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  1. 8841
  2. 8842
    “…Assessed efficacy endpoints included Assessments of SpondyloArthritis international Society (ASAS)20/40, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), BASDAI50, AS Disease Activity Score inactive disease and ASAS partial remission among patients grouped by baseline CRP based on central laboratory cut-off <5  mg/L (normal) or ≥5  mg/L (elevated) and a cut-off <10  mg/L or ≥10  mg/L. …”
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  3. 8843
  4. 8844
    “…The primary and key secondary endpoints were Assessment of SpondyloArthritis international Society ≥20% improvement (ASAS20) and ≥40% improvement (ASAS40) responses, respectively, at week 16. …”
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  5. 8845
    por Dou, Bin, Ma, Fuzhe, Jiang, Zhenyu, Zhao, Ling
    Publicado 2022
    “…Meanwhile, HDAC4 increased from W0 to W12 (P < 0.001); HDAC4 at W8 (P = 0.014) and W12 (P = 0.006) was raised in ASAS40-response patients than ASAS40-non-response patients; further subgroup analysis showed that HDAC4 at W12 was higher in ASAS40-response patients than ASAS40-non-response patients (P = 0.016) in the TNFi-treated group, but not in the NSAID-treated group. …”
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  6. 8846
  7. 8847
    “…RESULTS: In all, 2178 children were fathered by men exposed to 5‐ASAs, 843 to thiopurines, 417 to systemic corticosteroids and 436 to anti‐TNF‐α agents; 6799 children were unexposed. …”
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  8. 8848
    “…BACKGROUND: We assessed the external validity of composite indices Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and Assessment in SpondyloArthritis international Society (ASAS) 40 response (ASAS40) by evaluating the correlations between the changes in some patient reported outcomes (PROs) for patients with non-radiographic axial spondyloarthritis (nr-axSpA) and the changes in the scores of the composite indices. …”
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  9. 8849
    “…Number needed to treat (NNT) was calculated as the reciprocal of incremental response rate of each treatment versus placebo. Cost per ASAS40 responder (CPR) was calculated as the 16-week treatment costs divided by ASAS40 response rates. …”
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  10. 8850
    “…Of these, 93% completed week 24, 88% completed week 48, and 80% completed week 96. Improvements in ASAS responses were maintained to week 96 (for ASAS20, 67.4%, 72.0%, and 62.8% at weeks 24, 48, and 96, respectively), as well as improvements in ASDAS, BASDAI (mean score 3.3, 3.1, and 3.0 at weeks 24, 48, and 96, respectively), BASFI, and BASMI linear score. …”
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  11. 8851
