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  1. 173761
    por Pagnamenta, Alistair T., Camps, Carme, Giacopuzzi, Edoardo, Taylor, John M., Hashim, Mona, Calpena, Eduardo, Kaisaki, Pamela J., Hashimoto, Akiko, Yu, Jing, Sanders, Edward, Schwessinger, Ron, Hughes, Jim R., Lunter, Gerton, Dreau, Helene, Ferla, Matteo, Lange, Lukas, Kesim, Yesim, Ragoussis, Vassilis, Vavoulis, Dimitrios V., Allroggen, Holger, Ansorge, Olaf, Babbs, Christian, Banka, Siddharth, Baños-Piñero, Benito, Beeson, David, Ben-Ami, Tal, Bennett, David L., Bento, Celeste, Blair, Edward, Brasch-Andersen, Charlotte, Bull, Katherine R., Cario, Holger, Cilliers, Deirdre, Conti, Valerio, Davies, E. Graham, Dhalla, Fatima, Dacal, Beatriz Diez, Dong, Yin, Dunford, James E., Guerrini, Renzo, Harris, Adrian L., Hartley, Jane, Hollander, Georg, Javaid, Kassim, Kane, Maureen, Kelly, Deirdre, Kelly, Dominic, Knight, Samantha J. L., Kreins, Alexandra Y., Kvikstad, Erika M., Langman, Craig B., Lester, Tracy, Lines, Kate E., Lord, Simon R., Lu, Xin, Mansour, Sahar, Manzur, Adnan, Maroofian, Reza, Marsden, Brian, Mason, Joanne, McGowan, Simon J., Mei, Davide, Mlcochova, Hana, Murakami, Yoshiko, Németh, Andrea H., Okoli, Steven, Ormondroyd, Elizabeth, Ousager, Lilian Bomme, Palace, Jacqueline, Patel, Smita Y., Pentony, Melissa M., Pugh, Chris, Rad, Aboulfazl, Ramesh, Archana, Riva, Simone G., Roberts, Irene, Roy, Noémi, Salminen, Outi, Schilling, Kyleen D., Scott, Caroline, Sen, Arjune, Smith, Conrad, Stevenson, Mark, Thakker, Rajesh V., Twigg, Stephen R. F., Uhlig, Holm H., van Wijk, Richard, Vona, Barbara, Wall, Steven, Wang, Jing, Watkins, Hugh, Zak, Jaroslav, Schuh, Anna H., Kini, Usha, Wilkie, Andrew O. M., Popitsch, Niko, Taylor, Jenny C.
    Publicado 2023
    “…RESULTS: Our diagnostic yield was 43/122 cases (35%), although 47/122 cases (39%) were considered solved when considering novel candidate genes with supporting functional data into account. …”
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    Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases
  2. 173762
    “…METHODS: 40 patients (44 hips) with early osteonecrosis of the femoral head treated by drilling decompression autologous bone marrow and allogeneic bone grafting since October 2015 were retrospectively analyzed, among which 20 patients (24 hips) were HIV-positive patients with early osteonecrosis of the femoral head, 16 males and 4 females, age 22–43 years, average 39.6 ± 10.18 years, and 20 patients (20 hips) in the same period HIV-negative early osteonecrosis of the femoral head patients, 13 males and 7 females, aged 48–78 years, mean 63.50 ± 7.94 years were negative controls. …”
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    Analysis of the efficacy of drilling decompression autologous bone marrow and allogeneic bone grafting in the treatment of HIV-positive patients with early osteonecrosis of the femoral head
  3. 173763
