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  1. 173241
    “…METHODS: Eighteen broilers were sacrificed after exposure to one of the following gas mixtures for 90 s: 40% CO(2) + 21% O(2) + 39% N(2) (G40%), 79% CO(2) + 21% O(2) (G79%), or no stunning (0% CO(2), control). …”
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    Gas stunning with CO(2) affected meat color, lipid peroxidation, oxidative stress, and gene expression of mitogen-activated protein kinases, glutathione S-transferases, and Cu/Zn-superoxide dismutase in the skeletal muscles of broilers
  2. 173242
    “…Overall, 34,857 ART-naïve patients (39.1% male, median age 34 years [IQR 28–41], median CD4 268 cells/μL [IQR 134–430]) newly enrolled in HIV care during this period; 23,036 were analyzed after excluding patients around the threshold to allow for clinic-to-clinic variations in actual guideline uptake. …”
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    Estimating the real-world effects of expanding antiretroviral treatment eligibility: Evidence from a regression discontinuity analysis in Zambia
  3. 173243
    “…We do not know if ribavirin reduces the length of stay in hospital (1 RCT: mean difference (MD) 0.70 days, 95% CI ‐0.39 to 1.79; 136 participants; and 1 non‐randomized study: MD ‐0.80, 95% CI ‐2.70 to 1.10; 50 participants; very low‐certainty evidence). …”
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    Ribavirin for treating Crimean Congo haemorrhagic fever
  4. 173244
    Publicado 2011
    “…The 1, 3, 5 and 10 year survival rates of the 516 cases was 89.1%, 39.3%, 19.8% and 10.4%, respectively. The postoperative survival rate was remarkably correlated with micrometastasis in peripheral blood, histological classification of the tumor, size of primary cancer and lymph mode involvement (P < 0.05). …”
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    基于"分子分期"的局部晚期非小细胞肺癌"个体化外科治疗"的长期生存结果
  5. 173245
    “…METHODS: A total of 117 men and postmenopausal women with type 2 diabetes who were taking oral glucose-lowering agents and with HbA(1c) between 47.5 and 63.9 mmol/mol (6.5–8.0%) were randomised after stratification by sex and baseline HbA(1c) in a parallel design to one of three diets for 3 months: (1) ‘full-dose nut diet’ (n = 40): a diet with 2.0 MJ (477 kcal) per 8.4 MJ (2000 kcal) energy provided as mixed nuts (75 g/day); (2) ‘full-dose muffin diet’ (n = 39): a diet with 1.97 MJ (471 kcal) per 8.4 MJ (2000 kcal) energy provided as three whole-wheat muffins (188 g/day), with a similar protein content to the nuts, and the same carbohydrate-derived energy content as the monounsaturated fatty acid-derived energy content in the nuts; or (3) ‘half-dose nut diet’ (n = 38): a diet with 1.98 MJ (474 kcal) per 8.4 MJ (2000 kcal) energy provided as half portions of both the nuts and muffins. …”
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    Nuts as a replacement for carbohydrates in the diabetic diet: a reanalysis of a randomised controlled trial
  6. 173246
    “…Among all treatment groups, only pretreatment with MgAT caused restoration of retinal eNOS expression with a 1.39-fold difference from the NMDA-treated group (p<0.05). eNOS expression in the MgAT pretreatment group was also 1.34-fold higher than in the TAU pretreatment group (p<0.05). …”
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    Protective effect of magnesium acetyltaurate and taurine against NMDA-induced retinal damage involves reduced nitrosative stress
  7. 173247
    “…RESULTS: The mean postoperative NSAs were 133.46° ± 6.01°, 132.39° ± 7.77°, 135.17° ± 10.15°, and 132.41° ± 7.16° in the MCS, MMSS, MSSS, and NMS groups, respectively, and no significant differences were found (F = 1.02, P = 0.387). …”
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    Influence of Medial Support Screws on the Maintenance of Fracture Reduction after Locked Plating of Proximal Humerus Fractures