    “…RESULTS: APOA5 rs662799 genotype distributions in both the KoGES-ASAS and KNHANES groups were 50.6% for TT, 41.3% for TC, and 8.1% for CC, which are similar to those in previous reports. …”
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  12. 8852
  13. 8853
    “…RESULTS: At week 104, 38.5%, 60.1% and 71.4% of patients in groups 1, 2 and 3, respectively, had at least 20% improvement in the Assessment in SpondyloArthritis international Society response criteria (ASAS20); 38.5%, 55.8% and 54.3% had an ASAS40 response and 21.8%, 31.9% and 30.7% were in ASAS partial remission. …”
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  14. 8854
  15. 8855
    “…The primary outcome was the ASAS20 response, and the secondary outcomes included the ASAS40 response, ASAS5/6 response, SF-36 PCS score, ASQoL score, and AEs. …”
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  16. 8856
    “…Evidence suggests that VC is associated with anti-sperm antibodies (ASAs), spermatogenesis and testosterone secretion abnormalities, and testicular cytokine production. …”
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  17. 8857
    “…Our review highlights the contemporary evaluation and management of ASAS and summarizes the current scientific evidence regarding optimal timing for intervention and indications for early AVR in such patients.…”
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  18. 8858
    por Aad, G, Bentvelsen, S, Bobbink, G J, Bos, K, Boterenbrood, H, Brouwer, G, Buis, E J, Buskop, J J F, Colijn, A P, Dankers, R, Daum, C, de Boer, R, de Jong, P, Ennes, P, Gosselink, M, Groenstege, H, Hart, R G G, Hartjes, F, Hendriks, P J, Hessey, N P, Jansweijer, P P M, Kieft, G, Klous, S, Kluit, P, Koffeman, E, Koutsman, A, Liebig, W, Limper, M, Linde, F, Luijckx, G, Massaro, G, Muijs, A, Peeters, S J M, Reichold, A, Rewiersma, P, Rijpstra, M, Scholte, R C, Schuijlenburg, H W, Snuverink, J, van der Graaf, H, van der Kraaij, E, Van Eijk, B, van Kesteren, Z, van Vulpen, I, Verkerke, W, Vermeulen, J C, Vreeswijk, M, Werneke, P, Cakir, O, Ciftci, A K, Duran Yildiz, H, Sultanov, S, Turk Cakir, I, Yilmaz, M, Aubert, B, Bazan, A, Beaugiraud, B, Bellachia, F, Berger, N, Blaising, J J, Colas, J, Consonni, M, Delebecque, P, Delsart, P A, Di Ciaccio, L, Dayot, N Dumont>, Elles, S, Ghez, Philippe>, Girard, C G, Gouanere, M, Goy, C, Guillemin, T, Ionescu, G, Jeremie, A, Jezequel, S, Lafaye, R, Laplace, S, Marchand, J F, Massol, N, Neukermans, L, Perrodo, P, Perrot, G, Prast, J, Przysiezniak, H, Sauvage, G, Thion, J, Wingerter-Seez, I, Zitoun, R, Zolnierowski, Y, Baranov, S, Blair, R E, Cranshaw, J, Dawson, J W, Drake, G, Fullana Torregrosa, E, Gieraltowski, G F, Grudzinski, J, Guarino, V J, Hill, D, Hill, N, Karr, K, LeCompte, T, Lim, H, Malon, D, May, E N, Nodulman, L J, Petereit, E, Price, L