    “…Among a total 562 reads by experienced radiologists over 2 reading rounds, per-patient specificity was 86.2% (ML) and 87.7% (non-ML) (−1.5% difference; 95% confidence interval [CI], −6.4%, 3.5%; P = 0.39). Sensitivity was 66.0% (ML) and 70.0% (non-ML) (−4.0% difference; 95% CI, −13.5%, 5.5%; P = 0.344). …”
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    Development and Evaluation of Machine Learning in Whole-Body Magnetic Resonance Imaging for Detecting Metastases in Patients With Lung or Colon Cancer: A Diagnostic Test Accuracy Study
  4. 173764
    “…RESULTS: A total of 129 samples from 39 patients were analyzed; 24 with URTI only, 8 progressors, and 7 with LRTI only. …”
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    2712. Respiratory syncytial virus (RSV) pre-fusion F antibody titers in hematopoietic cell transplant recipients with upper versus lower respiratory tract infections
  5. 173765
    “…BACKGROUND: The RAPIDS GN trial, a prospective randomized controlled trial, showed that rapid blood culture antibiotic susceptibility testing (AST) led to faster antibiotic therapy changes compared to standard of care (SOC) testing for Gram negative bacteremia (Banerjee et al, Clin Infect Dis (2021) 73:e39-e46). A secondary analysis of the data was conducted to assess impact of rapid testing on appropriateness of antibiotic spectrum by pathogen and resistance profile. …”
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    857. Impact of Rapid Antibiotic Susceptibility Testing for Gram Negative Bacteremia Varies by Pathogen Type and Resistance: A Secondary Analysis of the RAPIDS GN Trial
  6. 173766
    “…Other factors associated with any O2 were BMI > 35 kg/m2 {35.0-39.9 (2.4 [1.09-5.26]), > 40.0 (3.29 [1.34-8.1]) compared to < 24.9} and age 65-74 (2.13 [1.03-4.38]) compared to 50- 64 years; with high level O2 were cardiomyopathy (2.11 [1.04-4.32) and male gender (1.93 [1.01-3.7]); with MV or death were cardiomyopathy (2.67 [1.11-6.42]) and CKD (3.17 [1.27-7.96]). …”
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    432. Predictors for oxygen requirements in patients hospitalized with COVID-19 during the Omicron surge, January 2022
  7. 173767
    “…When controlling for race, age, and employment, the odds of PNA (OR 0.5 (0.34, 0.74)) and ICU admission (0.61 (0.39, 0.97)) were less for those with two doses than those with none; whereas those with three mRNA doses had less odds of having PNA (OR 0.26 (0.15, 0.46) and LOS ≥ 4 days (OR 0.44 (0.25, 0.76)). …”
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    2364. Predictive Ability of mRNA COVID-19 Vaccines Against COVID-19 Disease Severity
  8. 173768
    por Noguchi, Hideyo
    Publicado 1921
    “…A fragment of two or three waves may be encountered in a preparation containing many degenerated organisms (Fig. 39). The composition of the crista can best be studied in degenerated remains of the organism. …”
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    CRISTISPIRA IN NORTH AMERICAN SHELLFISH. A NOTE ON A SPIRILLUM FOUND IN OYSTERS
  9. 173769
    por White, A. C.
