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  1. 174161
    “…Similarly, clinical improvement at d14, measured as ≥2-point increase in the ordinal scale, was lower in Italian patients (39%) compared to all other countries combined (64%). …”
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    73. Geographical Disparities in Clinical Outcomes of Severe COVID-19 Patients Treated with Remdesivir
  2. 174162
    “…Working 49–54 h/week did not increase the risk of developing risky drinking (relative risk 1.12; 95% CI 0.90–1.39; 12 studies; 3832 participants; I(2) 24%, moderate certainty evidence), nor working ≥55 h/week (relative risk 1.11; 95% CI 0.95–1.30; 12 studies; 4525 participants; I(2) 0%, moderate certainty evidence). …”
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    The effect of exposure to long working hours on alcohol consumption, risky drinking and alcohol use disorder: A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related burden of disease and injury
  3. 174163
    “…Among participants aged 50 years or older, neutralising antibody titres after two vaccine doses were 8·62 (1·90–39·0) in the low-dose plus AF03 group, 12·9 (7·09–23·4) in the low-dose plus AS03 group, 12·3 (4·35–35·0) in the high-dose plus AF03 group, 52·3 (25·3–108·0) in the high-dose plus AS03 group, and 5·00 (not calculated) in the placebo group. …”
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    Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1–2, dose-ranging study
  4. 174164
    por van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Pyae Phyo, Aung, Lek, Dysoley, ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen Thanh, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valecha, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas P J, White, Nicholas J, Dondorp, Arjen M
    Publicado 2020
    “…In Cambodia, Thailand, and Vietnam the 42-day PCR-corrected efficacy after dihydroartemisinin–piperaquine plus mefloquine was 98% (149 of 152; 95% CI 94 to 100) and after dihydroartemisinin–piperaquine was 48% (67 of 141; 95% CI 39 to 56; risk difference 51%, 95% CI 42 to 59; p<0·0001). …”
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    Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial
  5. 174165
    “…RESULTS: There were 88 patients (89.8% male) with a mean age of 39.6 years (range 18-65) and minimum 2-year follow-up (mean 6.1 years, range 2.1-10.3). …”
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    Arthroscopic-Assisted Coracoclavicular Ligament Reconstruction: Clinical Outcomes and Return to Activity at Mean Six-Year Follow-up
  6. 174166
    “…The type of TKI currently assumed was imatinib (n=134, 39.5%), nilotinib (n=63, 18.6%), dasatinib (n=52, 15.4%), bosutinib (n= 24, 7.1%), ponatinib (n=14, 4.1%) or experimental (n=2, 0.6%). …”
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    Serological Prevalence of Sars-Cov-2 Infection Among Chronic Myeloid Leukemia Patients Undergoing Tyrosine Kinase Inhibitor Treatment in Italy (COVID-19-HEM Study)
  7. 174167
    “…On a 0-10 scale, 21/61 patients endorsed “0” for worry that they would be COVID-infected by going for medical care (weighted mean 3.9), but 18/59 endorsed “10” for worry they were more at risk of COVID because of SCD (weighted mean 6.31), and 22/60 endorsed “10” for worry they would fare worse than others if COVID infected (weighted mean 6.97). …”
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    COVID Symptoms and COVID Anxiety in Sickle Cell Disease
  8. 174168
    “…Comorbidities, assessed by Charlson score, was also not statistically different between both groups (median score 0 (IQR, 0-1) in both groups, P=0.39). Majority of our patients had relatively mild infection as reflected by the low proportions of them requiring oxygen supplementation (11.0% in COVID-19 vs 4.8% in non-SARS-COV-2, P=0.035). …”
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    Thrombotic Events in COVID-19 Patients and Its Comparison with Other Non-Sars-Cov-2 Respiratory Viruses
  9. 174169
    “…Among women with AMH ≥15 pmol/l, excessive response occurred less frequently with individualised follitropin delta than with follitropin alfa (≥15 oocytes: 20.2% versus 39.1%; ≥20 oocytes: 6.7% versus 18.5%; both P < 0.001). …”
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    A randomised controlled trial to clinically validate follitropin delta in its individualised dosing regimen for ovarian stimulation in Asian IVF/ICSI patients
  10. 174170
    “…Secondary outcomes Moderate‐certainty evidence suggests that people using compression bandages or stockings probably have a lower mean pain score than those not using compression (four studies with 859 participants and another study with 69 ulcers): pooled mean difference −1.39, 95% CI −1.79 to −0.98; I(2) = 65% (two studies with 426 participants and another study with 69 ulcers having analysable data); synthesis without meta‐analysis suggests a reduction in leg ulcer pain in compression bandages or stockings, compared with no compression (two studies without analysable data, 433 participants). …”
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    Compression bandages or stockings versus no compression for treating venous leg ulcers
  11. 174171
    “…RÉSULTATS: Les analyses toxicologiques (CL-SM/SM et CL-SMHR) mettent en évidence, à l’exclusion de tout autre toxique, du TR [sang cardiaque (SC) 6240 μg/L (toxicité adulte > 800 μg/L) ; urine (UR) 291 mg/L], de l’O-desméthyl-TR (O-DMT) [SC 902 μg/L ; UR 127 mg/L] et du N-desméthyl-TR (N-DMT) [SC 993 μg/L ; UR 39,8 mg/L]. Au-delà de questions d’ontogénie et du génotype CYP2D6 de l’enfant [CYP2D6*1/*17 cohérent avec les ratios métaboliques (RM) SG et UR], ces résultats sont compatibles avec une administration de TR ayant entraîné des effets toxiques majeurs potentiellement létaux (dépression respiratoire sévère, coma, convulsions, troubles cardiaques) chez cet enfant. …”
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    Mort inattendue du nourrisson en lien avec une addiction maternelle au tramadol
  12. 174172
    “…A mediana de idade, em anos, foi 55.77 (IQR 42.31 a 66.68) no grupo COVID-19 e 59.04 (IQR 45.13 a 69.73, P = 0.39) no grupo não-COVID-19. Ambos os grupos apresentaram um escore de Pádua (COVID-19: 3 IQR 2 a 4; não-COVID-19: 3 IQR 2 a 5, P = 0.47) e uma saturação de oxigênio (COVID-19: 92% IQR 90% a 96%; não-COVID-19: 94% IQR 91% a 97%, P = 0.44) semelhantes à admissão. …”
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    DIAGNÓSTICO DA COVID-19 E SEU IMPACTO SOBRE O RISCO TROMBÓTICO EM UMA COORTE DE PACIENTES SIMULTANEAMENTE HOSPITALIZADOS POR SÍNDROME RESPIRATÓRIA AGUDA GRAVE
  13. 174173
    “…À l’examen clinique on retrouve une fièvre à 39 °C, une raideur de nuque, GSC 12 sans signe de localisation ni convulsion, sans purpura ni défaillance hémodynamique. …”
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    PCR Covid19: votre vaccination antipneumococcique est-elle à jour?