E, Proudfoot, J, Schlereth, J L, Stanek, R W, Underwood, D G, van Gemmeren, P, Vaniachine, A, Yoshida, R, Zhang, J, Cheu, E, Johns, K A, Lampl, W, Loch, P, Rutherfoord, J P, Savine, A Y, Shaver, L, Shupe, M A, Tompkins, D, Varnes, E W, Alexopoulos, T, Avramidou, R, Dris, M, Filippas, A, Fokitis, M, Gazis, E N, Katsoufis, E, Maltezos, S, Papadopoulou, T, Savva, P, Tsipolitis, G, Tzamariudaki, E, Vlachos, S, Antonaki, A, Arabidze, G, Fassouliotis, D, Giakoumopoulou, V, Giokaris, N, Ioannou, P, Kourkoumelis, C, Manousakis-Katsikakis, A, Nikolopoulos, K, Tzanakos, G, Vellidis, C, Abdinov, O, Aliyev, M, Huseynov, N, Khalilzade, F, Biscarat, C, Blanch, O, Blumenschein, U, Bosman, M, Bravo, S, Casado, M P, Cavalli-Sforza, M, Deluca Silberberg, C, Domingo, E, Dosil, M, Espinal Curull, X, Fiorini, L, Flix, J, Garitaonandia, H, Iglesias Escudero, M C, Korolkov, I, Mir, L M, Verge, L Miralles>, Norniella Francisco, O, Osuna, C, Pacheco Pages, A, Padilla Aranda, C, Park, I, Perez Codina, E, Puigdengoles, C, Dachs, I Riu>, Ruiz, H, Salto Bauza, O, Sanchez Sanchez, C A, Segura, E, Sushkov, S, Vives Vaques, F, Volpi, M, Chen, T, Cheng, S, Feng, C, Han, H, Han, L, He, M, Jiang, Y, Jin, G, Jin, S, Lu, F, Ouyang, Q, Pei, E, Ping, J, Qi, M, Shan, L, Tong, G, Xie, Y, Xu, G, Yang, Y, Yu, X, Zhang, H, Zhang, X, Zheng, S, Zhu, C G, Krstic, J, Milosavljevic, M, Popovic, D S, Reljic, D, Sijacki, D, Simic, L, Vranjes, N, Vudragovic, M, Buanes, T, Eigen, G, Johansen, L G, Kastanas, A, Lipniacka, A, Mohn, B, Sandaker, H, Stugu, B, Tonoyan, A, Kolanoski, H, Kwee, R, Lohse, T, zur Nedden, M, Ambrosini, G, Beck, H P, Borer, K, Ereditato, A, Gjelsten, B K, Haeberli, C, Haug, S, Hess, M, Kabana, S, Kordas, K, Pretzl, K, Thomas, E, Topfel, C, Booth, J R A, Bright-Thomas, P G, Charlton, D G, Curtis, C J, Dowell, J D, Garvey, J, Hillier, S J, Hollins, T I, Homer, R J, Jovanovic, P, Mahout, G, McMahon, T J, Moye, T H, O'Neale, S W, Staley, R J, Thomas, J P, Typaldos, D, Watkins, P M, Watson, A T, Wilson, J A, Woehrling, E, Antonelli, S, Bellagamba, L, Bertin, A, Boscherini, D, Bruni, A, Bruni, G, Bruschi, M, Caforio, D, Corradi, M, De Castro, S, Fabbri, L, Faccioli, P, Giacobbe, B, Giusti, P, Grimaldi, F, Iacobucci, G, Massa, I, Mazzanti, P, Piccinini, M, Polini, A, Sbarra, C, Sbrizzi, A, Semprini-Cesari, N, Spighi, R, Villa, M, Vitale, A, Zoccoli, A, Ackers, M, Brock, I, Cammin, J, Cristinziani, M, Desch, K K, Dietsche, W, Eyring, A, Fischer, P, Fleischmann, S, Geich-Gimbel, C, Grosse-Knetter, J, Honerbach, W, Huegging, F, Karagounis, M, Klute, M, Kokott, T, Lehmacher, M, Loddenkoetter, T, Martinez, G, Mathes, M, Meuser, S, Nderitu, S K, Nunes Hanninger, G, Ockenfels, W, Odenthal, I, Peric, I, Pleier, M A, Prabhu, R, Raith, B, Runolfsson, O, Ruwiedel, C, Schmitz, M, Stockmanns, T, Ta, D, Treis, J, Wermes, N, Wienemann, P, Zendler, C, Ahlen, S