“…As an example, we use the mu-opioid receptor (µ-OR), a prototypic class A GPCR, and its active state sensor, nanobody-39 (Nb39). We demonstrate that ligands vary in their ability to recruit Nb39 to µ-OR and describe methadone, loperamide, and PZM21 as ligands that support unique R* conformation(s) of µ-OR. …”
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“…Mutations were introduced in its protease domain, Pro39, and the mutated proteins were expressed in Escherichia coli, purified and their activity in vitro was compared to that of the wild type Pro39. …”
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“…Multiple E3 ubiquitin ligase genes, including tripartite motif 10 (TRIM10), TRIM15, TRIM26, TRIM27, TRIM31, TRIM38, TRIM39, TRIM40, and RING finger protein 39 (RNF39), are organized in a tight cluster, and an additional two TRIM genes (namely TRIM38 and TRIM27) telomeric of the cluster within the MHC-I region. …”
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“…We carried out a case study with a group of female victims of gender violence (n = 39) with the objective of evaluating a blended psychotherapeutic intervention. …”
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“…In vivo, Fkbp39 binding directs the translocation of nascent 60S subunits toward the nucleophosmin-rich granular component. …”
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“…MAIN OUTCOME MEASURES: eGFRs and hazard ratios of composite adverse outcome (all cause mortality, any cardiovascular event, and kidney failure) stratified by age (18-39 years, 40-49 years, and 50-65 years), and relative to age specific eGFR referents (100-110 mL/min/1.73m(2)) for ages 18-39 years, 90-100 for 40-49 years, 80-90 for 50-65 years). …”
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“…In the unvaccinated group, the percentages of specimens with any measurable PRNT(50) versus wild type or VOC were wild-type SARS-CoV-2 (16/39 [41%]), Alpha (16/39 [41%]), Beta (10/39 [26%]), Gamma (9/39 [23%]), Delta (16/39 [41%]), and Omicron BA.1 (0/39) (Fisher's exact tests, vaccinated versus unvaccinated for each variant, P < 0.05). …”
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“…The 10 most upregulated tRFs and tsRNAs were tRF‐39‐I6D3887S1RMH5MI2, tRF‐21‐2E489B3RB, tRF‐18‐JMRPFQDY, tRF‐17‐202L2YF, tRF‐17‐VBY9PYJ, tRF‐18‐YRRHQFD2, tRF‐21‐WE884U1DD, tRF‐41‐EX2Z10I9BZBZOS4YB, tRF‐39‐HPDEXK7S1RNS9MI2, and tRF‐20‐1SS2P46I. …”
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“…Mechanistically, exosomal circTMEM181 sponged miR-488-3p and upregulated CD39 expression in macrophages. Using macrophage-specific CD39 knockout mice and pharmacologic approaches, we revealed a novel mode of anti-PD1 resistance in HCC. …”
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“…VM was mainly used for teaching pathology courses (25/39) at medical schools (30/39). Dental schools (10/39) have also reported using VM for teaching microscopy. …”
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“…New phase for Openlab 00 :00 -00 :11 : titres 00 :12 -00 : 38 : logo Openlab + footage CERN computing centre 00 :39- 01 :38 : interview of Bob Jones Head of CERN openlab 01 :39 – 01 :55 : footage computing centre 01 :56- 03 :09 : interview of Sverre Jarp , CERN openlab Chief Technology Officer 03 :10-04 :02 : footage technical rack computing centre 04 :03- 04 :56 : second interview of Sverre Jarp about éducation 04 :57- 05 :58 : interview of Andrzej Nowak staff researcher of CERN openlab 05 :59- END : others footage of computing center…”
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“…The 39 papers are grouped into the following sections: - Applications of Microscopy in the Physical Sciences - Applications of Microscopy in the Biological Sciences…”
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“…We compared the characteristics and pregnancy outcomes in NGT women according to different groups [(<3.9mmol/L), (3.9-4.2mmol/L), (4.25-4.4mmol/L) and (>4.4mmol/L)] of lowest glycemia measured during the OGTT. …”
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“…CONCLUSIONS: Molecular signatures consisting of five genes (PGR, GABRP, TBC1D9, SLC39A6 and LRBA) for disease mortality and of six genes (PGR, ESR1, GABRP, TBC1D9, SLC39A6 and LRBA) for disease recurrence were identified. …”
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“…Incidence of treatment-emergent antidrug antibodies was similar to placebo (3.9%, 4.8%, 3.9%). No deaths or new/unexpected safety findings were reported. …”
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“…The number of unigenes found for the three biological replications were 39,726, 40,440 and 41,626 for CsPT-CK; 36,993, 39,070 and 39,439 for CsPT-LT; and 39,514, 38,298 and 39,061 for CsPT-NO. …”
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