    Publicado 1925
    “…Koehler (22) gives a series of blood pH determinations in acute fevers in which ten out of twelve cases showed an uncompensated alkalosis when the temperature was 103°F. (39.4°C.) or over. Pemberton and Crouter (23) in a study on the response to the therapeutic application of external heat also observed a tendency for the reaction to shift to the alkaline side as shown by the alteration in the pH of the sweat. …”
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    THE BICARBONATE RESERVE AND THE DISSOCIATION CURVE OF OXYHEMOGLOBIN IN FEBRILE CONDITIONS
  10. 173770
    por Gaudet, Mia M., Kuchenbaecker, Karoline B., Vijai, Joseph, Klein, Robert J., Kirchhoff, Tomas, McGuffog, Lesley, Barrowdale, Daniel, Dunning, Alison M., Lee, Andrew, Dennis, Joe, Healey, Sue, Dicks, Ed, Soucy, Penny, Sinilnikova, Olga M., Pankratz, Vernon S., Wang, Xianshu, Eldridge, Ronald C., Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Hogervorst, Frans B. L., Peock, Susan, Stoppa-Lyonnet, Dominique, Peterlongo, Paolo, Schmutzler, Rita K., Nathanson, Katherine L., Piedmonte, Marion, Singer, Christian F., Thomassen, Mads, Hansen, Thomas v. O., Neuhausen, Susan L., Blanco, Ignacio, Greene, Mark H., Garber, Judith, Weitzel, Jeffrey N., Andrulis, Irene L., Goldgar, David E., D'Andrea, Emma, Caldes, Trinidad, Nevanlinna, Heli, Osorio, Ana, van Rensburg, Elizabeth J., Arason, Adalgeir, Rennert, Gad, van den Ouweland, Ans M. W., van der Hout, Annemarie H., Kets, Carolien M., Aalfs, Cora M., Wijnen, Juul T., Ausems, Margreet G. E. M., Frost, Debra, Ellis, Steve, Fineberg, Elena, Platte, Radka, Evans, D. Gareth, Jacobs, Chris, Adlard, Julian, Tischkowitz, Marc, Porteous, Mary E., Damiola, Francesca, Golmard, Lisa, Barjhoux, Laure, Longy, Michel, Belotti, Muriel, Ferrer, Sandra Fert, Mazoyer, Sylvie, Spurdle, Amanda B., Manoukian, Siranoush, Barile, Monica, Genuardi, Maurizio, Arnold, Norbert, Meindl, Alfons, Sutter, Christian, Wappenschmidt, Barbara, Domchek, Susan M., Pfeiler, Georg, Friedman, Eitan, Jensen, Uffe Birk, Robson, Mark, Shah, Sohela, Lazaro, Conxi, Mai, Phuong L., Benitez, Javier, Southey, Melissa C., Schmidt, Marjanka K., Fasching, Peter A., Peto, Julian, Humphreys, Manjeet K., Wang, Qin, Michailidou, Kyriaki, Sawyer, Elinor J., Burwinkel, Barbara, Guénel, Pascal, Bojesen, Stig E., Milne, Roger L., Brenner, Hermann, Lochmann, Magdalena, Aittomäki, Kristiina, Dörk, Thilo, Margolin, Sara, Mannermaa, Arto, Lambrechts, Diether, Chang-Claude, Jenny, Radice, Paolo, Giles, Graham G., Haiman, Christopher A., Winqvist, Robert, Devillee, Peter, García-Closas, Montserrat, Schoof, Nils, Hooning, Maartje J., Cox, Angela, Pharoah, Paul D. P., Jakubowska, Anna, Orr, Nick, González-Neira, Anna, Pita, Guillermo, Alonso, M. Rosario, Hall, Per, Couch, Fergus J., Simard, Jacques, Altshuler, David, Easton, Douglas F., Chenevix-Trench, Georgia, Antoniou, Antonis C., Offit, Kenneth
    Publicado 2013
    “…We also identified a novel susceptibility allele at 6p24 that was inversely associated with risk in BRCA2 mutation carriers (rs9348512; per allele HR = 0.85, 95% CI 0.80–0.90, P = 3.9×10(−8)). This SNP was not associated with breast cancer risk either in the general population or in BRCA1 mutation carriers. …”
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    Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk
  11. 173771
    “…Patients were excluded if they received more than 1 L of 6% HES within 24 hours of screening or had one of the following: dialysis-dependent or impending dialysis renal failure, computed tomography evidence of non-traumatic intracranial hemorrhage (ICH) or severe traumatic ICH, creatinine of more than 3.9 mg/dL or urine output of less than 10 mL/hour for 12 hours, sodium of more than 160 meq/L, or chloride of more than 130 meq/L. …”
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    Crystalloids vs. colloids: KO at the twelfth round?