P, Butler, J M, Hazen, E, Lewandowska, M, Love, J, Marin, A, Nation, N R, Posch, C, Shank, J T, Whitaker, S P, Yan, Z, Youssef, S P, Bensinger, J R, Blocker, C, Dushkin, A, Hashemi, K, Kirsch, L E, Kotchetkov, D, Schricker, A, Skvorodnev, N, Wellenstein, H, Bednar, P, Bruncko, D, Coss, J, Ferencei, J, Gazo, E, Kladiva, E, Lovas, L, Seman, M, Stavina, P, Strizenec, P, Sykora, I, Tokar, S, Tomasz, F, Zenis, T, Zilka, B, Adams, D L, Armstrong, S R, Assamagan, K, Burns, R, Chan, A, Chen, H, Cunha, A, Damazio, D, Deng, W, Duffin, S, Farrell, J, Gibbard, B, Gordeev, A, Gordon, H, Greenwood, D, Hackenburg, R, Hoffmann, A E, Hover, J, Ito, H, Izen, J M, Junnarkar, S S, Kandasamy, A, Kandasamy, S, Kierstead, J A, Klimentov, A, Lanni, F, Le Vine, M, Lissauer, A, Lou, X, Lynn, D, Ma, H, Maeno, T, Makowiecki, D, Misawa, S, Muller, T R, Nevski, P, Paige, F, Panitkin, S, Park, W, Pate, D, Petti, R, Polychronakos, V, Popescu, R, Purohit, M, Radeka, V, Rahm, D, Rajagopalan, S, Redlinger, G R, Rehak, M, Rescia, S, Sexton, K A, Smith, J, Snyder, S, Sondericker, J, Stumer, I, Takai, H, Tarrade, F, Tcherniatine, V, Undrus, A, Wenaus, T, White, S, Wlodek, T, Yarradoddi, K, Yu, D, Zhao, X, Alexa, C, Badescu, E, Boldea, V, Caprini, I, Caprini, M, Caramarcu, C, Chesneanu, D, Ciubancan, M, Constantinescu, S, Dita, P, Dita, S, Gruse, C, Micu, L, Niculescu, M, Pantea, D, Preda, T, Rotaru, M, Gonzalez Silva, M L, Piegaia, R, Romeo, G, Bieri, M, Komaragiri, J R, O'Neil, D C, Rezaie, E, Schouten, D, Stewart, T D, Vetterli, M C, Benedict, B H, Bold, T, Ciobotaru, M D, Corso-Radu, A, Gough Eschrich, I, Hawkins, D, Kolos, S, Lankford, A J, McCormick, C, Mommsen, R, Murillo Garcia, R, Negri, A, Pier, S, Schernau, M, Stancu, S N, Unel, G, Wheeler-Ellis, S J, Chouridou, S, Dorfan, D E, Dubbs, T, Fadeyev, V, Grillo, A A, Hansl-Kozanecka, T, Litke, A M, Lockman, W S, Nielsen, J, Pequenao, J, Rosenbaum, F, Sadrozinski, H F W, Seiden, A, Spencer, E, Taylor, G, Batley, J R, Brochu, F M, Carter, J R, Frost, J A, Goodrick, M J, Hill, J C, Lester, C G, Munday, D J, Palmer, M J, Parker, M A, Phillips, A W, Robinson, D, Ward, C P, White, M J, Aleksa, M, Amaral, P, Amaral, S P, Amelung, C, Anghinolfi, F, Avolio, G, Bachy, G, Baltasar Dos Santos Pedrosa, F, Baron, S, Poy, A Barriuso>, Batraneanu, S, Battistin, M, Beltramello, O, Berge, D, Bergsma, F, Bertinelli, F, Bitadze, A, Blanchot, G, Bock, R, Bogaerts, J A, Boisvert, V, Bonneau, P, Boosten, M, Bosteels, M, Boyd, J, Braem, A, Bremer, J, Bujor, F, Burckhart, H, Burckhart-Chromek, D, Butin, F, Campana, S, Capeans Garrido, M D M, Cardiel Sas, L, Carli, T, Catinaccio, A, Cattai, A, Cernoch, C, Cerri, A, Chevalley, J L, Cook, J, Cornelissen, T, Da Silva, R, Danielsson, H O, Dannheim, D, Dauvergne, J P, De Oliveira Branco, M, Dell'Acqua, A, Delmastro, M, Delruelle, N, Di