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  1. 173641
    “…RESULTS: G1/ARMC5 tumors showed a relative overexpression of the vasopressin receptors AVPR1A and AVPR1B compared to the two other groups (fold-change [FC] =7.39, p<0.001 and 3.98, p<0.001, respectively) but a lower expression of AVPR2 (FC=0.43, p=0.015). …”
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    OR04-3 Genetic Alterations of ARMC5 and KDM1A Are Associated With Different Expression Profiles of Illegitimate Receptors in Primary Bilateral Macronodular Adrenal Hyperplasia
  2. 173642
    “…RESULTS: In WT mice, DHT increased body weight (25.07 ± 0.52 vs 21.79 ± 0.47 g, p<0.05), fat mass (4.60 ± 0.46 vs 1.98 ± 0.12 g, p<0.05), RPF mass (29.68 ± 3.39 vs. 172.64 ± 32.75 g, p<0.05), RPF miR-21 (2.5-fold) and AR expression (2.1-fold). …”
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    RF10 | PMON249 MicroRNA-21 Ablation Exacerbates Androgen-Mediated White Adipose Tissue Dysfunction and Impaired Insulin Signaling in a Mouse Model of Polycystic Ovary Syndrome
  3. 173643
    “…Spontaneous thelarche was reported in 23/58 (39.6%) pubertal patients with mean AMH (0.65ng/mL +/-1.3) compared to absent spontaneous thelarche (N=35, 0.02 +/- 0.04) (p=0.03). …”
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    RF02 | PSAT119 AMH and Spontaneous Puberty in a Diverse US Turner Syndrome Clinic Cohort: A Cross-sectional study
  4. 173644
    “…Recovery of hepatic Mc3r was sufficient to partially reverse the increased percentage fat mass of Mc3rtb/tb (Mc3rtb/tb: n=11, 55.3 ± 0.8% (SEM); Mc3rtb/tb, Alb-Cre+/+: n=13, 52.4 ± 0.8%; BL/6: n=14, 39.7 ± 2.1%, p=0. 017). Similar recovery was observed for total fat mass (p=0. 0012), % lean mass (p=0. 02), and body weight (p=0. 007), with no differences in total lean mass (p=0.1). …”
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    LBODP080 Mc3r Expression In Liver Tissue Is Partially Responsible For The Severity Of Murine MC3R Deficiency Associated Obesity
  5. 173645
    “…Compared to control group, T1D patients demonstrated a homogeneous (PVR, 1.39±0.7 vs 1.46±0.4, p>0.05) decrease of PI (0.6±0.2 vs 1.1±0.3 mL/kg, p<0.0001) independently of pancreatic subregion. …”
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    RF16 | PSUN203 Deep Characterization of Pancreas Volume of New-Onset Type 1 Diabetes Patients Reveals Puberty-Specific Patterns and New Topographic Correlations with Pancreatic Functions.
  6. 173646
    “…Post-hoc lipid analysis demonstrated a reversible increase in mean serum LDL during treatment (680-mg: 58.7%; 340-mg: 30.8%; 255-mg: 19.0%) vs placebo (-3.9%),.In conclusion, batoclimab reduced circulating IgG and especially the pathogenic anti-TSHR-Ab. …”
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    RF35 | PSAT269 Double-Blind, Randomized, Placebo-controlled, Multicenter, Phase 2b Study of Batoclimab in Active and Moderate-to-Severe Thyroid Eye Disease
  7. 173647
    “…Associations even 5 to 10 years before diagnosis included tremor (odds ratio [OR], 4.49; 95% CI, 3.98-5.06), restless legs syndrome (OR, 3.73; 95% CI, 3.39-4.09), bipolar disorder (OR, 3.80; 95% CI, 2.82-5.14), and schizophrenia (OR, 4.00; 95% CI, 3.31-4.85). …”
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    Widening the Spectrum of Risk Factors, Comorbidities, and Prodromal Features of Parkinson Disease
  8. 173648
    “…RESULTS: From the COALA study, interview and reported symptom data were available for 289 children from the participating day care centers. Of 39 children with a SARS-CoV‑2 infection (wild-type, α‑variant), 64% had at least 1 symptom; of the children who tested negative for SARS-CoV‑2, 40% had at least 1 symptom. …”
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    Symptomatik einer akuten SARS-CoV-2-Infektion bei Kindern im Kita-Alter
  9. 173649