  12. 173772
    por Medici, Marco, Porcu, Eleonora, Pistis, Giorgio, Teumer, Alexander, Brown, Suzanne J., Jensen, Richard A., Rawal, Rajesh, Roef, Greet L., Plantinga, Theo S., Vermeulen, Sita H., Lahti, Jari, Simmonds, Matthew J., Husemoen, Lise Lotte N., Freathy, Rachel M., Shields, Beverley M., Pietzner, Diana, Nagy, Rebecca, Broer, Linda, Chaker, Layal, Korevaar, Tim I. M., Plia, Maria Grazia, Sala, Cinzia, Völker, Uwe, Richards, J. Brent, Sweep, Fred C., Gieger, Christian, Corre, Tanguy, Kajantie, Eero, Thuesen, Betina, Taes, Youri E., Visser, W. Edward, Hattersley, Andrew T., Kratzsch, Jürgen, Hamilton, Alexander, Li, Wei, Homuth, Georg, Lobina, Monia, Mariotti, Stefano, Soranzo, Nicole, Cocca, Massimiliano, Nauck, Matthias, Spielhagen, Christin, Ross, Alec, Arnold, Alice, van de Bunt, Martijn, Liyanarachchi, Sandya, Heier, Margit, Grabe, Hans Jörgen, Masciullo, Corrado, Galesloot, Tessel E., Lim, Ee M., Reischl, Eva, Leedman, Peter J., Lai, Sandra, Delitala, Alessandro, Bremner, Alexandra P., Philips, David I. W., Beilby, John P., Mulas, Antonella, Vocale, Matteo, Abecasis, Goncalo, Forsen, Tom, James, Alan, Widen, Elisabeth, Hui, Jennie, Prokisch, Holger, Rietzschel, Ernst E., Palotie, Aarno, Feddema, Peter, Fletcher, Stephen J., Schramm, Katharina, Rotter, Jerome I., Kluttig, Alexander, Radke, Dörte, Traglia, Michela, Surdulescu, Gabriela L., He, Huiling, Franklyn, Jayne A., Tiller, Daniel, Vaidya, Bijay, de Meyer, Tim, Jørgensen, Torben, Eriksson, Johan G., O'Leary, Peter C., Wichmann, Eric, Hermus, Ad R., Psaty, Bruce M., Ittermann, Till, Hofman, Albert, Bosi, Emanuele, Schlessinger, David, Wallaschofski, Henri, Pirastu, Nicola, Aulchenko, Yurii S., de la Chapelle, Albert, Netea-Maier, Romana T., Gough, Stephen C. L., Meyer zu Schwabedissen, Henriette, Frayling, Timothy M., Kaufman, Jean-Marc, Linneberg, Allan, Räikkönen, Katri, Smit, Johannes W. A., Kiemeney, Lambertus A., Rivadeneira, Fernando, Uitterlinden, André G., Walsh, John P., Meisinger, Christa, den Heijer, Martin, Visser, Theo J., Spector, Timothy D., Wilson, Scott G., Völzke, Henry, Cappola, Anne, Toniolo, Daniela, Sanna, Serena, Naitza, Silvia, Peeters, Robin P.
    Publicado 2014
    “…The MAGI3 and BACH2 variants were associated with an increased risk of hyperthyroidism, which was replicated in an independent cohort of patients with Graves' disease (OR: 1.37, 95% CI 1.22–1.54, P = 1.2×10(−7) and OR: 1.25, 95% CI 1.12–1.39, P = 6.2×10(−5)). The MAGI3 variant was also associated with an increased risk of hypothyroidism (OR: 1.57, 95% CI 1.18–2.10, P = 1.9×10(−3)). …”
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    Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease
  13. 173773
    “…Additionally, leadership-teamwork index also correlated with patient rating of surgeon respect (0.46, p = 0.019) and patient impression of clarity of the surgeon’s explanation (0.39, p = 0.05). Multivariate analyses supported retention of insight impact as a predictor of patient overall satisfaction, patient recommendation of the surgeon, and patient rating of surgeon respect. …”
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    Do 360-degree Feedback Survey Results Relate to Patient Satisfaction Measures?
