas, White, Kirsten L.
Publicado 2022

Selective Inhibition of Plasmodium falciparum ATPase 6 by Artemisinins and Identification of New Classes of Inhibitors after Expression in Yeast

por Moore, Catherine M., Wang, Jigang, Lin, Qingsong, Ferreira, Pedro, Avery, Mitchell A., Elokely, Khaled, Staines, Henry M., Krishna, Sanjeev
Publicado 2022

The Consistent Tick-Vertebrate Infectious Cycle of the Lyme Disease Spirochete Enables Borrelia burgdorferi To Control Protein Expression by Monitoring Its Physiological Status

por Stevenson, Brian, Krusenstjerna, Andrew C., Castro-Padovani, Tatiana N., Savage, Christina R., Jutras, Brandon L., Saylor, Timothy C.
Publicado 2022

In Vitro Activity of Ertapenem against Neisseria gonorrhoeae Clinical Isolates with Decreased Susceptibility or Resistance to Extended-Spectrum Cephalosporins in Nanjing, China (20...

por Li, Xuechun, Le, Wenjing, Lou, Xiangdi, Genco, Caroline A., Rice, Peter A., Su, Xiaohong
Publicado 2022

Pseudomonas aeruginosa Initiates a Rapid and Specific Transcriptional Response during Surface Attachment

por Jones, Christopher J., Grotewold, Nikolas, Wozniak, Daniel J., Gloag, Erin S.
Publicado 2022

Phage Infection Restores PQS Signaling and Enhances Growth of a Pseudomonas aeruginosa lasI Quorum-Sensing Mutant

por Høyland-Kroghsbo, Nina Molin, Bassler, Bonnie L.
Publicado 2022

Preclinical Data on the Gardnerella-Specific Endolysin PM-477 Indicate Its Potential to Improve the Treatment of Bacterial Vaginosis through Enhanced Biofilm Removal and Avoidance...

por Landlinger, Christine, Oberbauer, Vera, Podpera Tisakova, Lenka, Schwebs, Timo, Berdaguer, Rocío, Van Simaey, Leen, Vaneechoutte, Mario, Corsini, Lorenzo
Publicado 2022

Pharmacokinetics of Oral Tebipenem Pivoxil Hydrobromide in Subjects with Various Degrees of Renal Impairment

por Patel, Gina, Rodvold, Keith A., Gupta, Vipul K., Bruss, Jon, Gasink, Leanne, Bajraktari, Floni, Lei, Yang, Jain, Akash, Srivastava, Praveen, Talley, Angela K.
Publicado 2022

Exposure–Efficacy Analyses Support Optimal Dosing Regimens of Ceftolozane/Tazobactam in Participants with Hospital-Acquired/Ventilator-Associated Bacterial Pneumonia in ASPECT-NP

por Gao, Wei, Passarell, Julie, Patel, Yogesh T., Zhang, Zufei, Lin, Gina, Fiedler-Kelly, Jill, Bruno, Christopher J., Rhee, Elizabeth G., De Anda, Carisa S., Feng, Hwa-Ping
Publicado 2022

Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA

por Jacobs, Holly M., O’Neal, Lindsey, Lopatto, Edward, Wozniak, Daniel J., Bjarnsholt, Thomas, Parsek, Matthew R.
Publicado 2022

Population Pharmacokinetics of Antimalarial Naphthoquine in Combination with Artemisinin in Tanzanian Children and Adults: Dose Optimization

por Ali, Ali Mohamed, Gausi, Kamunkhwala, Jongo, Said A., Kassim, Kamaka R., Mkindi, Catherine, Simon, Beatus, Mtoro, Ali T., Juma, Omar A., Lweno, Omar N., Gwandu, Conrad H., Bakari, Bakari M., Mbaga, Thabiti A., Milando, Florence A., Hamad, Ali, Shekalaghe, Seif A., Abdulla, Salim, Denti, Paolo, Penny, Melissa A.
Publicado 2022

Making Antimicrobial Susceptibility Testing More Physiologically Relevant with Bicarbonate?

por Hinnu, Mariliis, Putrinš, Marta, Kogermann, Karin, Bumann, Dirk, Tenson, Tanel
Publicado 2022

Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020

por Prasad, Neha K., Seiple, Ian B., Cirz, Ryan T., Rosenberg, Oren S.
Publicado 2022