    “…RESULTS: By 1 month post-birth, MomsTalkShots increased perceived risk of maternal influenza disease (61% among MomsTalkShots recipients vs 55% among controls; Odds Ratio: 1.61, 95% Confidence Interval: 1.23–2.09), confidence in influenza vaccine efficacy (73% vs 63%; OR: 1.97, 95%CI: 1.47–2.65), and perceived vaccine knowledge (55% vs 48%; OR: 1.39, 95%CI: 1.13–1.72). Among those intending not to vaccinate at baseline, MomsTalkShots increased perceived risk of maternal influenza disease (38% vs 32%; OR: 2.07, 95%CI: 1.15–3.71) and confidence in influenza vaccine efficacy (44% vs 28%; OR: 2.62, 95%CI: 1.46–4.69). …”
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    MomsTalkShots, tailored educational app, improves vaccine attitudes: a randomized controlled trial
  10. 173650
    “…The mean volume of the skin receiving a 200% dose in the group with post-radiation reactions was 28.05 ± 16.56 cm(3), the median was 24.86 (0.5–52.3) cm(3), and the mean volume in the group without post-radiation reaction was 17.98 ± 10.96 cm(3), median 14.95 (3.9–44.96) cm(3). The result was statistically significant (Z = 2.035, p = 0.041). …”
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    Brachytherapy in the Treatment of Non-Melanoma Skin Peri-Auricular Cancers—A Retrospective Analysis of a Single Institution Experience
  11. 173651
    “…Fibrinolysis was chosen in 10% of patients, mostly in “Castelo Branco” (53%), followed by “Guarda” (30%), with a median time delay of 39 and 48 minutes, respectively. Regarding mortality, PCI and fibrinolysis groups had similar death rates while those patients without reperfusion had higher mortality (5% vs. 3% vs. 13%, P=0.001). …”
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    The role of process mining tools in STEMI networks: where should we build a new primary PCI centre?
  12. 173652
    “…These phospho-epitopes also discriminated between Aβ-positive and Aβ-negative cognitively unimpaired individuals: pT217 (TRIAD: AUC = 83.26, fold change = 2.39; BioFINDER-2: AUC = 91.05%, fold change = 3.29), pT231 (TRIAD: AUC = 86.25, fold change = 3.80; BioFINDER-2: AUC = 78.69%, fold change = 3.65) and pT205 (TRIAD: AUC = 71.58, fold change = 1.51; BioFINDER-2: AUC = 71.11%, fold change = 1.70). …”
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    Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer’s disease continuum
  13. 173653
    “…La consommation d’immunoglobulines sur la période pour l’indication de PIMS était de 3,9 kg ce qui représente 3,8 % des consommations totales d’immunoglobulines de notre hôpital sur la période étudiée. …”
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    Peut-on encore utiliser les immunoglobulines IV dans une indication émergente ? Le cas des PIMS
  14. 173654
    “…Overall, in our study population, median hospital LOS and ICU LOS were 42.0 (IQR=39.0) and 15.5 (IQR=37.0) days, respectively. There was a statistically significant longer median hospital LOS for patients with MDR/XDR infections compared to non MDR/XDR PA infections (53.0 vs. 36.5 days, p=0.04). …”
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    415. Epidemiological Evaluation of Antibiotic Resistance and Subsequent Effect on Healthcare Resource Utilization among Subjects with Pseudomonas aeruginosa Infections in Italy
  15. 173655
    por Meagher, Nicola S., Gorringe, Kylie L., Wakefield, Matthew, Bolithon, Adelyn, Pang, Chi Nam Ignatius, Chiu, Derek S., Anglesio, Michael S., Mallitt, Kylie-Ann, Doherty, Jennifer A., Harris, Holly R., Schildkraut, Joellen M., Berchuck, Andrew, Cushing-Haugen, Kara L., Chezar, Ksenia, Chou, Angela, Tan, Adeline, Alsop, Jennifer, Barlow, Ellen, Beckmann, Matthias W., Boros, Jessica, Bowtell, David D.L., Brand, Alison H., Brenton, James D., Campbell, Ian, Cheasley, Dane, Cohen, Joshua, Cybulski, Cezary, Elishaev, Esther, Erber, Ramona, Farrell, Rhonda, Fischer, Anna, Fu, Zhuxuan, Gilks, Blake, Gill, Anthony J., Gourley, Charlie, Grube, Marcel, Harnett, Paul R., Hartmann, Arndt, Hettiaratchi, Anusha, Høgdall, Claus K., Huzarski, Tomasz, Jakubowska, Anna, Jimenez-Linan, Mercedes, Kennedy, Catherine J., Kim, Byoung-Gie, Kim, Jae-Weon, Kim, Jae-Hoon, Klett, Kayla, Koziak, Jennifer M., Lai, Tiffany, Laslavic, Angela, Lester, Jenny, Leung, Yee, Li, Na, Liauw, Winston, Lim, Belle