  14. 173774
    “…Splitting praziquantel 40 mg/kg into two doses over 12 hours probably has no benefits over a single dose, and in a single trial of 220 participants the split dose caused more vomiting (RR 0.5, 95% CI 0.29 to 0.86) and dizziness (RR 0.39, 95% CI 0.16 to 0.94). Metrifonate A single dose of metrifonate 10 mg/kg reduced egg excretion (210 participants, one trial, at eight months), but was only marginally better than placebo at achieving cure at one month (RR 0.83, 95% CI 0.74 to 0.94, 142 participants, one trial). …”
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    Drugs for treating urinary schistosomiasis
  15. 173775
    “…Compared to the intraosseous group, patients in the intravenous group were more likely to experience an insertion failure (risk ratio (RR) 3.89, 95% confidence interval (CI) 2.39 to 6.33; n = 242; GRADE rating: low). We did not pool data for time to insertion but estimates from the trials suggest that inserting intravenous access takes longer (GRADE rating: moderate). …”
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    Comparison of routes for achieving parenteral access with a focus on the management of patients with Ebola virus disease
  16. 173776
    “…DHA‐P versus artemether‐lumefantrine In Africa, over 28 days follow‐up, DHA‐P is superior to artemether‐lumefantrine at preventing further parasitaemia (PCR‐unadjusted treatment failure: RR 0.34, 95% CI 0.30 to 0.39, nine trials, 6200 participants, high quality evidence), and although PCR‐adjusted treatment failure was below 5% for both ACTs, it was consistently lower with DHA‐P (PCR‐adjusted treatment failure: RR 0.42, 95% CI 0.29 to 0.62, nine trials, 5417 participants, high quality evidence). …”
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    Dihydroartemisinin‐piperaquine for treating uncomplicated Plasmodium falciparum malaria
  17. 173777
    “…Respondent attitudes were categorized as positive (score >26), neutral (score 13–26), or negative (score <13), based on a maximum total score of 39. Mixed-gender FGDs in each sub-village (banjar) were conducted, each involving 7–15 participants to complement the questionnaire results. …”
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    On dogs, people, and a rabies epidemic: results from a sociocultural study in Bali, Indonesia
  18. 173778
    “…The change in the mean number of cannabis use days per week at 3 months differed between self-help without chat (mean change 0.7, SD -0.2) and self-help with chat (mean change 1.4, SD -0.5; beta=-0.75, SE=0.32, t=-2.39, P=.02, d=0.34, 95% CI 0.07-0.61), as well as between self-help with chat and waiting list (mean change 1.0, SD -0.8; beta=0.70, SE=0.32, t=2.16, P=.03, d=0.20, 95% CI -0.07 to 0.47). …”
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    A Web-Based Self-Help Intervention With and Without Chat Counseling to Reduce Cannabis Use in Problematic Cannabis Users: Three-Arm Randomized Controlled Trial
  19. 173779
    “…Our analyses regarding dose–response relationships in BT revealed that a training period of 11–12 weeks (mean SMD(bs)= 1.26), a frequency of three training sessions per week (mean SMD(bs)= 1.20), a total number of 36–40 training sessions (mean SMD(bs) = 1.39), a duration of a single training session of 31–45 min (mean SMD(bs) = 1.19), and a total duration of 91–120 min of BT per week (mean SMD(bs) = 1.93) of the applied training modalities is most effective in improving overall balance performance. …”
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    Effects of Balance Training on Balance Performance in Healthy Older Adults: A Systematic Review and Meta-analysis
  20. 173780
    “…However, the total adverse event rate was not decreased in the adult group (RR = 0.80, 95% CI: 0.61–1.04, P = 0.1) or the Asian group (RR = 0.68, 95% CI: 0.39–1.18, P = 0.17). Subgroup analyses examining therapy regimens and treatment durations showed that probiotic supplementation increased eradication rates in the triple-therapy (RR = 1.18, 95% CI: 1.12–1.25, P<0.00001), seven-day treatment (RR = 1.21, 95% CI: 1.12–1.31, P<0.00001) and fourteen-day treatment (RR = 1.13, 95% CI: 1.06–1.20, P = 0.0002) groups. …”
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    Efficacy of Probiotic Supplementation Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials
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