  14. 174174
    “…In NHs participating in either initiative, staff COVID cases were reduced by 31% (OR=0.69 (0.52, 0.92), P=0.01), resident COVID cases were reduced by 43% (OR=0.57 (0.39, 0.82), P=0.003), and resident deaths were reduced (non-significantly) by 26% (OR=0.74 (0.46, 1.21), P=0.23). …”
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    44. Impact of Nursing Home (NH) Universal Decolonization and COVID Prevention Training on COVID-19 Burden During the 2020-2021 Winter Surge in Orange County (OC), California (CA)
  15. 174175
    “…SpFi group 1 >452, SpFi2 2: 315-452; SpFi 3 236-315, SpFi 4: <236 (respiratory distress) Results 53 patients were included: epidemiological and clinical data available on table 1. 23 patients (43.39%) arrived to SpFi4 status. WHOs >6 (WHO 6:oxygen by non invasive ventilation or high flow) was achieved by 20 patients (37.7%) Good prognosis (meaning SpFi1 as the worse respiratory status in the follow -up) was associated to cytometric profiles: there was a significant increase in CD3, p-DCs, m-DCs, basophils, monocytes, Tcm, % of lymphocytes and CD3/CD19 ratio whereas there was a significant reduction in CD19, % of neutrophils and % Neutrophils/% lymphocyte ratio. …”
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    Early Immune Profile Assessment By Flow Cytometry Predicts Severe COVID-19 Pneumonia
  16. 174176
    “…Of the 16 samples that were obtained post-vaccine dose 2, nine had IgG levels less than 2 µg/mL (manufacturer lower threshold of detection), whereas only 5 of 252 samples from the control cohort were less than this level (Chi-square P<0.001, RR =39.6 (95%CI 15.1-100)). Antibody responses were independent of type of therapy (Figure 2). …”
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    Antibody and T-Cell Responses to Covid-19 mRNA Vaccines in Patients with B-Cell Lymphomas and Chronic Lymphocytic Leukemia (CLL)
  17. 174177
    “…A weak reverse correlation of the antibody levels with the time after vaccination was noted ( r = - 0,39, p = 0,033). A very weak reverse correlation with age was observed ( r = - 0,28, p = 0,127) (Fig. 1, 2). …”
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    Humoral Immunity and Adverse Events after Vaccination Against COVID-19 By a Vector Based Vaccine Sputnik V in Patients with Chronic Myeloid Leukemia
  18. 174178
    “…Of the responders, the median time from HCT to 1st vacc was 45.5 months (range, 3-258, SD 39.78). Among the 23 pts between 3-9 months after HCT, 26% (n=6) had a positive antibody response, but all were receiving ongoing immunosuppression at time of vaccination. 29% (n=29) vacc responders were receiving prednisone (pred) in the management of cGvHD at the time of vaccination. 48 pts did not mount an antibody response (vacc non-responders). …”
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    Assessment of Serology after Sars-Cov-2 Vaccine in Allogeneic HCT Recipients
  19. 174179
    “…At the time of vaccine administration, 46 (75%) of pts were on active therapy and 39 (64%) of pts had active disease. Median time from the second vaccine dose to IgG spike antibody testing was 64 days (26-268 days). …”
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    COVID Vaccine Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Better Antibody Response in Patients with Myeloid Malignancies Than B-Cell Malignancies
  20. 174180
    “…Circulating levels of Ang1, Ang2, sTie2 and VEGF-A were all significantly increased in patients compared to healthy individuals (Ang1: 463.2 ± 194.6 vs 237.4 ± 104.9 pg/mL, p<0.0001; Ang2: 1,926 (1,275 - 3,134) vs 1,215 (9 - 1,440 pg/mL), p<0.0001; Tie2: 10,753 ± 2,377 vs 8,603 ± 1,851 pg/mL, p<0.0001 and VEGF-A: 94.7 (73.4 - 116.0) vs 45.9 (39.7 - 57.0 pg/mL), p<0.0001.). In contrast, soluble VE-cadherin levels were decreased in patients compared to healthy individuals (1,234 ± 318 vs 1,539 ± 363 ng/mL, P=0.001). …”
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    Circulating Levels of Ang/Tie2 and VEGF-a Pathway Mediators Are Associated with Clinical Severity, Endothelial Barrier Disruption and Coagulation Activation in COVID-19
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