Girolamo, B, Di Simone, A, Dittus, F, Dobinson, R, Dobos, D, Dobson, M, Donega, M, Drakoulakos, D, Drevermann, H, Dudarev, A, Dydak, F, Eklund, L M, Ellis, N, Elsing, M, Fabjan, C W, Fabre, C, Farthouat, P, Fassnacht, P, Fedorko, I, Ferrari, P, Flammer, J, Flegel, W, Fonseca Martin, T M, Foussat, A, Francis, D, Franz, S, Fratianni, S, Froidevaux, D, Gallas, M V, Garonne, V G, Gayde, J C, Gianotti, F, Gildemeister, O, Godlewski, J, Gollub, N P, Gonidec, A, Goossens, L, Gorini, B, Gorski, B T, Goulette, M, Grabowska-Bold, I, Grognuz, J, Grothe, M E M, Gruwe, M, Gschwendtner, E M, Haas, S, Hahn, F, Haider, S, Hallgren, B, Hatch, M, Haug, F, Hauschild, M, Hauviller, C, Hawkings, R J, Henriques Correia, A M, Hervas, L, Hocker, Andreas>, Hoffmann, H F, Hooton, I, Hryn'ova, T, Hulsbergen, W, Iengo, P, Inigo-Golfin, J, Jaekel, M, Jarp, S, Jarron, P, Jenni, P, Jones, R, Jonsson, O, Joos, M, Joram, C, Kaplon, J, Kataoka, M, Klioutchnikova, T, Knezo, E, Knobloch, J, Koffas, T, Kono, T, Krasznahorkay, A, Kruger, K, Kubischta, W, Lasseur, C, Le Bihan, A C, Leahu, L, Leahu, M, Lee, H, Lehmann Miotto, G, Letheren, M, Lichard, P, Liko, D, Lucas, S, Lytken, E, Mair, K, Mandl, M, Mapelli, A, Mapelli, L, Marchesotti, M, Martin, B, Maugain, J M, McLaren, R A, Meinhard, H, Meirosu, C, Menot, C, Meyer, T C, Michelotto, M, Miele, P, Mladenov, D, Molina-Perez, J, Mornacchi, G, Nairz, A M, Nassiakou, M, Nessi, M, Nicquevert, B, Niinikoski, T, Nordberg, M, Nunes, R, Nyman, T, Onea, A, Pailler, P M, Palestini, S, Palla, J, Papadopoulos, I, Parkman, C, Passardi, G, Passmore, M S, Pauly, T, Pengo, R, Perez Reale, V, Pernegger, H, Petersen, J, Petersen, T C, Pezzetti, M, Pimenta Dos Santos, M A, Pirotte, O, Placci, A, Pommes, K, Poppleton, A, Pospichal, P, Poulard, G, Price, M J, Primor, D, Rabbers, J J, Rammer, H, Rangod, S, Raymond, M, Rembser, C, Roe, S, Rohrbach, F, Ruggiero, G, Sbrissa, E, Schaller, M, Schlager, G, Schlenker, S, Schmid, P, Schmitt, C, Schoerner, T, Schuh, S, Schuler, G, Schweiger, D, Schwick, C, Siebel, M, Sloper, J, Speckmayer, P, Spegel, M, Spigo, G, Spiwoks, R, Sprachmann, G, Stavrianakou, M, Stelzer, H J, Szeless, B, Taboada Gameiro, S, Tappern, G P, Ten Kate, H, Tique Aires Viegas, F J, Treichel, M, Tremblet, L, Tyrvainen, H, Unal, G, Van der Bij, H, Vandelli, W, Vandoni, G, Varela Rodriguez, F, Veness, R, Verducci, M, Vincke, H, von Boehn-Buchholz, R, Voss, R, Vuillemin, V, Vuillermet, R, Wallny, R S, Weilhammer, P M, Wells, P S, Wenig, S, Werner, P, Wiesmann, M, Wildauer, A, Wilkens, H G, Witzeling, W, Wotschack, J, Zajacova, Z, Zema, P F, Zsenei, A, Anderson, K J, Brubaker, E, Costin, T, Feng, E J, Gardner, R W, Gupta, A, Hurwitz, M, Jen-La Plante, I, Kapliy, A, Mambelli, M, Merritt, F S, Oreglia, M J, Pilcher, J E, Shochet, M J, Smirnov, Y, Usai, G, Yorita, K, Apsimon, R, Baines, J