W.X., Linder, Anna, Lubiński, Jan, Mahale, Sakshi, Mateoiu, Constantina, McInerny, Simone, Menkiszak, Janusz, Minoo, Parham, Mittelstadt, Suzana, Morris, David, Orsulic, Sandra, Park, Sang-Yoon, Pearce, Celeste Leigh, Pearson, John V., Pike, Malcolm C., Quinn, Carmel M., Mohan, Ganendra Raj, Rao, Jianyu, Riggan, Marjorie J., Ruebner, Matthias, Salfinger, Stuart, Scott, Clare L., Shah, Mitul, Steed, Helen, Stewart, Colin J.R., Subramanian, Deepak, Sung, Soseul, Tang, Katrina, Timpson, Paul, Ward, Robyn L., Wiedenhoefer, Rebekka, Thorne, Heather, Cohen, Paul A., Crowe, Philip, Fasching, Peter A., Gronwald, Jacek, Hawkins, Nicholas J., Høgdall, Estrid, Huntsman, David G., James, Paul A., Karlan, Beth Y., Kelemen, Linda E., Kommoss, Stefan, Konecny, Gottfried E., Modugno, Francesmary, Park, Sue K., Staebler, Annette, Sundfeldt, Karin, Wu, Anna H., Talhouk, Aline, Pharoah, Paul D.P., Anderson, Lyndal, DeFazio, Anna, Köbel, Martin, Friedlander, Michael L., Ramus, Susan J.
    Publicado 2022
    “…ERBB2 (HER2) amplification or high mRNA expression was evident in 64 of 243 (26%) of MOCs, but only 8 of 243 (3%) were also infiltrative (4/39, 10%) or stage III/IV (4/31, 13%). CONCLUSIONS: An infiltrative growth pattern infers poor prognosis within 2 years from diagnosis and may help select stage I patients for adjuvant therapy. …”
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    Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes
  16. 173656
    “…Transplacental transfer ratios (all groups) were 1.39 to 1.83. Infant GMTs were higher in infants whose mothers had received RSVpreF versus placebo through 6 months of life; the estimated half-life of infant combined 50% RSV-A/B neutralizing titers was 41 days. …”
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    91. Establishing Proof of Concept for a Bivalent RSVpreF Subunit Vaccine for Maternal Immunization
  17. 173657
    “…Micro-NT was found to be highly reproducible (inter-assay CV of 11.39%). Screening 190 convalescent samples and 11 COVID-19 naive controls (AIID cohort) we achieved an assay sensitivity of 90% and specificity of 81%. …”
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    1057. Development of a Flow Cytometry-Based Micro-Neutralisation Assay to Evaluate Humoral Immunity Against SARS-CoV-2 Variants of Concern in Vaccine Trials
  18. 173658
    “…RESULTS: A total of 1861 ARI events were reported among 992 adults and 869 children in 470 households; 75 influenza cases were detected (36 influenza A and 39 influenza B). The study participant median age was 32 years (0-84), 10 years (1-49) for influenza A, and 11 years (3-49) for influenza B cases. …”
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    2202. Influenza Surveillance of Families in an Observational Household Study 2019-2021
  19. 173659
    “…Median time to antivirals was 1·0 h (IQR 0·0 to 2·0) in the mPOCT group versus 6·0 h (0·0 to 12·0) in the control group (difference of 5·0 h [95% CI 0·0–6·0; p=0·0039]). 70 (70%) of 100 patients with influenza in the mPOCT group were isolated to single-room accommodation versus 39 (38%) of 102 in the control group (relative risk 1·8 [95% CI 1·4–2·4; p<0·0001]). 19 adverse events occurred among patients with influenza in the mPOCT group compared with 34 events in the control group. …”
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    Clinical impact of a routine, molecular, point-of-care, test-and-treat strategy for influenza in adults admitted to hospital (FluPOC): a multicentre, open-label, randomised controlled trial
  20. 173660
    “…The relative average annual increase in psychotropic medicine sales from 2008 to 2019 was greater in upper-middle-income countries (7·88%, 95% CI 6·99–8·77) than in lower-middle-income countries (2·90%, 2·40–3·39) and high-income countries (1·02%, 0·80–1·24). …”
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    Psychotropic medicine consumption in 65 countries and regions, 2008–19: a longitudinal study
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