“…The postcourse feedback questionnaire indicated that VSP-TCM can better enhance students’ TCM thinking ability (n=39, 93%, vs n=37, 88%; P=.002), medical history collection (n=38, 90%, vs n=30, 72; P=.001), syndrome differentiation and treatment and critical thinking (n=38, 90%, vs n=37, 88%; P=.046), comprehensive clinical application ability (n=40, 95%, vs n=36, 86%; P=.009), interpersonal communication skills (n=36, 86%, vs n=28, 67%; P=.01), and autonomous learning ability (n=37, 88%, vs n=28, 67%; P=.01) than traditional academic training. …”
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“…Plasma from a cohort of Roux-en-Y bariatric surgery (n=50) and non-surgery (n=76) comparator-subjects-with-obesity (both cohorts at 12-year follow-up) plus a normal-weight cohort (n=39) was assayed by Luminex immunoassay or ELISA for hepatokines [angiopoietin-like proteins-(ANGPTL3; ANGPTL4; ANGPTL6); fibroblast growth factors-(FGF19; FGF21; FGF23)]; adipokines [adipsin; adiponectin; FGF19] and myonectin. …”
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“…At histological examination, Ki-67 was <1.5% in 17 cases (39.5%). The SSTR2A Volante scores were 0-1 in 5 cases (11.6%) and 2-3 in 38 cases (88.4%). …”
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“…At baseline 94 (46.3%) had normal level of visceral fat, 80 (39.4%) had high and 29 (14.3%) had very high level of visceral fat. …”
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“…Results: 192 patients (median age 54.5 (39.8-67.0) years with 54.2% female) were included. …”
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“…The proportion of patients with low TBS was similar between the two groups (39.86% vs 41.83%; p=0.727). The BMD at lumbar spine (LS) [0.977 (0.877-1.128) vs 0.945 (0.814-1.148) g/cm(2); p=0.219] and distal forearm (FA) [0.689 (0.618-0.736) vs 0.661 (0.576-0.731) g/cm(2); p = 0.053] were also comparable between the two groups. …”
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“…Testosterone concentrations were lower for men who: were married/de facto (-0.57 nmol/L); undertook ≤75 minutes vigorous physical activity/week (-0.51 nmol/L); former smokers (-0.34 nmol/L); had hypertension (-0.53 nmol/L), cardiovascular disease (-0.35 nmol/L), cancer (-1.39 nmol/L), or diabetes (-1.43 nmol/L); all CIs excluded zero. …”
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“…In children with isolated SS, 5 children had more than one causative finding. There were 39 defects associated with the growth plate [SHOX (n=13); NPR2 (n=7); IHH (n=10); ACAN (n=5); FGFR3 (n=3); COL2A1 (n=1)], 6 involved in the GH-IGF-1 axis [GHSR (n=3); IGF1R (n=2); GH1 (n=1)], 9 related to the RAS/MAPK pathway [PTPN11 (n=4); NF1 (n=3); BRAF (n=1); CBL (n=1)]; and 17 other genes [LTBP3 (n=2); THRA (n=2); TYMP; PIK3CA; CDKN1C; ANKRD11; HMGA2; SRCAP; KMT2C; GDF5; OBSL1; MC4R; FBN1; PRKG2; ERF (one patient each)]. …”
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“…In patients with T1D and T2D, liver enzymes were on average elevated with respective ALT 49.5±58.1 and 46.3±40.2 (</=33) U/L, AST 42.3±49.4 SD and 41.6±28.8 (</=32) U/L, ALP 115.1±39.9 and 92.9±42.3 (35-104) U/L. One patient with T1D (9%) and 78 (47%) patients with T2D developed cirrhosis. …”
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“…Cirrhosis was observed in 10% of the participants, with age of onset 39 ± 13 years. We observed a high incidence of depression and anxiety (47 and 45%) from medical history evaluation. …”
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“…Nine (16%) patients had hypogonadism (median [IQR] age of diagnosis 37.4 [35.7,39.0] years), six of whom were on testosterone replacement. …”
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“…Reductions in HbA1c were slightly greater in GADA-negative patients (estimated treatment differences [95% confidence interval]: 0.21% [0.03, 0.39]; p=0.024), whereas reductions in body weight did not significantly differ between groups (0.38 kg [-0.99, 1.75]; p=0.588). …”
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“…In addition, in the distal airways there were significant acute effects at TLC on mean siV(aw) and siR(aw) (siV(aw): 39.8% and 62.6%; siR(aw): − 51.1% and − 57.2%, V2 and V3, respectively; all p < 0.001) and at FRC at V2 (siV(aw): 77.9%; siR(aw): − 67.0%; both p < 0.001). …”
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“…Evidence for the protection of the booster dose was detected among young adults aged 18–39 years, but was not detected for those aged 40 years or older. …”
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“…The top four and five tasks were contact with patients or health services (39.6%) and referral (16.6%) in nurses. Most CHWs had received primary and common diseases-related trainings, but they had few opportunities to study in a tertiary hospital (40.4% in doctors and 20.9% in nurses, respectively), attend domestic academic conferences (26.9% in doctors vs. 9.7% in nurses), and take part in training courses (44.9% in nurses). …”
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“…The objective response rate (ORR) of patients in the combination therapy and chemotherapy alone groups was 39.5% (51/129) vs. 27.5% (22/80), and the disease control rate (DCR) between the two groups was 89.9% (116/129) vs. 83.8% (67/80). …”
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“…Long-term O(3) exposure was independently, positively and non-linearly associated with incident hypertension (Hazard ratios (95% CI) for Q2, Q3, and Q4 were 1.77 (1.34, 2.36), 2.06 (1.42, 3.00) and 3.43 (2.46, 4.79), respectively, as compared with the first quartile (Q1)), DBP (β (95% CI) was 0.65 (0.01, 1.30) for Q2, as compared to Q1), SBP (β (95% CI) was 2.88 (2.00, 3.77), 2.49 (1.36, 3.61) and 2.61 (1.64, 3.58) for Q2, Q3, and Q4, respectively), PP (β (95% CI) was 2.12 (1.36, 2.87), 2.03 (1.18, 2.87) and 2.14 (1.38, 2.90) for Q2, Q3, and Q4, respectively), and MAP (β (95% CI) was 1.39 (0.76, 2.02), 1.04 (0.24, 1.84) and 1.12 (0.43, 1.82) for Q2, Q3, and Q4, respectively). …”
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“…OBJECTIVE: YKL-40, also known as chitinase-3-like-1 (CHI3L1), is a human cartilage glycoprotein-39, with its N-terminus consisting of tyrosine (Y), lysine (K), and leucine (L), hence the name YKL-40. …”
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“…In total, 232 patients (24.3%) reported at least one adverse drug reaction, and most events were mild; eight patients (3.9%) in the RA cohort experienced nine serious adverse events (SAEs; two possibly related to SB5); eight patients (4.9%) in the PsA cohort experienced nine SAEs (one possibly related to SB5); 22 patients (4.9%) in the CD cohort experienced 27 SAEs (four possibly related to SB5); and no SAEs were observed in the UC cohort. …”
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“…In all patients, respiratory effort increased from NRB to Helmet-CPAP (5.0 ± 3.7 vs 8.3 ± 3.9 cmH(2)O, p < 0.01). However, Helmet’s pressure decreased by a comparable amount during inspiration (− 3.1 ± 1.0 cmH(2)O, p = 0.16), therefore dynamic stress remained stable (p = 0.97). …”
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