  8. 173248
    “…With respect to tolerability, amphetamines were inferior to placebo in both children and adolescents (odds ratio [OR] 2·30, 95% CI 1·36–3·89) and adults (3·26, 1·54–6·92); guanfacine was inferior to placebo in children and adolescents only (2·64, 1·20–5·81); and atomoxetine (2·33, 1·28–4·25), methylphenidate (2·39, 1·40–4·08), and modafinil (4·01, 1·42–11·33) were less well tolerated than placebo in adults only. …”
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    Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis
  9. 173249
    “…RESULTS: Compared with healthy individuals, T lymphocyte counts and Th1 cell counts decreased on days 1 and 3 after ROSC (1464 [1198, 2152] vs. 779 [481, 1140] vs. 581 [324, 1118]/μl, χ(2) = 30.342, P < 0.001; 154 [90, 246] vs. 39 [19, 78] vs. 24 [12, 53]/μl, χ(2) = 42.880, P < 0.001), and Th2 and Th17 cell counts decreased on day 3 (17.0 [10.8, 24.0] vs. 9.0 [3.0, 15.5]/μl, Z = –3.228, P = 0.001; 4.7 [2.7, 9.1] vs. 2.7 [1.0, 6.5]/μl, Z = –2.294, P = 0.022). …”
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    Early Changes in Circulatory T Helper Type 1, 2, and 17 Cells of Patients with Out-of-Hospital Cardiac Arrest after Successful Cardiopulmonary Resuscitation
  10. 173250
    “…In negative control MR analyses, later age at menarche was associated with −0.77 kg/m(2) of pre-pubertal BMI measured at age 8 y (or −0.39 SDs, 95% CI −0.50, −0.29; P = 6.28 × 10(−13)), indicating that variants influencing menarche also influence BMI before menarche. …”
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    Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study
  11. 173251
    “…Adding SSB restriction increased gains to approximately 797,900 CVD events prevented, 2.11 million QALYs gained, and $39.16 billion in healthcare costs saved. For SNAP-plus, corresponding gains were approximately 940,000 CVD events prevented, 2.47 million QALYs gained, and $41.93 billion saved. …”
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    Cost-effectiveness of financial incentives and disincentives for improving food purchases and health through the US Supplemental Nutrition Assistance Program (SNAP): A microsimulation study
  12. 173252
    “…The eGFR · LBW and eGFR · BSA products best predicted the ratio of IA to the renal dose (GBq/Gy) for the first cycle (Spearman r = 0.41 and 0.39, respectively; P < 0.001). For the first cycle, the personalized IA proportional to eGFR · LBW or eGFR · BSA decreased the range of delivered renal absorbed dose between patients as compared with the fixed IA. …”
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    Accuracy and reproducibility of simplified QSPECT dosimetry for personalized (177)Lu-octreotate PRRT
  13. 173253
    “…In the human trial, thirty-eight resistance-trained young adults (mean age 26.32 ± 4.39 years, body weight 67.79 ± 12.84 kg, BMI 22.92 ± 3.54 kg/m(2)) completed the trial. …”
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    Combined extracts of Garcinia mangostana fruit rind and Cinnamomum tamala leaf supplementation enhances muscle strength and endurance in resistance trained males
  14. 173254
    por Platts-Mills, James A, Liu, Jie, Rogawski, Elizabeth T, Kabir, Furqan, Lertsethtakarn, Paphavee, Siguas, Mery, Khan, Shaila S, Praharaj, Ira, Murei, Arinao, Nshama, Rosemary, Mujaga, Buliga, Havt, Alexandre, Maciel, Irene A, McMurry, Timothy L, Operario, Darwin J, Taniuchi, Mami, Gratz, Jean, Stroup, Suzanne E, Roberts, James H, Kalam, Adil, Aziz, Fatima, Qureshi, Shahida, Islam, M Ohedul, Sakpaisal, Pimmada, Silapong, Sasikorn, Yori, Pablo P, Rajendiran, Revathi, Benny, Blossom, McGrath, Monica, McCormick, Benjamin J J, Seidman, Jessica C, Lang, Dennis, Gottlieb, Michael, Guerrant, Richard L, Lima, Aldo A M, Leite, Jose Paulo, Samie, Amidou, Bessong, Pascal O, Page, Nicola, Bodhidatta, Ladaporn, Mason, Carl, Shrestha, Sanjaya, Kiwelu, Ireen, Mduma, Estomih R, Iqbal, Najeeha T, Bhutta, Zulfiqar A, Ahmed, Tahmeed, Haque, Rashidul, Kang, Gagandeep, Kosek, Margaret N, Houpt, Eric R