T, Barclay, P, Barnett, B M, Batchelor, L E, Baynham, D E, Bizzell, J P, Botterill, D, Brawn, I P, Butterworth, J, Carr, F S, Clifft, R W, Cragg, D A, Dallison, S J, Densham, C J, Emeliyanov, D, Fisher, S M, Gallop, B J, Gee, C N P, Gibson, M D, Gillman, A R, Greenfield, D, Hart, J C, Hatley, R W, Hayler, T, Haywood, S J, Hicheur, A, Holt, R, Holtom, E, Jones, A, Kirk, J, Li, W, Lintern, A J, Macwaters, C, Matheson, J, McCubbin, N A, McMahon, S J, Middleton, R, Morrissey, M C, Murray, W J, Nelson, C, Nichols, A, Norton, P R, Perera, V J O, Phillips, P W, Prieur, D, Qian, W, Rochford, J H, Sankey, D P C, Scott, W G, Shah, T P, Smith, B, Sole, D, Tarrant, J, Towndrow, E F, Tricoli, A, Tyndel, M, Villani, E G, Warner, G P, Weber, M, Wickens, F J, Wielers, M, Wilmut, I, Busato, E, Calvet, D, Cogneras, E, Defay, P O, Febbraro, R, Garde, V, Gris, P L Y, Guicheney, C J, Montarou, G, Pallin, D, Podlyski, F, Santoni, C, Says, L P, Vazeille, F, Bertelsen, H, Czyczula, Z, Dam, M, Driouichi, C, Facius, K, Hansen, F H, Hansen, J R, Hansen, J B, Hansen, J D, Hansen, P H, Klinkby, E B, Lindahl, A, Lundquist, J, Mackeprang, R, Nilsson, B S, Rensch, B, Waananen, A, Xella-Hansen, S, Adorisio, C, Castrovillari, F, Crosetti, G, La Rotonda, L, Lamanna, E, Meoni, E, Policicchio, A, Salvatore, D, Schioppa, M, Susinno, G, Klaiber-Lodewigs, J, Klingenberg, R, Krasel, O, Kudlaty, J, Mass, M, Rajek, S, Reisinger, I, Walbersloh, J, Weber, J, Weingarten, J, Wunstorf, R, Kobel, M, Lacker, H, Ludwig, A, Mader, W F, Schaarschmidt, J, Schumacher, J, Schwierz, R, Warsinsky, M, Aleksandrov, I N, Barashkou, A, Bardin, D Y, Batusov, V, Bednyakov, V A, Boyko, I R, Budagov, I A, Chelkov, G A, Chepurnov, V F, Dedovich, D V, Demichev, M, Evtoukhovitch, P, Glonti, G L, Gongadze, A, Gostkin, M I, Gousakov, I, Grigalashvili, N, Ilyushenka, Y, Kakurin, S, Kalinovskaya, L V, Kazarinov, M Y, Kekelidze, G D, Kharchenko, D, Khovanskiy, N, Khramov, E, Kolesnikov, V, Kotov, V M, Kruchonak, U, Krumshteyn, Z V, Kukhtin, V, Ladygin, E, Lazarev, A B, Liabline, M, 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Konig, S, Duren, M, Mattig, S, Monig, K, Fohlisch, F, Ruhr, F, Dur, H, Akesson, T P A, Mjornmark, J U, Soderberg, M, Kopke, L, Schafer, U, Muller, M, Gottfert, T, Hartel, R, Mohrdieck-Mock, S, Schmucker, H, Strohmer, R, Konig, A C, Rohne, O, Asman, B, Engstrom, M, Sjolin, J, Imhauser, M, Mattig, P
    Publicado 2008
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  19. 8859
  20. 8860
    “…Secondary endpoints were ASDASesr, ASAS20, and ASAS40 response rates and the proportion of patients achieving ASDAS inactive disease and low disease activity at weeks 8 and 16. …”
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    Online Artículo Texto
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