    Publicado 2018
    “…Viral diarrhoea (36·4% of overall incidence, 95% CI 33·6–39·5) was more common than bacterial (25·0%, 23·4–28·4) and parasitic diarrhoea (3·5%, 3·0–5·2). …”
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    Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study
  15. 173255
    “…M72/AS01(E) candidate vaccine is an adjuvanted recombinant fusion protein derived from Mycobacterium tuberculosis Mtb32A and Mtb39A proteins. METHODS: We conducted a randomized, double-blind, placebo-controlled phase 2b trial (NCT01755598) in Southern and Eastern Africa to assess M72/AS01(E)’s efficacy against bacteriologically confirmed pulmonary TB disease in HIV-seronegative (HIV–) adults aged 18–50 years infected with Mtb (defined by a positive IFN-γ release assay). …”
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    120. A Randomized Double-blind Trial Assessing the Efficacy of M72/AS01(E) Vaccine Against Pulmonary Tuberculosis Disease in Adults With Latent Mycobacterium tuberculosis Infection
  16. 173256
    “…Of the 97 positive detections by the BJI panel, 58 were concordant with culture; the 39 additional organism detections were in majority confirmed by PCR/sequencing. …”
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    2290. Identification of Pathogens in Synovial Fluid Samples With an Automated Multiplexed Molecular Detection System
  17. 173257
    “…RSVH and BH were more severe among PT infants in 2014–2016 vs. 2011–2014, with a greater mean LOS (RSVH: 6.8 vs. 4.7 days, P = 0.008; BH: 7.2 vs. 4.6, P = 0.021), a higher proportion of infants admitted to the ICU (RSVH: 42.4% vs. 25.3%, P = 0.014; BH: 39.1% vs. 23.7%, P = 0.009), and increased use of MV (RSVH: 14.1% vs. 6.1%, P = 0.067; BH: 14.8% vs. 5.3%, P = 0.013). …”
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    743. Severity and Costs of Respiratory Syncytial Virus and Bronchiolitis Hospitalization in Commercially Insured Preterm and Term Infants Before and After the 2014 American Academy of Pediatrics Guidance Change on Immunoprophylaxis
  18. 173258
    “…RESULTS: Of the 163 isolates analyzed, 39 sequence types (STs) were identified with ST2 and ST5 isolates being most frequently identified (21% and 20%, respectively). …”
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    1036. Whole Genome Sequencing Analysis of a Large Cohort of Staphylococcus epidermidis Blood Culture Positive Isolates From a Multicenter Clinical Trial
  19. 173259
    “…METHODS: A total of 8,296 GP unique isolates were consecutively collected from 33 United States (n = 4,409) and 39 European (EUR; n = 3,887) medical centers in 2015–2017 and susceptibility tested by reference broth microdilution methods. …”
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    1000. Antimicrobial Susceptibility of Gram-Positive Bacteria Isolated From Patients Hospitalized With Bacteremia in United States and European Medical Centers: Results From the International Dalbavancin Evaluation of Activity (IDEA) Program
  20. 173260
    “…The proportion reporting at least one severe adverse event (Common Terminology Criteria for Adverse Events grade 3 or worse) was similar by treatment group in the safety population (398 [38%] with control and 380 [39%] with radiotherapy). INTERPRETATION: Radiotherapy to the prostate did not improve overall survival for unselected patients with newly diagnosed metastatic prostate cancer. …”
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    Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial
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